Esophageal manometry in systemic amyloidosis
Abstract
The motility of the esophagus was studied by esophageal manometry in 24 patients with primary amyloidosis and six with secondary amyloidosis. Resting lower esophageal sphincter pressure was decreased in 12 patients with primary amyloidosis and two with secondary amyloidosis; 12 of these 14 patients complained of heartburn. Abnormalities in the motility of the body of the esophagus were found in nine patients with primary amyloidosis and one with secondary amyloidosis. No abnormality of the upper esophageal sphincter was demonstrated in any of the 30 patients. Six of the nine patients with primary amyloidosis exhibiting the most marked esophageal motor dysfunction had striking evidence of peripheral and/or autonomic nervous system involvement. No consistent pattern of motility disorder was observed in either group. The manometric abnormalities observed are consistent with a random deposition of amyloid in the esophagus involving a myopathic and/or neuropathic component.
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Later stages of amyloidosis may show low-amplitude contractions reflecting myopathic infiltration of smooth muscle.
“Manometric studies suggest that early disease can manifest with motor incoordination consistent with neural involvement, whereas later stages may show low-amplitude contractions reflecting myopathic infiltration of smooth muscle (Battle et al., 1979; Camilleri et al., 1985; Rubinow et al., 1983).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Rubinow et al., 1983
Manometric studies suggest that early amyloidosis can manifest with motor incoordination consistent with neural involvement.
“Manometric studies suggest that early disease can manifest with motor incoordination consistent with neural involvement, whereas later stages may show low-amplitude contractions reflecting myopathic infiltration of smooth muscle (Battle et al., 1979; Camilleri et al., 1985; Rubinow et al., 1983).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Rubinow et al., 1983
Cites
Neuropathology of the oesophagus in diabetes mellitus
Smith, B. (1974) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.37.10.1151 · Cited by 80 · see citing works
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Gastrointestinal motility disorders in neurologic disease
Camilleri, M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143771 · Cited by 211 · see citing works
Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction
Shouman, K., Camilleri, M., & Singer, W. (2026) · Autonomic Neuroscience · doi:10.1016/j.autneu.2026.103474
- Authors
- Rubinow, A., Burakoff, R., Cohen, A. S., & Harris, L. D.
- Corresponding author
- Rubinow, Alan
- ORCID
- Cohen, Alan S.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1983-12
- Volume
- 75
- Issue
- 6
- Pages
- 951-956
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W1522987328
- Cited by
- 58
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- esophageal motility, AL amyloidosis, AA amyloidosis, lower esophageal sphincter pressure, heartburn, autonomic nervous system involvement, peripheral nerve involvement, esophageal manometry, amyloid deposition
- MeSH terms
- Adult, Aged, Amyloidosis, Esophagogastric Junction, Esophagus, Female, Humans, Male, Manometry, Middle Aged, Peristalsis
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