Cited by 80Dysphagia Assessment and ManagementGastrointestinal motility and disordersPeripheral Neuropathies and Disorders

Neuropathology of the oesophagus in diabetes mellitus

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Smith, B.·1974·Journal of Neurology, Neurosurgery & Psychiatry

Abstract

Abnormalities of the innervation of the oesophagus have been shown in 18 out of 20 unselected diabetics without clinical dysphagia or neuropathy. The changes appear to be in the axons of the extrinsic and intrinsic parasympathetic fibres. It is probable that, as in the peripheral nerves, the major changes are in the Schwann cells, although here the affected fibres are unmyelinated.

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Registry

Crossref · 10.1136/jnnp.37.10.1151

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  • Sustained hyperglycemia represents the principal driver of DGP pathogenesis; however, disease duration, chronic glycemic variability, and acute hyperglycemia episodes also contribute independently to neural and motor dysfunction, resulting in impaired motility and delayed gastric emptying.

    “Sustained hyperglycemia represents the principal driver; however, disease duration, chronic glycemic variability, and acute hyperglycemia episodes also contribute independently to neural and motor disfunction, resulting in impaired motility and delayed gastric emptying [27–31].”

    From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [30]

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  • Damage to extrinsic vagal efferent pathways and intrinsic enteric nerves results in alteration of impulse transmission with loss of gastric tone, reduced contractility and impaired coordination of peristaltic waves, slowing gastric emptying.

    “Damage to these pathways results in alteration of impulse tramission [28] with loss of gastric tone, reduced contractility and impaired coordination of peristaltic waves, slowing gastric emptying [25, 29, 30].”

    From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [30]

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Research works printed but not linked: 2

  1. Mandelstam, P., and Lieber, A. (1967). Esophageal dys- function in diabetic neuropathy-gastroenteropathy. Journal of the American Medical Association, 201, 582-586.
  2. Thomas, P. K. (1967). Diabetic neuropathy: morphological aspects. Proceedings of the Royal Society of Medicine, 60, 145.

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Authors
Smith, B.
Affiliations
St Bartholomew's Hospital (GB)
Corresponding author
Smith, B.
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
1974-10-01
Volume
37
Issue
10
Pages
1151-1154
ISSN
0022-3050 (ISSN-L)
OpenAlex
W2042452865
Cited by
80
References
16
Citations by year
2026: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 2
FWCI
6.44
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
diabetes mellitus, dysphagia, Schwann cells, unmyelinated nerve fibers, peripheral nerve pathology
MeSH terms
Diabetes Mellitus, Diabetic Neuropathies, Esophagus, Humans, Hypoglycemic Agents, Insulin, Myenteric Plexus, Sympathetic Nervous System, Vagus Nerve, Wallerian Degeneration

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