The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Qualitative assessment of maternal uterine and fetal umbilical artery blood flow and resistance in laboring patients by Doppler velocimetry
Abstract
The purpose of this study is to evaluate the effect of uterine contractions during labor on both the uterine and the umbilical circulations. Twenty-seven patients in active labor were studied by continuous-wave Doppler velocimetry. Umbilical, left uterine, and right uterine arterial waveforms were obtained before, during, and after peak uterine contractions, and the ratio of maximum systolic and minimum diastolic velocities was calculated. Fifteen patients showed absent flow in end diastole on the uterine artery waveform and had significantly higher intra-amniotic pressures (64.5 +/- 3.5 mm Hg) during the peak amplitude of the uterine contraction compared with the 12 patients with maintained end diastolic flow (46.5 +/- 2.6 mm Hg; p less than 0.05). During the peak amplitude of the uterine contractions the 12 patients maintaining end-diastolic flow had significantly higher systolic/diastolic ratios in the uterine artery (6.5 +/- 1.5) compared with either before or after a contraction (2.1 +/- 0.15 and 2.0 +/- 0.2, respectively; p less than 0.05). Also, these 12 patients showed a linear relationship between the systolic/diastolic ratio and the intrauterine pressure. However, no differences were observed in the umbilical artery systolic/diastolic ratios before, during, or after a contraction in the intensity range studied. On the contrary, during contractions an increase in uterine artery resistance occurs with decreased or absent end-diastolic flow, which bears an inverse linear relationship to the intensity of the contraction. This suggests that during uterine contractions the human fetus continues to have uninterrupted fetoplacental blood flow, whereas the degree of interruption or reduction in uteroplacental blood flow is dependent on the intensity of uterine contraction.
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“At 35 mm Hg of intrauterine pressure, which is the level at which we can usually feel the contractions on the abdominal wall, the uteroplacental blood flow disappears at the end of diastole, and at 60 mm Hg diastolic flow ceases completely.”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [13]
Citations
Cites
Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation
GILES, W. B., TRUDINGER, B. J., & BAIRD, P. J. (1985) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01045.x · Cited by 724
(2020) · Questions from NeoReviews · doi:10.1542/9781610023993-2-ch27 · Cited by 480
Uterine artery Doppler velocimetry in pregnant women with hypertension
Fleischer, A., Schulman, H., Farmakides, G., Bracero, L., Grunfeld, L., Rochelson, B., & Koenigsberg, M. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90462-x · Cited by 283
MAKOWSKI, E. L., MESCHIA, G., DROEGEMUELLER, W., & BATTAGLIA, F. C. (1968) · Circulation Research · doi:10.1161/01.res.23.5.623 · Cited by 221
Umbilical velocity wave ratios in human pregnancy
Schulman, H., Fleischer, A., Stern, W., Farmakides, G., Jagani, N., & Blattner, P. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(84)90541-6 · Cited by 214
Fetal umbilical venous flow measured in utero by pulsed Doppler and B-mode ultrasound
Gill, R. W., Trudinger, B. J., Garrett, W. J., Kossoff, G., & Warren, P. S. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90495-6 · Cited by 163
Smith, J. F. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000350 · Cited by 138
Uterine and umbilical artery velocimetry during normal labor
Fleischer, A., Anyaegbunam, A. A., Schulman, H., Farmakides, G., & Randolph, G. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80342-3 · Cited by 103
Quantitative measurement of fetal blood flow using Doppler ultrasound.
Erskine, R. L. A., & Ritchie, J. W. K. (1985) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01398.x · Cited by 82
Theoretical analysis of factors affecting placental O 2 transfer
Longo, L., Hill, E., & Power, G. (1972) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1972.222.3.730 · Cited by 65
Cited by
Oxidative Stress, Gene Expression, and Protein Changes Induced in the Human Placenta during Labor
Cindrova-Davies, T., Yung, H.-W., Johns, J., Spasic-Boskovic, O., Korolchuk, S., Jauniaux, E., Burton, G. J., & Charnock-Jones, D. S. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070528 · Cited by 297
Optimising sample collection for placental research
Burton, G. J., Sebire, N. J., Myatt, L., Tannetta, D., Wang, Y.-L., Sadovsky, Y., Staff, A. C., & Redman, C. W. (2014) · Placenta · doi:10.1016/j.placenta.2013.11.005 · Cited by 263
Calcium signaling and uterine contractility
Wray, S. (2003) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(03)00089-3 · Cited by 204
PLA2G6 guards placental trophoblasts against ferroptotic injury
Beharier, O., Tyurin, V. A., Goff, J. P., Guerrero-Santoro, J., Kajiwara, K., Chu, T., Tyurina, Y. Y., St Croix, C. M., Wallace, C. T., Parry, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009201117 · Cited by 198
The physiology of intrapartum fetal compromise at term
Turner, J. M., Mitchell, M. D., & Kumar, S. S. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.07.032 · Cited by 194
Metadata
- Authors
- Brar, H. S., Platt, L. D., DeVore, G. R., Horenstein, J., & Medearis, A. L.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Brar, Harbinder S.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1988-04
- Volume
- 158
- Issue
- 4
- Pages
- 952-956
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2013857648
- Cited by
- 119
- References
- 14
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- uterine artery blood flow, umbilical artery blood flow, uterine contraction, labor, uteroplacental circulation, fetoplacental circulation, uterine artery resistance, end-diastolic flow, Doppler velocimetry
- MeSH terms
- Adult, Blood Circulation, Female, Humans, Infant, Newborn, Labor, Obstetric, Pregnancy, Rheology, Umbilical Arteries, Uterine Contraction, Uterus, Vascular Resistance
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- CoChat. (2026). Citation check: Qualitative assessment of maternal uterine and fetal umbilical artery blood flow and resistance in laboring patients by Doppler velocimetry. https://app.cochat.ai/papers/10.1016/0002-9378(88)90100-7
- The paper
- Brar, H. S., Platt, L. D., DeVore, G. R., Horenstein, J., & Medearis, A. L. (1988). Qualitative assessment of maternal uterine and fetal umbilical artery blood flow and resistance in laboring patients by Doppler velocimetry. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/0002-9378(88)90100-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
