The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Evidence for estrogen synthesis in adenomyotic tissues
Abstract
Objective To investigate steroidogenesis in eutopic and ectopic endometrial tissues in adenomyosis.Study design Aromatase and estrone sulfatase activities were determined by anion-exchange resin column chromatography, thin-layer chromatography, and cocrystallization. The effects of danazol on the activity of these enzymes were also examined. Moreover, localization of aromatase in eutopic and ectopic endometrial tissues was immunohistochemically examined with antihuman placental aromatase cytochrome P-450 antibody.Results Aromatase and estrone sulfatase activities were detected in ectopic endometrium. The activity of these enzymes was significantly suppressed by danazol. In addition, aromatase was immunohistochemically detected in glandular cells of eutopic and ectopic endometrial tissues.Conclusions The results suggest that estrogen is synthesized in the eutopic and ectopic endometrial tissues of women with uterine adenomyosis and that it may affect the growth of adenomyosis. Danazol suppressed synthesis of estrogen in vitro.
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In the citing paper
“Our results of activated estrogen signaling as well as reduced ERα expression in OE and AD lesions are consistent with overwhelming data showing the same (Yamamoto et al., 1993; Brandenberger et al., 1999; Fujimoto et al., 1999; Attar et al., 2009; Mehasseb et al., 2011; Heublein et al., 2012; Samartzis et al., 2012).”
From Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium (2025) · cites this paper as Yamamoto et al., 1993
In the citing paper
“In addition, genes involved in estrogen biosynthesis, such as steroidogenic acute regulatory protein (StAR) and P450 aromatase, are upregulated in adenomyosis [48,49].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [49]
In the citing paper
“Moreoever, increased local production of estrogen is common to all subtypes of endometriosis83 and even to adenomyosis84.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [84]
In the citing paper
“The expression of the P450 aromatase is increased in adenomyotic tissue and in the ectopic and eutopic endometrium of women with endometriosis [35–41].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [35]
Citations
Cites
Danazol Inhibits Steroidogenesis
Barbieri, R. L., Canick, J. A., Makris, A., Todd, R. B., DAVIES, I. J., & Ryan, K. J. (1977) · Fertility and Sterility · doi:10.1016/s0015-0282(16)42732-9 · Cited by 124
Steroid Receptor Levels and Histology of Endometriosis and Adenomyosis
Tamaya, T., Motoyama, T., Ohono, Y., Ide, N., Tsurusaki, T., & Okada, H. (1979) · Fertility and Sterility · doi:10.1016/s0015-0282(16)43935-x · Cited by 118
Self-citationESTROGEN SYNTHESIS IN NORMAL AND MALIGNANT HUMAN ENDOMETRIUM
Tseng, L., Mazella, J., Mann, W. J., & Chumas, J. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-5-1029 · Cited by 103
An Enzyme-Linked Immunosorbent Assay for Quantitation of Aromatase Cytochrome P-450*
Kitawaki, J., Yoshida, N., & Osawa, Y. (1989) · Endocrinology · doi:10.1210/endo-124-3-1417 · Cited by 82
Self-citation(1989) · PubMed · Cited by 77
CULLEN, T. S. (1908) · JAMA · doi:10.1001/jama.1908.25310280023002d · Cited by 71
Tseng, L., Mazella, J., & Sun, B. (1986) · Endocrinology · doi:10.1210/endo-118-4-1312 · Cited by 63
Aromatization of androstenedione by normal and neoplastic endometrium of the uterus
Junko, Y., Yamamoto, T., & Hiroji, O. (1985) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(85)90142-6 · Cited by 54
Self-citationEstrogen biosynthesis in human uterine adenomyosis
Urabe, M., Yamamoto, T., Kitawaki, J., Honjo, H., & Okada, H. (1989) · European Journal of Endocrinology · doi:10.1530/acta.0.1210259 · Cited by 52
Self-citationInhibition of Adrenal Steroidogenesis by Danazol in Vivo
Stillman, R. J., Fencl, M. D., Schiff, I., Barbieri, R. L., & Tulchinsky, D. (1980) · Fertility and Sterility · doi:10.1016/s0015-0282(16)44657-1 · Cited by 38
Cited by
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Pathophysiology of adenomyosis
Ferenczy, A. S. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.4.312 · Cited by 512
The pathophysiology of endometriosis and adenomyosis, tissue injury and repair
Leyendecker, G., Wildt, L., & Mall, G. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1191-0 · Cited by 418
Endometriosis: The pathophysiology as an estrogen-dependent disease
Kitawaki, J., Kado, N., Ishihara, H., Koshiba, H., Kitaoka, Y., & Honjo, H. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00260-1 · Cited by 370
Self-citationKitawaki, J., Noguchi, T., Amatsu, T., Maeda, K., Tsukamoto, K., Yamamoto, T., Fushiki, S., Osawa, Y., & Honjo, H. (1997) · Biology of Reproduction · doi:10.1095/biolreprod57.3.514 · Cited by 305
Self-citationVinatier, D., Orazi, G., Cosson, M., & Dufour, P. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00405-x · Cited by 299
Metadata
- Authors
- Yamamoto, T., Noguchi, T., Tamura, T., Kitawaki, J., & Okada, H.
- Affiliations
- Kyoto Prefectural University of Medicine (JP)
- Corresponding author
- Yamamoto, Takara
- ORCID
- Kitawaki, Jo
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 169
- Issue
- 3
- Pages
- 734-738
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2028723332
- Cited by
- 111
- References
- 16
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- adenomyosis, estrogen synthesis, steroidogenesis, aromatase, estrone sulfatase, ectopic endometrium, eutopic endometrium, danazol, endometrial glandular cells
- MeSH terms
- Adult, Aromatase, Chromatography, Ion Exchange, Danazol, Dose-Response Relationship, Drug, Endometriosis, Estrogens, Female, Humans, Middle Aged, Myometrium, Neoplasms, Hormone-Dependent, Sulfatases, Uterine Neoplasms, Gene Expression Regulation, Enzymologic, Aromatase Inhibitors
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