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Cited by 396Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 47 of the 49 references it cites were found in a registry or an index.

Neurogenic orthostatic hypotension: A double-blind, placebo-controlled study with midodrine

Jankovic, Joseph, Gilden, Janice L., Hiner, Bradley C., Kaufmann, Horacio, Brown, David C., Coghlan, Cecil H., Rubin, Michael, Fouad-Tarazi, Fetnat M.·1993·The American Journal of Medicine
DOI 10.1016/0002-9343(93)90230-m
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Abstract

Purpose To investigate the efficacy and safety of midodrine for treatment of patients with orthostatic hypotension due to autonomic failure.Patients Ninety-seven patients with orthostatic hypotension were randomized in a 4-week, double-blinded, placebo-controlled study with a 1-week placebo run-in period. Patients ranged in age from 22 to 86 years (mean: 61 years).Methods After a 1-week run-in phase, either placebo or midodrine at a dose of 2.5 mg, 5 mg, or 10 mg was administered three times a day for 4 weeks. Both the placebo group and the 2.5-mg midodrine group received constant doses throughout the double-blind phase. The patients receiving 5 mg or 10 mg of midodrine were given doses that were increased at weekly intervals by 2.5-mg increments until the designated dose was reached. Efficacy evaluations were based on an improvement at 1-hour postdose in standing systolic blood pressure and in symptoms of orthostatic hypotension (syncope, dizziness/lightheadedness, weakness/fatigue, and low energy level).Results Midodrine (10 mg) increased standing systolic blood pressure by 22 mm Hg (28%, p < 0.001 versus placebo). Midodrine improved (p < 0.05) the following symptoms of orthostatic hypotension compared to placebo: dizziness/lightheadedness, weakness/fatigue, syncope, low energy level, impaired ability to stand, and feelings of depression. The overall side effects were mainly mild to moderate. One or more side effects were reported by 22% of the placebo group compared with 27% of the midodrine-treated group. Scalp pruritus/tingling, which was reported by 10 of 74 (13.5%) of the midodrine-treated patients, was most frequent. Other reported side effects included supine hypertension (8%) and feelings of urinary urgency (4%).Conclusion We conclude that midodrine is an effective and well-tolerated treatment for moderate-to-severe orthostatic hypotension associated with autonomic failure.

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Citations

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Research works printed but not linked: 10

  1. Polinsky, 1981, Effect of indomethacin inhibition of prostaglandin synthesis on blood pressure and plasma norepinephrine levels in patients with orthostatic hypotension, Neurology, 31, 63
  2. Lachner, 1974, Pharmakologie von midodrin sowie dessen klinsche austestung bei hypotoner regulationsstorung des kreislaufes, Wien Klin Wochenschr, 86, 344
  3. Kratz, 1978, Klinische vergleichsstudie einer antihypotensiven therapie mit Gutron® and einem depot-praparat, DR. Med Mabuse, 7, 36
  4. Kuehner, 1990, Standing up to orthostatic hypotension, Can J Diagnosis, 81
  5. Bankhead, 1990, Finding the cause [of] syncope, Medical World News, 28
  6. Petersen-Clonan, 1986, A compassionate use study of midodrine in the treatment of patients with orthostatic hypotension, J Clin Pharmacol, 26, 543
  7. Vukovich, 1989, Correction of severe orthostatic hypotension by midodrine, a new alpha adrenoceptor agonist, Clin Pharmacol Ther, 45, 123
  8. Ehringer, 1971, Untersuchungen der peripheren hamodynamik des menschen nach intravenoser infusion einer kleinen dosis von dl-(2′-5′-dimethyloxyphenyl)-2-glycinamidoathanol-(1)-hydrochlorid (=ST 1085), Internationale Zeitschrift fuer Klinische Pharmakologie, Therapie, and Toxicologie, 4, 415
  9. Hitzenberger, 1973, Hamodynamische wirkungen einer neuen blutdrucksteigernden substanz (2′,5′-dimethoxyphenyl- 2-glycinami-doathonal-1-hydrochlorid) nach intravenoser verabreichung, Int J Clin Pharmacol Res, 7, 323
  10. 1987, 1, 197

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Metadata

Authors
Jankovic, J., Gilden, J. L., Hiner, B. C., Kaufmann, H., Brown, D. C., Coghlan, C. H., Rubin, M., & Fouad-Tarazi, F. M.
Affiliations
  • Baylor College of Medicine (US)
  • Marshfield Clinic (US)
  • Mount Sinai Health System (US)
  • Abbott Northwestern Hospital (US)
  • University of Alabama at Birmingham (US)
  • Cornell University (US)
  • Cleveland Clinic (US)
Corresponding author
Jankovic, Joseph
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
1993-07
Volume
95
Issue
1
Pages
38-48
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/0002-9343(93)90230-m
OpenAlex
W2029445782
Cited by
396
References
49
Citations by year
2026: 8 · 2025: 17 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 17 · 2019: 9 · 2018: 9 · 2017: 24 · 2016: 14 · 2015: 17 · 2014: 24 · 2013: 18 · 2012: 8
FWCI
4.51
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
neurogenic orthostatic hypotension, midodrine, autonomic failure, syncope, dizziness, drug safety and efficacy, adverse effects, supine hypertension, urinary urgency
MeSH terms
Adult, Aged, Aged, 80 and over, Autonomic Nervous System Diseases, Double-Blind Method, Female, Humans, Hypotension, Orthostatic, Male, Middle Aged, Midodrine

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