The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, α-tocopherol, and beta-carotene in women with preeclampsia
Abstract
Objective Our purpose was to investigate the plasma levels of three potent antioxidant nutrients in women with preeclampsia. Study design Fasting venous blood samples were collected from 30 women with preeclampsia and from 44 women with uncomplicated pregnancies. The criteria for recruitment included age 15 to 35 years, gestational age 28 to 42 weeks, singleton pregnancy, intact membranes, absence of labor contractions, and absence of any other medical complication concurrent with preeclampsia. Reduced ascorbic acid, alpha-tocopherol, and beta-carotene levels were assayed with high-pressure liquid chromatography. Results Plasma levels of reduced ascorbic acid were significantly decreased in patients with mild and severe preeclampsia (p Conclusion In patients with preeclampsia antioxidant nutrients may be utilized to a greater extent to counteract free radical-mediated cell disturbances, resulting in a reduction in antioxidant plasma levels. Water-soluble antioxidant nutrients may initially be consumed, followed by lipid-soluble antioxidants.
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“In patients with preeclampsia, antioxidant nutrient levels as well as antioxidant response was lower while lipid peroxidation was higher (Takagi et al, 2004;Aydin et al, 2004 andMikhail et al, 1994).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Mikhail et al, 1994
Citations
Cites
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870
Preeclampsia: an endothelial cell disorder
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Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols
Mascio, P. D., Murphy, M., & Sies, H. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.194s · Cited by 776
Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans.
Kayden, H. J., & Traber, M. G. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40727-8 · Cited by 584
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Lipid peroxidation in pregnancy: New perspectives on preeclampsia
Hubel, C. A., Roberts, J. M., Taylor, R. N., Musci, T. J., Rogers, G. M., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90778-3 · Cited by 445
Wefers, H., & Sies, H. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14105.x · Cited by 389
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Antioxidant nutrients and disease prevention: an overview
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Research works printed but not linked: 1
- American College of Obstetricians and Gynecologists. Management of Preeclampsia. Washington, DC: American College of Obstetricians and Gynecologists, 1986. (Technical bulletin no 91).
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Role of oxidative stress in female reproduction
Agarwal, A., Gupta, S., & Sharma, R. K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-28 · Cited by 1,729
Chappell, L. C., Seed, P. T., Briley, A. L., Kelly, F. J., Lee, R., Hunt, B. J., Parmar, K., Bewley, S., Shennan, A. H., Steer, P. J., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)80010-5 · Cited by 784
Etiology and pathogenesis of preeclampsia: Current concepts
Dekker, G., & Sibai, B. M. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70160-7 · Cited by 760
Jauniaux, E. R. M., Poston, L., & Burton, G. J. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml016 · Cited by 613
Vitamins C and E and the Risks of Preeclampsia and Perinatal Complications
Rumbold, A. R., Crowther, C. A., Haslam, R. R., Dekker, G., & Robinson, J. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054186 · Cited by 466
Metadata
- Authors
- Mikhail, M. S., Anyaegbunam, A., Garfinkel, D., Palan, P. R., Basu, J., & Romney, S. L.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Mikhail, Magdy S.
- ORCID
- Basu, Jayasri
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 171
- Issue
- 1
- Pages
- 150-157
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2063095299
- Cited by
- 229
- References
- 29
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 5
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
- Keywords
- preeclampsia, antioxidant nutrients, reduced ascorbic acid, vitamin C, alpha-tocopherol, vitamin E, beta-carotene, free radicals, oxidative stress, pregnancy complications
- MeSH terms
- Adolescent, Adult, Ascorbic Acid, Carotenoids, Female, Humans, Pilot Projects, Pre-Eclampsia, Pregnancy, Vitamin E, Case-Control Studies, beta Carotene
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