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Regulation of cholesterol ester synthesis in cultured glial and neuronal cells

Volpe, Joseph J., Hennessy, Sally W., Wong, Tommy·1978·Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
DOI 10.1016/0005-2760(78)90032-2
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Abstract

Regulation of cholesterol ester synthesis was studied in cultured C-6 glial and neuroblastoma cells. Particular emphasis was placed on the relation of this regulation to control of cholesterol synthesis. The effectors studied were low density lipoprotein (LDL) and desmosterol. Distinct differences in regulation were observed between the glial and neuronal cells. In the neuronal cells cholesterol ester synthesis (from [14C]oleate) was not affected by even high concentrations of LDL or desmosterol. In contrast, cholesterol ester synthesis was stimulated as much as 12-fold in the glial cells after just 5 h exposure to LDL or desmosterol. Cholesterol synthesis (from [14C]acetate) was inhibited in a simultaneous and quantitatively similar manner. Suitable experiments indicated that alterations in pool sizes of intermediates did not contribute to the genesis of the observed responses and suggested that LDL and desmosterol produced their effects by stimulating esterification of primarily endogenous cholesterol. The data may have major implications concerning the controlling metabolic events prior to and at the onset of myelination.

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Metadata

Authors
Volpe, J. J., Hennessy, S. W., & Wong, T.
Venue
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Publisher
Elsevier BV
Published
1978-03
Volume
528
Issue
3
Pages
424-435
ISSN
0005-2760
DOI
10.1016/0005-2760(78)90032-2
Cited by
19
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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