The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, α-tocopherol, and beta-carotene in women with preeclampsia
Abstract
Objective Our purpose was to investigate the plasma levels of three potent antioxidant nutrients in women with preeclampsia. Study design Fasting venous blood samples were collected from 30 women with preeclampsia and from 44 women with uncomplicated pregnancies. The criteria for recruitment included age 15 to 35 years, gestational age 28 to 42 weeks, singleton pregnancy, intact membranes, absence of labor contractions, and absence of any other medical complication concurrent with preeclampsia. Reduced ascorbic acid, alpha-tocopherol, and beta-carotene levels were assayed with high-pressure liquid chromatography. Results Plasma levels of reduced ascorbic acid were significantly decreased in patients with mild and severe preeclampsia (p Conclusion In patients with preeclampsia antioxidant nutrients may be utilized to a greater extent to counteract free radical-mediated cell disturbances, resulting in a reduction in antioxidant plasma levels. Water-soluble antioxidant nutrients may initially be consumed, followed by lipid-soluble antioxidants.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In patients with preeclampsia, antioxidant nutrient levels as well as antioxidant response was lower while lipid peroxidation was higher (Takagi et al, 2004;Aydin et al, 2004 andMikhail et al, 1994).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Mikhail et al, 1994
Citations
Cites
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870
Preeclampsia: an endothelial cell disorder
Roberts, J. M., Taylor, R. N., Musci, T. J., Rodgers, G. M., Hubel, C. A., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90665-0 · Cited by 1,859
Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols
Mascio, P. D., Murphy, M., & Sies, H. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.194s · Cited by 776
Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans.
Kayden, H. J., & Traber, M. G. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40727-8 · Cited by 584
yw, A. L., Michalak, J., Stępień, A., & Kadziołka, A. (1986) · Clinica Chimica Acta · doi:10.1016/0009-8981(86)90247-0 · Cited by 520
Lipid peroxidation in pregnancy: New perspectives on preeclampsia
Hubel, C. A., Roberts, J. M., Taylor, R. N., Musci, T. J., Rogers, G. M., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90778-3 · Cited by 445
Wefers, H., & Sies, H. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14105.x · Cited by 389
Roberts, J. M., Taylor, R. N., & Goldfien, A. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.8.700 · Cited by 389
Halliwell, B. B. (1989) · PubMed Central · Cited by 366
Antioxidant nutrients and disease prevention: an overview
Diplock, A. T. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.189sb · Cited by 337
Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells
Rodgers, G. M., Taylor, R. N., & Roberts, J. M. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(88)80169-8 · Cited by 278
Wang, Y., Walsh, S. W., Guo, J., & Zhang, J. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90017-l · Cited by 256
FREE RADICAL BIOLOGY: XENOBIOTICS, CANCER, AND AGING*
Pryor, W. A. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb31228.x · Cited by 249
Desforges, J. F., Cunningham, F. G., & Lindheimer, M. D. (1992) · New England Journal of Medicine · doi:10.1056/nejm199204023261405 · Cited by 230
Antioxidant systems in normal pregnancy and in pregnancy-induced hypertension
Wisdom, S., Wilson, R., McKillop, J. H., & Walker, J. J. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90018-m · Cited by 228
MATERNAL VASCULAR PROSTACYCLIN ACTIVITY IN PRE-ECLAMPSIA
Bussolino, F., Benedetto, C., Massobrio, M., & Camussi, G. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92746-4 · Cited by 193
Maseki, M., Nishigaki, I., Hagihara, M., Yutaka, T., & Yagi, K. (1981) · Clinica Chimica Acta · doi:10.1016/0009-8981(81)90071-1 · Cited by 190
Membrane damage due to lipid oxidation
Niki, E., Yamamoto, Y., Komuro, E., & Sato, K. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.201s · Cited by 179
Sera antioxidant activity in uncomplicated and preeclamptic pregnancies
Davidge, S. T., Hubel, C. A., Brayden, R. D., Capeless, E. C., & McLaughlin, M. K. (1993) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(93)90421-r · Cited by 163
Plasma levels of antioxidantβ‐carotene and α‐tocopherol in uterine cervix dysplasias and cancer
Palan, P. R., Mikhail, M. S., Basu, J., & Romney, S. L. (1991) · Nutrition and Cancer · doi:10.1080/01635589109514106 · Cited by 150
Self-citationTocopherol Stabilizes Membrane against Phospholipase A, Free Fatty Acids, and Lysophospholipidsa
Kagan, V. E. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb14913.x · Cited by 144
Diabetic Embryopathy Studies With Animal and In Vitro Models
Eriksson, U. J., Borg, L., Forsberg, H., & Styrud, J. (1991) · Diabetes · doi:10.2337/diab.40.2.s94 · Cited by 83
Presence of lipid hydroperoxide in human plasma.
Warso, M. A., & Lands, W. E. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111745 · Cited by 79
Lipid peroxidation in pregnancy: New perspectives on preeclampsia
Hubel, C., Roberts, J., Taylor, R. D., Musci, T., Rogers, G., & McLaughlin, M. K. (1990) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(90)90502-c · Cited by 54
Garzetti, G. G., Tranquilli, A. L., Cugini, A. M., Mazzanti, L., Cester, N., & Romaninï, C. (1993) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(93)90341-s · Cited by 46
Effects of smoking and oral contraception on plasma β-carotene levels in healthy women
Palan, P. R., Romney, S. L., Vermund, S. H., Mikhail, M. G., & Basu, J. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90742-4 · Cited by 31
Self-citationEffects of ascorbic and dehydroascorbic acid on the multiplication of tumor ascites cells in vitro
Liotti, F. S., Menghini, A. R., Guerrieri, P., Talesa, V. N., & Bodo, M. (1984) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf00402472 · Cited by 27
Basu, J., Mikhail, M. S., Payraudeau, P. H., Palan, P. R., & Romney, S. L. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90779-7 · Cited by 23
Self-citationPlasma reduced and total ascorbic acid in healthy women: Effects of smoking and oral contraception
Basu, J., Vermund, S. H., Mikhail, M. S., Palan, P. R., & Romney, S. L. (1989) · Contraception · doi:10.1016/0010-7824(89)90017-6 · Cited by 13
Self-citation
Research works printed but not linked: 1
- American College of Obstetricians and Gynecologists. Management of Preeclampsia. Washington, DC: American College of Obstetricians and Gynecologists, 1986. (Technical bulletin no 91).
Cited by
Sorted by citations
Role of oxidative stress in female reproduction
Agarwal, A., Gupta, S., & Sharma, R. K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-28 · Cited by 1,729
Chappell, L. C., Seed, P. T., Briley, A. L., Kelly, F. J., Lee, R., Hunt, B. J., Parmar, K., Bewley, S., Shennan, A. H., Steer, P. J., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)80010-5 · Cited by 784
Etiology and pathogenesis of preeclampsia: Current concepts
Dekker, G., & Sibai, B. M. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70160-7 · Cited by 760
Jauniaux, E. R. M., Poston, L., & Burton, G. J. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml016 · Cited by 613
Vitamins C and E and the Risks of Preeclampsia and Perinatal Complications
Rumbold, A. R., Crowther, C. A., Haslam, R. R., Dekker, G., & Robinson, J. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054186 · Cited by 466
Metadata
- Authors
- Mikhail, M. S., Anyaegbunam, A., Garfinkel, D., Palan, P. R., Basu, J., & Romney, S. L.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Mikhail, Magdy S.
- ORCID
- Basu, Jayasri
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 171
- Issue
- 1
- Pages
- 150-157
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2063095299
- Cited by
- 229
- References
- 29
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 5
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
- Keywords
- preeclampsia, antioxidant nutrients, reduced ascorbic acid, vitamin C, alpha-tocopherol, vitamin E, beta-carotene, free radicals, oxidative stress, pregnancy complications
- MeSH terms
- Adolescent, Adult, Ascorbic Acid, Carotenoids, Female, Humans, Pilot Projects, Pre-Eclampsia, Pregnancy, Vitamin E, Case-Control Studies, beta Carotene
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review