Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium

Nie, Jichan; Yi, Yunhua; Liu, Xishi; Guo, Sun-Wei

doi:10.1093/hropen/hoaf028

Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium

STUDY QUESTION Do all ectopic endometrial lesions (endometriosis and adenomyosis) universally have activated estrogen signaling? SUMMARY ANSWER Estrogen signaling diminishes concordantly with increased fibrosis in ectopic endometrium, with deep endometriotic (DE) lesions exhibiting an estrogen bi…