A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension
Abstract
OBJECTIVE: To determine the best therapeutic strategy for the use of midodrine in patients with neurogenic orthostatic hypotension (NOH). BACKGROUND: Midodrine is a peripherally acting alpha-adrenergic agonist useful in the treatment of NOH. However, neither the most effective dosage of midodrine nor the required frequency of administration is established. DESIGN/METHODS: Midodrine dose-blood pressure response, pharmacokinetics, and duration of action were examined in a double-blind, placebo-controlled, four-way crossover trial. Twenty-five patients with NOH were randomized to receive on successive days placebo or midodrine 2.5, 10, or 20 mg. Blood pressures of patients in the supine and standing positions were measured sequentially. A global assessment of the patient's overall symptom improvement after each leg of the study was performed. Blood levels of midodrine and its active metabolite, desglymidodrine, were assayed. RESULTS: Midodrine significantly increased standing systolic blood pressure, with the increase peaking at 1 hour. There was a significant linear relation between midodrine dosage and mean systolic blood pressure. The mean score for global improvement of symptoms was significantly higher for midodrine (10 and 20 mg) compared with placebo. The half-life of desglymidodrine was approximately 4 hours. CONCLUSION: A 10-mg dose of midodrine prescribed two to three times daily is effective in increasing orthostatic blood pressure and ameliorating symptoms in patients with NOH.
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Midodrine increases BP both in the supine and upright posture and ameliorates symptoms of OH.
“There is no doubt that midodrine increases BP both in the supine and upright posture, and ameliorates the symptoms of OH.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [326]
Midodrine was shown to be effective in three randomized placebo-controlled trials.
“Midodrine (2.5-10 mg t.i.d) was shown to be effective in three randomized placebo-controlled trials. 324-326”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [326]
Cites
Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine
Jankovic, J., Gilden, J. L., Hiner, B. C., Kaufmann, H., Brown, D. C., Coghlan, C. H., Rubin, M., & Fouad-Tarazi, F. M. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90230-m · Cited by 396 · see citing works
Self-citationMcTavish, D., & Goa, K. L. (1989) · Drugs · doi:10.2165/00003495-198938050-00004 · Cited by 160 · see citing works
Kaufmann, H., Brannan, T. S., Krakoff, L. R., Yahr, M. D., & Mandeli, J. (1988) · Neurology · doi:10.1212/wnl.38.6.951 · Cited by 136 · see citing works
Self-citationPharmacodynamics of midodrine, an antihypotensive agent
Zachariah, P. K., Bloedow, D. C., Moyer, T. P., Sheps, S. G., SCHIRGER, A., & Fealey, R. D. (1986) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1986.101 · Cited by 57 · see citing works
[The bioavailability of midodrin and alpha-2,5-dimethoxyphenyl-beta-aminoethanol hydrochloride].
Grobecker, H., Kees, F., Linden, M., Schrader, E., & Welte, S. (1987) · PubMed · Cited by 10 · see citing works
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Developed in collaboration with, European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), societies, E. B. T. F., European Society of Emergency Medicine (EuSEM), European Federation of Internal Medicine (EFIM), European Union Geriatric Medicine Society (EUGMS), American Geriatrics Society (AGS), European Neurological Society (ENS), et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp298 · Cited by 2,040 · see citing works
Self-citation2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951 · see citing works
Pharmacological Treatment of Parkinson Disease
Connolly, B. S., & Lang, A. E. (2014) · JAMA · doi:10.1001/jama.2014.3654 · Cited by 1,510 · see citing works
K/DOQI Clinical Practice Guidelines for Cardiovascular Disease in Dialysis Patients
(2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.01.019 · Cited by 1,433 · see citing works
Fanciulli, A., & Wenning, G. K. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1311488 · Cited by 827 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 484 · see citing works
2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya‐Mitjans, À., de Lange, F. J., Deharo, J., Elliot, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martiın, A., et al. (2018) · Kardiologia Polska · doi:10.5603/kp.2018.0161 · Cited by 474 · see citing works
Wenning, G. K., Colosimo, C., Geser, F., & Poewe, W. H. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00662-8 · Cited by 467 · see citing works
Gibbons, C. H., Schmidt, P., Biaggioni, I., Frazier-Mills, C., Freeman, R., Isaacson, S., Karabin, B., Kuritzky, L., Lew, M., Low, P., et al. (2017) · Journal of Neurology · doi:10.1007/s00415-016-8375-x · Cited by 455 · see citing works
Self-citationShen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000499 · Cited by 453 · see citing works
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000498 · Cited by 408 · see citing works
Neurogenic Orthostatic Hypotension
Freeman, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp074189 · Cited by 384 · see citing works
EFNS guidelines on the diagnosis and management of orthostatic hypotension
Lahrmann, H., Cortelli, P., Hilz, M., Mathias, C. J., Struhal, W., & Tassinari, M. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01512.x · Cited by 334 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.003 · Cited by 327 · see citing works
Poewe, W. H., Stanković, I., Halliday, G. M., Meissner, W. G., Wenning, G. K., Pellecchia, M. T., Seppi, K., Palma, J., & Kaufmann, H. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00382-6 · Cited by 287 · see citing works
Self-citationFreeman, R. L., Abuzinadah, A. R., Gibbons, C. H., Jones, P. K., Miglis, M. G., & Sinn, D.-I. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.079 · Cited by 286 · see citing works
Droxidopa for neurogenic orthostatic hypotension
Kaufmann, H., Freeman, R. L., Biaggioni, I., Low, P. A., Pedder, S. C. J., Hewitt, L. A., Mauney, J., Feirtag, M., & Mathias, C. J. (2014) · Neurology · doi:10.1212/wnl.0000000000000615 · Cited by 279 · see citing works
Self-citationGuía de práctica clínica para el diagnóstico y manejo del síncope (versión 2009)
Moya‐Mitjans, À., Sutton, R., Ammirati, F., Blanc, J., Brignole, M., Dahm, J. B., Deharo, J., Gajek, J. J., Gjesdal, K., Krahn, A. D., et al. (2009) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(09)73541-8 · Cited by 277 · see citing works
Practice Parameter: Treatment of nonmotor symptoms of Parkinson disease [RETIRED]
Zesiewicz, T., Sullivan, K. L., Arnulf, I., Chaudhuri, К. R., Morgan, J. C., Gronseth, G., Miyasaki, J. M., Iverson, D. J., & Weiner, W. J. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d55f24 · Cited by 273 · see citing works
Kaufmann, H., Norcliffe‐Kaufmann, L., & Palma, J. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1509723 · Cited by 271 · see citing works
Self-citationPyridostigmine Treatment Trial in Neurogenic Orthostatic Hypotension
Singer, W., Sandroni, P., Opfer‐Gehrking, T. L., Suárez, G. A., Klein, C. M., Hines, S. M., O’Brien, P. C., Slezak, J. M., & Low, P. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.4.noc50340 · Cited by 268 · see citing works
Self-citationTreatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
Palma, J., & Kaufmann, H. (2018) · Movement Disorders · doi:10.1002/mds.27344 · Cited by 246 · see citing works
Self-citationThe Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale
Kaufmann, H., Malamut, R. I., Norcliffe‐Kaufmann, L., Rosa, K., & Freeman, R. L. (2011) · Clinical Autonomic Research · doi:10.1007/s10286-011-0146-2 · Cited by 245 · see citing works
Self-citationGender affects sympathetic and hemodynamic response to postural stress
Shoemaker, J. K., Hogeman, C. S., Khan, M. R., Kimmerly, D. S., & Sinoway, L. I. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.5.h2028 · Cited by 243 · see citing works
Diagnosis and treatment of orthostatic hypotension
Wieling, W., Kaufmann, H., Claydon, V. E., van Wijnen, V. K., Harms, M. P. M., Juraschek, S. P., & Thijs, R. D. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00169-7 · Cited by 227 · see citing works
Self-citationManagement of neurogenic orthostatic hypotension: an update
Low, P. A., & Singer, W. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70088-7 · Cited by 224 · see citing works
Self-citationSinger, W. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.9.1294 · Cited by 196 · see citing works
Management of Parkinson's disease: An evidence-based review
Lang, A. E., & Lees, A. J. (2002) · Movement Disorders · doi:10.1002/mds.5554 · Cited by 184 · see citing works
Fragile X-Associated Tremor/Ataxia Syndrome: Clinical Phenotype, Diagnosis, and Treatment
Leehey, M. A. (2009) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3181af59c4 · Cited by 178 · see citing works
A Systematic Review of the Management of Orthostatic Hypotension After Spinal Cord Injury
Krassioukov, A. V., Eng, J. J., Warburton, D. E. R., & Teasell, R. W. (2009) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2009.01.009 · Cited by 175 · see citing works
Drug-Related Orthostatic Hypotension: Beyond Anti-Hypertensive Medications
Rivasi, G., Rafanelli, M., Mossello, E., Brignole, M., & Ungar, A. (2020) · Drugs & Aging · doi:10.1007/s40266-020-00796-5 · Cited by 186 · see citing works
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.002 · Cited by 155 · see citing works
Evaluation and management of orthostatic hypotension.
Lanier, J. B., Mote, M. B., & Clay, E. C. (2011) · PubMed · Cited by 152 · see citing works
Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management
Metzler, M., Duerr, S., Granata, R., Krismer, F., Robertson, D., & Wenning, G. K. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6736-7 · Cited by 139 · see citing works
Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review
Izcovich, A., González Malla, C., Manzotti, M., Catalano, H. N., & Guyatt, G. (2014) · Neurology · doi:10.1212/wnl.0000000000000815 · Cited by 131 · see citing works
Ramirez, C. E., Okamoto, L. E., Arnold, A. C., Gamboa, A. C., Diedrich, A., Choi, L., Raj, S. R., Robertson, D., Biaggioni, I., & Shibao, C. A. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04225 · Cited by 121 · see citing works
Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem
Fedorowski, A., Ricci, F., Hamrefors, V., Sandau, K. E., Chung, T., Muldowney, J. A. S., Gopinathannair, R., & Olshansky, B. (2022) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.121.010573 · Cited by 120 · see citing works
Invited Article: Autonomic ganglia
Vernino, S. A., Sandroni, P., Singer, W., & Low, P. A. (2008) · Neurology · doi:10.1212/01.wnl.0000312280.44805.5d · Cited by 116 · see citing works
Self-citationShibao, C. A., Okamoto, L. E., Gamboa, A. C., Yu, C., Diedrich, A., Raj, S. R., Robertson, D., & Biaggioni, I. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.154898 · Cited by 112 · see citing works
Orthostatic Hypotension in Parkinson Disease
Palma, J., & Kaufmann, H. (2019) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.09.002 · Cited by 109 · see citing works
Self-citationChéhensse, C., Bahrami, S., Denys, P., Clément, P., Bernabé, J., & Giuliano, F. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt029 · Cited by 107 · see citing works
Orthostatic hypotension: A review
Joseph, A., Wanono, R., Flamant, M., & Vidal‐Petiot, E. (2017) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2017.01.003 · Cited by 109 · see citing works
Management of Orthostatic Hypotension in Parkinson’s Disease
Fanciulli, A., Leys, F., Falup‐Pecurariu, C., Thijs, R. D., & Wenning, G. K. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-202036 · Cited by 108 · see citing works
Autonomic dysfunction in Parkinson disease
Kaufmann, H., & Goldstein, D. S. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53491-0.00021-3 · Cited by 105 · see citing works
Self-citationPhillips, A. A., Warburton, D. E. R., Ainslie, P. N., & Krassioukov, A. V. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.3 · Cited by 103 · see citing works
Cachexia and asthenia in cancer patients
Bruera, E. D., & Sweeney, C. (2000) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00033-4 · Cited by 103 · see citing works
Droxidopa in neurogenic orthostatic hypotension
Kaufmann, H., Norcliffe‐Kaufmann, L., & Palma, J. (2015) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2015.1057504 · Cited by 102 · see citing works
Self-citationEvidence-based treatment of neurogenic orthostatic hypotension and related symptoms
Eschlböck, S., Wenning, G. K., & Fanciulli, A. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1791-y · Cited by 102 · see citing works
Nonpharmacological treatment of reflex syncope
Wieling, W., Colman, N., Krediet, C. T. P., & Freeman, R. (2004) · Clinical Autonomic Research · doi:10.1007/s10286-004-1009-x · Cited by 102 · see citing works
Charkoudian, N., Martin, E. A., Dinenno, F. A., Eisenach, J. H., Dietz, N. M., & Joyner, M. J. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00265.2004 · Cited by 100 · see citing works
Wenning, G. K., & Braune, S. (2001) · CNS Drugs · doi:10.2165/00023210-200115110-00003 · Cited by 102 · see citing works
Orthostatic hypotension in older people: considerations, diagnosis and management
Dani, M., Dirksen, A., Taraborrelli, P., Panagopolous, D., Torocastro, M., Sutton, R., & Lim, P. B. (2021) · Clinical Medicine · doi:10.7861/clinmed.2020-1044 · Cited by 97 · see citing works
Hauser, R. A., Hewitt, L. A., & Isaacson, S. (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-130259 · Cited by 97 · see citing works
Efficacy of treatments for orthostatic hypotension: a systematic review
Logan, I., & Witham, M. D. (2012) · Age and Ageing · doi:10.1093/ageing/afs061 · Cited by 93 · see citing works
Epidemiology, Diagnosis, and Management of Neurogenic Orthostatic Hypotension
Palma, J., & Kaufmann, H. (2017) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12478 · Cited by 90 · see citing works
Self-citationSaklani, P., Krahn, A. D., & Klein, G. J. (2013) · Circulation · doi:10.1161/circulationaha.112.138396 · Cited by 89 · see citing works
Management of Orthostatic Hypotension
Palma, J., & Kaufmann, H. (2020) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000816 · Cited by 90 · see citing works
Self-citationJuraschek, S. P., Cortez, M. M., Flack, J. M., Ghazi, L., Kenny, R. A., Rahman, M., Spikes, T. A., Shibao, C. A., & Biaggioni, I. (2024) · Hypertension · doi:10.1161/hyp.0000000000000236 · Cited by 80 · see citing works
Raj, S. R., & Coffin, S. T. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2012.11.004 · Cited by 79 · see citing works
Autonomic nervous system dysfunction in Parkinson’s disease
Zesiewicz, T. A., Baker, M. J., Wahba, M. N., & Hauser, R. A. (2003) · Current Treatment Options in Neurology · doi:10.1007/s11940-003-0005-0 · Cited by 78 · see citing works
Midodrine for Orthostatic Hypotension: A Systematic Review and Meta-Analysis of Clinical Trials
Parsaik, A. K., Singh, B., Altayar, O., Mascarenhas, S. S., Singh, S. K., Erwin, P. J., & Murad, M. H. (2013) · Journal of General Internal Medicine · doi:10.1007/s11606-013-2520-3 · Cited by 73 · see citing works
Phillips, A. A., Krassioukov, A. V., Ainslie, P. N., & Warburton, D. E. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01090.2013 · Cited by 72 · see citing works
Current treatments in familial dysautonomia
Palma, J., Norcliffe‐Kaufmann, L., Fuente‐Mora, C., Percival, L., Mendoza‐Santiesteban, C. E., & Kaufmann, H. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.970530 · Cited by 71 · see citing works
Self-citationGordon, V. M., Opfer-Gehrking, T. L., Novak, V., & Low, P. A. (2000) · Clinical Autonomic Research · doi:10.1007/bf02291387 · Cited by 69 · see citing works
Self-citationPrajjwal, P., Sanga, H. S. F., Acharya, K., Tango, T., John, J., Rodriguez, R. S. C., Marsool, M. D. M., Sulaimanov, M., Ahmed, A., & Hussin, O. A. (2023) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000001142 · Cited by 70 · see citing works
Traon, A. P., Amarenco, G., Duerr, S., Kaufmann, H., Lahrmann, H., Shaftman, S. R., Tison, F., Wenning, G. K., Goetz, C. G., Poewe, W. H., et al. (2011) · Movement Disorders · doi:10.1002/mds.23742 · Cited by 68 · see citing works
Self-citationDuschek, S., Hadjamu, M., & Schandry, R. (2006) · Psychophysiology · doi:10.1111/j.1469-8986.2006.00472.x · Cited by 68 · see citing works
Smith, W. B., Wan, H., Much, D. R., Robinson, A., & Martin, P. T. (2016) · Clinical Autonomic Research · doi:10.1007/s10286-016-0363-9 · Cited by 67 · see citing works
Treatment of dysautonomia associated with Parkinson's disease
Mostile, G., & Jankovic, J. J. (2009) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(09)70820-x · Cited by 66 · see citing works
LeWitt, P. A., Kymes, S., & Hauser, R. A. (2020) · Aging and Disease · doi:10.14336/ad.2019.0805 · Cited by 64 · see citing works
Levine, A. R., Meyer, M. J., Bittner, E. A., Berg, S. M., Kalman, R., Stanislaus, A. B., Ryan, C., Ball, S. A., & Eikermann, M. (2013) · Journal of Critical Care · doi:10.1016/j.jcrc.2013.05.021 · Cited by 64 · see citing works
Traon, A. P., Piedvache, A., Perez‐Lloret, S., Buonaura, G. C., Cock, V. C. D., Colosimo, C., Cortelli, P., Debs, R., Duerr, S., Fanciulli, A., et al. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309999 · Cited by 64 · see citing works
Orthostatic hypotension: managing a difficult problem
Jones, P. K., Shaw, B. H., & Raj, S. R. (2015) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2015.1095090 · Cited by 61 · see citing works
Multiple system atrophy: current and future approaches to management
Flabeau, O., Meissner, W. G., & Tison, F. (2010) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285610375328 · Cited by 61 · see citing works
Voortman, M., Fritz, D., Vogels, O. J. M., Eftimov, F., van de Beek, D., Brouwer, M. C., & Drent, M. (2017) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000413 · Cited by 61 · see citing works
Midodrine for the weaning of vasopressor infusions
Poveromo, L. B., Michalets, E. L., & Sutherland, S. E. (2016) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12375 · Cited by 57 · see citing works
Pharmacotherapy of autonomic failure
Shibao, C. A., Okamoto, L. E., & Biaggioni, I. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.05.009 · Cited by 56 · see citing works
Palma, J., González‐Duarte, A., & Kaufmann, H. (2019) · Clinical Autonomic Research · doi:10.1007/s10286-019-00623-x · Cited by 56 · see citing works
Self-citationMeta-analysis of the safety and efficacy of droxidopa for neurogenic orthostatic hypotension
Elgebaly, A. S., Abdelazeim, B., Mattar, O. M., Gadelkarim, M., Salah, R., & Negida, A. (2016) · Clinical Autonomic Research · doi:10.1007/s10286-016-0349-7 · Cited by 51 · see citing works
Tchen, S., & Sullivan, J. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.02.011 · Cited by 50 · see citing works
Current pharmacologic treatment for orthostatic hypotension
Freeman, R. L. (2008) · Clinical Autonomic Research · doi:10.1007/s10286-007-1003-1 · Cited by 50 · see citing works
Efficacy of single or combined midodrine and pyridostigmine in orthostatic hypotension
Byun, J., Moon, J., Kim, D.-Y., Shin, H., Sunwoo, J., Lim, J., Kim, T., Lee, W. J., Lee, H. S., Jun, J., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004340 · Cited by 50 · see citing works
Pharmacologic treatment of orthostatic hypotension
Park, J., Okamoto, L. E., Shibao, C. A., & Biaggioni, I. (2020) · Autonomic Neuroscience · doi:10.1016/j.autneu.2020.102721 · Cited by 50 · see citing works
Syncope: Diagnosis and Management
Walsh, K., Hoffmayer, K. S., & Hamdan, M. H. (2014) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2014.11.001 · Cited by 49 · see citing works
The Treatment of Primary Orthostatic Hypotension
Hale, G. M., Valdes, J., & Brenner, M. J. (2017) · Annals of Pharmacotherapy · doi:10.1177/1060028016689264 · Cited by 49 · see citing works
Midodrine prevents orthostatic intolerance associated with simulated spaceflight
Ramsdell, C. D., Mullen, T. J., Sundby, G. H., Rostoft, S., Sheynberg, N., Aljuri, N., Maa, M. T., Mukkamala, R., Sherman, D., Toska, K., et al. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2245 · Cited by 49 · see citing works
Increased Central Arterial Stiffness Explains Baroreflex Dysfunction in Spinal Cord Injury
Phillips, A. A., Krassioukov, A. V., Ainslie, P. N., Coté, A. T., & Warburton, D. E. R. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3280 · Cited by 48 · see citing works
Garland, E. M., Hooper, W. B., & Robertson, D. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53491-0.00020-1 · Cited by 47 · see citing works
Charnogursky, G. A., Lee, H. X., & Lopez, N. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-7020-4087-0.00051-6 · Cited by 47 · see citing works
Jans, Ø., Mehlsen, J., Kjærsgaard‐Andersen, P., Husted, H., Solgaard, S., Josiassen, J., Lunn, T. H., & Kehlet, H. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000890 · Cited by 45 · see citing works
Lamarre-Cliché, M., du Souich, P., de Champlain, J., & Larochelle, P. M. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.09.001 · Cited by 45 · see citing works
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Cutsforth‐Gregory, J. K., & Low, P. A. (2019) · Neurology and Therapy · doi:10.1007/s40120-019-00152-9 · Cited by 45 · see citing works
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Wenning, G. K., Geser, F., & Poewe, W. H. (2005) · Movement Disorders · doi:10.1002/mds.20543 · Cited by 45 · see citing works
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Cruz, D. N. (2000) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.1.4.835 · Cited by 44 · see citing works
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Diamond, A. L., & Jankovic, J. J. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.8.1181 · Cited by 43 · see citing works
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Lee, J. G., Joo, K. W., Chung, W. K., Jung, Y., Zheung, S. H., Yoon, H., Kim, Y. S., Ahn, C., Han, J. S., Kim, S., et al. (2001) · PubMed · Cited by 41 · see citing works
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Ong, A. C. L., Myint, P. K., Shepstone, L., & Potter, J. F. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12122 · Cited by 41 · see citing works
Isaacson, S., & Skettini, J. (2014) · Vascular Health and Risk Management · doi:10.2147/vhrm.s53983 · Cited by 40 · see citing works
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Self-citation
- Authors
- Wright, R. A., Kaufmann, H. C., Perera, R., Opfer-Gehrking, T. L., McElligott, M. A., Sheng, K. N., & Low, P. A.
- Affiliations
- Mayo Clinic (US)
- Venue
- Neurology
- Published
- 1998-07
- Volume
- 51
- Issue
- 1
- Pages
- 120-124
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2048764982
- Cited by
- 331
- References
- 5
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 14 · 2020: 23 · 2019: 8 · 2018: 16 · 2017: 24 · 2016: 9 · 2015: 16 · 2014: 24 · 2013: 22 · 2012: 5
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Foundation for Medical Education and Research
- National Institutes of Health (1p01ns032352-01a1)
- National Institute of Neurological Disorders and Stroke (P01 NS 32352)
- National Center for Research Resources (5MO RR00071)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- midodrine, neurogenic orthostatic hypotension, alpha-adrenergic agonists, dose-response relationship, pharmacokinetics, blood pressure, symptom improvement
- MeSH terms
- Adrenergic alpha-Agonists, Adult, Aged, Autonomic Nervous System Diseases, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Hypotension, Orthostatic, Male, Middle Aged, Midodrine, Cross-Over Studies
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