The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites
Abstract
Progesterone and its metabolites were measured in serum extracts by radioimmunoassay and gas chromatography-mass spectrometry, respectively, after ingestion of micronized progesterone by eight postmenopausal women. One subject received 400 mg of micronized progesterone orally that induced a hypnotic state that lasted for approximately 2 hours. Blood samples were drawn periodically from all subjects for measurement of progesterone and its metabolites in serum. Levels of serum progesterone and its metabolites increased significantly from baseline values and reached a peak between 2 and 6 hours after oral progesterone administration. Significant quantities of five compounds (progesterone, 5 alpha-pregnan-3 alpha-ol-20-one, 5 beta-pregnan-3 alpha-ol-20-one, 5 beta-pregnan-3 alpha,20 beta-diol, and 5 beta-pregnan-3 alpha-ol-11,20-dione) that have been reported to possess anesthetic qualities were identified. The sedative and hypnotic effects of oral administration of progesterone may be mediated through those compounds.
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“Progesterone produces its anxiolytic/hypnotic effects via allopregnanolone's binding to GABAA-receptors [96, 97]”
From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [96]
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Cites
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., & Paul, S. M. (1986) · Science · doi:10.1126/science.2422758 · Cited by 2,225
Harrison, N. L., Majewska, M., Harrington, J. W., & Barker, J. L. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-5347(25)00332-5 · Cited by 611
CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS1
Selye, H. (1942) · Endocrinology · doi:10.1210/endo-30-3-437 · Cited by 350
PROGESTERONE AND MAINTENANCE OF PREGNANCY: IS PROGESTERONE NATURE'S IMMUNOSUPPRESSANT?*
Siiteri, P. K., Febres, F., Clemens, L. E., Chang, R. J., Gondos, B., & Stites, D. P. (1977) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1977.tb29431.x · Cited by 346
Bardin, C. W., Milgröm, E., & MAUVAIS-JARVIS, P. (1983) · Raven Press eBooks · Cited by 197
Progesterone and the premenstrual syndrome: a double blind crossover trial.
Dennerstein, L., Spencer-Gardner, C., Gotts, G. H., Brown, J. B., Smith, M., & Burrows, G. D. (1985) · BMJ · doi:10.1136/bmj.290.6482.1617 · Cited by 192
Plasma levels of progesterone after vaginal, rectal, or intramuscular administration of progesterone
Nillius, S. J., & Johansson, E. D. B. (1971) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(71)90686-7 · Cited by 151
Percutaneous absorption of steroids
MAUVAIS-JARVIS, P., Vickers, C. F. H., & Wepierre, J. (1980) · Medical Entomology and Zoology · Cited by 137
Jensen, J., Riis, B. J., Strøm, V., Nilas, L., & Christiansen, C. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(87)90204-3 · Cited by 134
Bioavailability of oral micronized progesterone
Maxson, W. S., & Hargrove, J. T. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48977-6 · Cited by 122
Self-citationAdvances in epileptology: the XVth epilepsy international symposium
Hughes, J. R. (1985) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(85)90013-6 · Cited by 112
Absorption and metabolism of oral progesterone.
Whitehead, M. I., Townsend, P. T., Gill, D., Collins, W. P., & Campbell, S. C. (1980) · BMJ · doi:10.1136/bmj.280.6217.825 · Cited by 111
Steroids. CCCX. Structure-activity relation of some steroidal hypnotic agents
Gyermek, L., Iriarte, J., & Crabbé, P. (1968) · Journal of Medicinal Chemistry · doi:10.1021/jm00307a026 · Cited by 101
Lignieres, B. D., & Vincens, M. (1982) · Maturitas · doi:10.1016/0378-5122(82)90021-4 · Cited by 83
Physiological aspects of steroids with anaesthetic properties.
HOLZBAUER, M. (1976) · PubMed · Cited by 78
Ovum donation—a simplified approach
Serhal, P. F., & Craft, I. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59354-6 · Cited by 65
Ottosson, U. B. (1984) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348409157016 · Cited by 51
Induction of Anesthesia, Seizures and Sleep by Steroid Hormones
HEUSER, G. (1967) · Anesthesiology · doi:10.1097/00000542-196701000-00018 · Cited by 37
Högskilde, S., NIELSEN, J. W., Carl, P., & Sørensen, M. B. (1987) · Anaesthesia · doi:10.1111/j.1365-2044.1987.tb03080.x · Cited by 33
The Use of Progesterone in the Treatment of PMS
Maxson, W. S. (1987) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-198706000-00026 · Cited by 24
Self-citationENZYME INHIBITION BY STEROID ANAESTHETIC AGENTS DERIVED FROM PROGESTERONE
Banks, P. A., & PEACE, C. B. (1985) · British Journal of Anaesthesia · doi:10.1093/bja/57.5.512 · Cited by 10
Isolation of progesterone-forty years ago
Butenandt, A., & Westphal, U. (1974) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(74)90193-8 · Cited by 10
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Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives
Rupprecht, R., & Holsboer, F. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01399-5 · Cited by 640
Maternity blues and major endocrine changes: Cardiff puerperal mood and hormone study II
Harris, B. L., Lovett, L. M., Newcombe, R. G., Read, G. F., Walker, R., & Riad-Fahmy, D. (1994) · BMJ · doi:10.1136/bmj.308.6934.949 · Cited by 486
Miles, R. A., Paulson, R. J., Løbo, R. A., Press, M. F., Dahmoush, L., & Sauer, M. V. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56935-0 · Cited by 392
Hormonal Treatment of Postmenopausal Women
Wood, A. J. J., & Belchetz, P. E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301508 · Cited by 386
Metadata
- Authors
- Arafat, E. S., Hargrove, J. T., Maxson, W. S., Desiderio, D. M., Wentz, A. C., & Andersen, R. N.
- Affiliations
- Rust College (US)
- Vanderbilt University Medical Center (US)
- University of Tennessee Health Science Center (US)
- Corresponding author
- Hargrove, Joel T.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1988-11
- Volume
- 159
- Issue
- 5
- Pages
- 1203-1209
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2042977357
- Cited by
- 134
- References
- 22
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 2 · 2015: 1 · 2013: 4 · 2012: 2
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2s14rr002866-04)
- National Institute of General Medical Sciences (GM26666)
- National Center for Research Resources (5S14RR02866)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- micronized progesterone, sedative effects, hypnotic effects, progesterone metabolites, postmenopausal women, oral administration, serum progesterone, 5alpha-pregnan-3alpha-ol-20-one, sleep induction
- MeSH terms
- Administration, Oral, Blood Chemical Analysis, Chromatography, Gas, Dose-Response Relationship, Drug, Female, Humans, Hypnotics and Sedatives, Middle Aged, Powders, Progesterone, Mass Spectrometry, Time Factors
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