Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases

Tissue sulfhydryl groups

Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824

The preparation and properties of two new chromogenic substrates of trypsin

Erlanger, B. F., Kokowsky, N., & Cohen, W. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90145-x · Cited by 3,346

Determination of sulfhydryl groups with 2,2′- or 4,4′-dithiodipyridine

Grassetti, D. R., & Murray, J. F. (1967) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(67)90426-2 · Cited by 988

The synthesis and analytical use of a highly sensitive and convenient substrate of elastase

Bieth, J. G., Spiess, B., & Wermuth, C. G. (1974) · Biochemical Medicine · doi:10.1016/0006-2944(74)90134-3 · Cited by 732

Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.

Nakajima, K., Powers, J. C., Ashe, B. M., & Zimmerman, M. D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50690-6 · Cited by 595

New Fluorogenic Substrates for α-Thrombin, Factor Xa, Kallikreins, and Urokinase1

Morita, T., Kato, H., Iwanaga, S., Takada, K., Kimura, T., & Sakakibara, S. (1977) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131840 · Cited by 382

Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substrates

Zimmerman, M. D., Ashe, B. M., Yurewicz, E. C., & Patel, G. F. (1977) · Analytical Biochemistry · doi:10.1016/0003-2697(77)90006-9 · Cited by 264

Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

Powers, J. C., Gupton, B. F., Harley, A. D., Nishino, N., & Whitley, R. J. (1977) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(77)90203-0 · Cited by 223

A new fluorogenic substrate for chymotrypsin

Zimmerman, M., Yurewicz, E. C., & Patel, G. F. (1976) · Analytical Biochemistry · doi:10.1016/s0003-2697(76)80066-8 · Cited by 187

On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1

McDonald, J. K., & Ellis, S. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90137-x · Cited by 165

Proteases from purulent sputum. Purification and properties of the elastase and chymotrypsin-like enzymes.

Twumasi, D. Y., & Liener, I. E. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71845-0 · Cited by 115

Substrate specificity of the elastase and the chymotrypsin-like enzyme of the human granulocyte

Zimmerman, M., & Ashe, B. M. (1977) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(77)90337-0 · Cited by 99

Fluorescence assay of X-prolyl dipeptidyl-aminopeptidase activity with a new fluorogenic substrate

Kato, T., Nagatsu, T., Kimura, T., & Sakakibara, S. (1978) · Biochemical Medicine · doi:10.1016/0006-2944(78)90035-2 · Cited by 93

Active-site specific inhibitors of elastase

Powers, J. C., & Tuhy, P. M. (1973) · Biochemistry · doi:10.1021/bi00747a032 · Cited by 87

The action of elastase on p-nitroanilide substrates

Bieth, J. G., & Wermuth, C. G. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)90673-6 · Cited by 81

Synthesis of a key fluorogenic amide, L-arginine-4-methylcoumaryl-7-amide (L-Arg-MCA) and its derivatives. Fluorescence assays for trypsin and papain.

Kanaoka, Y., TAKAHASHI, T., Nakayama, H., Takada, K., Kimura, T., & Sakakibara, S. (1977) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.25.3126 · Cited by 65

N-acetyl-(L-Ala)3-p-nitroanilide as a new chromogenic substrate for elastase

Feinstein, G., Kupfer, A., & Sokolovsky, M. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)91508-8 · Cited by 62

A new fluorogenic substrate for aminopeptidase.

Kanaoka, Y., TAKAHASHI, T., & Nakayama, H. (1977) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.25.362 · Cited by 57

Mechanisms of pulmonary injury

Turino, G. M., Rodriguez, J. R., Greenbaum, L. M., & Mandl, I. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90142-9 · Cited by 55

Peptide chloromethyl ketones as irreversible inhibitors of elastase

Thompson, R. C., & BLOUT, E. R. (1973) · Biochemistry · doi:10.1021/bi00725a008 · Cited by 54

Fluorescent substrate assay for antithrombin III

Mitchell, G. A., Hudson, P. M., Huseby, R. M., Pochron, S. P., & Gargiulo, R. J. (1978) · Thrombosis Research · doi:10.1016/0049-3848(78)90293-1 · Cited by 48

Inhibition of human leukocyte elastase by peptide chloromethyl ketones

Tuhy, P. M. (1975) · FEBS Letters · doi:10.1016/0014-5793(75)80527-8 · Cited by 47

Use of N-benzoyl-L-tyrosine thiobenzyl ester as a protease substrate. Hydrolysis by alpha-chymotrypsin and subtilisin BPN.

Farmer, D. A., & Hageman, J. H. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40953-8 · Cited by 40

Use of peptidyl-4-methoxy-2-naphthylamides to assay plasmin

Clavin, S. A., Bobbitt, J. L., Shuman, R. T., & Smithwick, E. L. (1977) · Analytical Biochemistry · doi:10.1016/0003-2697(77)90656-x · Cited by 32

Studies on tissue culture plasminogen activator II. The detection and assay of urokinase and plasminogen activator from LLC-PK1 cultures (porcine) by the synthetic substrate Nα-benzyloxycarbonyl-glycyl-glycyl-arginyl-4-methoxy-2-napthylamide

Huseby, R. M., Clavin, S. A., Smith, R. E., HULL, R. N., & Smithwick, E. L. (1977) · Thrombosis Research · doi:10.1016/0049-3848(77)90050-0 · Cited by 26

The Reaction of Active‐Site Inhibitors with Elastase Using a New Assay Substrate

Thomson, A., & Denniss, I. S. (1973) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1973.tb03024.x · Cited by 18

Sensitive fluorescence assays for urokinase using synthetic peptide 4-methoxy-β-naphthylamide substrates

Bigbee, W. L., Weintraub, H. B., & Jensen, R. H. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90403-7 · Cited by 17

Several Derivatives of Acetyl-dl-phenylalanine1

Goldenberg, V., Goldenberg, H., & McLaren, A. (1950) · Journal of the American Chemical Society · doi:10.1021/ja01167a512 · Cited by 13

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

Korkmaz, B., Horwitz, M. S., Jenne, D. E., & Gauthier, F. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002733 · Cited by 898

Replacement Therapy for Alpha1-Antitrypsin Deficiency Associated with Emphysema

Wewers, M. D., Casolaro, M. A., Sellers, S. E., Swayze, S. C., McPhaul, K. M., Wittes, J. T., & Crystal, R. G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704233161704 · Cited by 631

Matrix Metalloproteinase Expression and Production by Alveolar Macrophages in Emphysema

Finlay, G. A., O’Driscoll, L., RUSSELL, K. J., D'ARCY, E. M., Masterson, J., FitzGerald, M. X., & O'CONNOR, C. M. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.1.9612018 · Cited by 437

Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates

Barrett, A. J. (1980) · Biochemical Journal · doi:10.1042/bj1870909 · Cited by 404

IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection

Wu, Q., Martin, R. J., Rino, J. G., Breed, R., Torres, R. M., & Chu, H. W. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.10.012 · Cited by 301

The synthesis and analytical use of a highly sensitive and convenient substrate of elastase

Bieth, J. G., Spiess, B., & Wermuth, C. G. (1974) · Biochemical Medicine · doi:10.1016/0006-2944(74)90134-3 · Cited by 732

Synthesis and Analytical Use of 3-Carboxypropionyl-alanyl-alanyl-valine-4-nitroanilide: A Specific Substrate for Human Leukocyte Elastase

Wenzel, H., Engelbrecht, S., REICH, H., MONDRY, W., & Tschesche, H. (1980) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1980.361.2.1413 · Cited by 39

N-acetyl-(L-Ala)3-p-nitroanilide as a new chromogenic substrate for elastase

Feinstein, G., Kupfer, A., & Sokolovsky, M. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)91508-8 · Cited by 62

An improved spectrophotometric assay for leucine aminopeptidase

Beattie, R., Guthrie, D. J. S., Elmore, D. T., Williams, C. H., & Walker, B. (1987) · Biochemical Journal · doi:10.1042/bj2420281 · Cited by 10

Water-soluble macromolecular fluorogenic substrates for assaying proteinases: Determination of pancreatic elastase activity

Anjuère, F., Monsigny, M. L. P., & Mayer, R. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90436-w · Cited by 8