Lack of response to suramin in patients with AIDS and AIDS-related complex
Abstract
Forty-one homosexual men with the acquired immune deficiency syndrome (AIDS) or AIDS-related complex were treated with 0.5, 1.0, or 1.5 g of suramin weekly for up to six months. In no patient was evidence of symptomatic improvement or regression of Kaposi's sarcoma shown. Opportunistic infections developed in 16 patients during therapy. Only six patients (15 percent) became human immunodeficiency virus (HIV) culture-negative during treatment, despite documentation of adequate serum suramin levels. All but one of these six have had disease progression. Decreases in the numbers of total T4 cells with time were observed in both AIDS and AIDS-related complex subgroups. Toxicity was significant and consisted of fatigue, fever, and hepatic and renal dysfunction, all of which were observed most frequently with the 1.0 or 1.5 g dosages. Fatal hepatic failure developed in two patients, and adrenal insufficiency was documented in eight patients. Suramin is a toxic agent that shows no virologic, immunologic, or clinical benefit in patients with HIV-related disease.
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Suramin had been found to induce adrenal insufficiency in humans and to have adrenolytic activity in animal experiments, where it led to inflammatory changes of the adrenal cortex.
“Suramin, a compound used traditionally for the treatment of sleeping sickness, had been found to induce adrenal insufficiency in humans and to have adrenolytic activity in animal experiments, where it led to inflammatory changes of the adrenal cortex (310, 311).”
From Adrenocortical carcinoma (2014) · cites this paper as [311]
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- Authors
- Kaplan, L. D., Wolfe, P. R., Volberding, P. A., Feorino, P., Abrams, D. I., Levy, J. A., Wong, R., Kaufman, L., & Gottlieb, M. S.
- Corresponding author
- Kaplan, Lawrence D.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1987-03
- Volume
- 82
- Issue
- 3
- Pages
- 615-620
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W1995671386
- Cited by
- 60
- References
- 22
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 1
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- suramin, AIDS, AIDS-related complex, Kaposi's sarcoma, HIV infection, drug toxicity, opportunistic infections, T4 lymphocyte count, liver failure, adrenal insufficiency, treatment response, gay men
- MeSH terms
- Acquired Immunodeficiency Syndrome, Adult, AIDS-Related Complex, Clinical Trials as Topic, Drug Administration Schedule, HIV, Humans, Male, Suramin, T-Lymphocytes, Virus Replication
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