Nitrogen metabolism in tumor bearing mice
Abstract
In experiments with whole animals infested with a highly malignant strain of Ehrlich ascites tumor cells, serial concentrations of amino acids were determined for host plasma, ascitic fluid, and tumor cells, throughout tumor development. Concentration gradients of glutamine, asparagine, valine, leucine, isoleucine, phenylalanine, tyrosine, histidine, tryptophan, arginine, serine, methionine, and taurine from the host plasma toward the ascitic liquid were established; while on the other hand, concentration gradients from the ascitic liquid toward the plasma were established for glutamate, aspartate, glycine, alanine, proline, and threonine. With the exception of aspartate the concentrations of these amino acids were highest inside the cells. Arginine was the only amino acid not detected in tumor cells. In vitro incubations of tumor cells in the presence of glutamine and/or glucose, as the energy and nitrogen sources, confirmed the amino acid fluxes previously deduced from the observed relative concentrations of amino acids in plasma, ascitic liquid, and tumor cells, suggesting that glutamate, alanine, aspartate, glycine, and serine can be produced by tumors. These findings support that changes in amino acid patterns occurring in the host system are related to tumor development.
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Glutamine is the most rapidly consumed amino acid by Ehrlich ascites carcinomas and several hepatomas and carcinosarcomas proliferating in vivo.
“glutamine was found to be the most rapidly consumed amino acid by Ehrlich ascites carcinomas as well as by a number of hepatomas and carcinosarcomas proliferating in vivo”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Marquez et al., 1989
Numerous tumorigenic contexts are associated with depletion of glutamine from the tumor environment compared to normal tissue.
“numerous tumorigenic contexts are associated with the depletion of glutamine from the tumor environment as compared to the corresponding normal tissue”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Marquez et al., 1989
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Early differential expression of two glutaminase mRNAs in mouse spleen after tumor implantation
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Expression of different mitogen‐regulated protein/proliferin mRNAs in Ehrlich carcinoma cells
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- Authors
- Márquez, J., Sánchez-Jiménez, F., Medina, M. A., Quesada, A. R., & de Castro, I. N.
- Affiliations
- Universidad de Málaga (ES)
- Corresponding author
- Márquez, Javier
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 1989-02
- Volume
- 268
- Issue
- 2
- Pages
- 667-675
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2129150382
- Cited by
- 86
- References
- 35
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 3 · 2013: 2 · 2012: 3
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- Ehrlich ascites carcinoma, plasma amino acids, ascitic fluid, cancer cells, glutamine, glutamate, aspartic acid, alanine, serine, glycine, amino acid flux, carcinogenesis, tumor-host interaction
- MeSH terms
- Amino Acids, Animals, Carcinoma, Ehrlich Tumor, Neoplasm Transplantation, Nitrogen, Time Factors, Mice
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