Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,724 · see citing works

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay

Bolton, A. E., & Hunter, W. M. (1973) · Biochemical Journal · doi:10.1042/bj1330529 · Cited by 3,269 · see citing works

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

Goldstein, L. J., & Brown, S. M. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004341 · Cited by 2,455 · see citing works

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

Goldstein, J. L., Basu, S. K., & Brown, M. S. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)98152-1 · Cited by 1,623 · see citing works

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

Goldstein, J. L., & Brown, M. S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42341-7 · Cited by 1,485 · see citing works

Regulation of Plasma Cholesterol by Lipoprotein Receptors

Brown, M. S., Kovanen, P. T., & Goldstein, J. L. (1981) · Science · doi:10.1126/science.6261329 · Cited by 947 · see citing works

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829 · see citing works

Lipoprotein receptors and cholesterol homeostasis

Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 755 · see citing works

Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34284-9 · Cited by 619 · see citing works

The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively‐charged LDL by macrophages

Brown, M. S., Basu, S. K., Falck, J. R., Ho, Y. K., & Goldstein, J. L. (1980) · Journal of Supramolecular Structure · doi:10.1002/jss.400130107 · Cited by 528 · see citing works

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes

Zannis, V. I., Breslow, J. L., Utermann, G., Mahley, R. W., Weisgraber, K. H., Havel, R. J., Goldstein, J. L., Brown, M. S., Schonfeld, G., Hazzard, W. R., et al. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38094-9 · Cited by 436 · see citing works

Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

Innerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433 · see citing works

Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy.

Pitas, R. E., Innerarity, T. L., Weinstein, J. N., & Mahley, R. W. (1981) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.1.3.177 · Cited by 389 · see citing works

Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.

Goldstein, J. L., Ho, Y. K., Brown, M. S., Innerarity, T. L., & Mahley, R. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85958-6 · Cited by 376 · see citing works

Altered Metabolism (In Vivo and In Vitro) of Plasma Lipoproteins after Selective Chemical Modification of Lysine Residues of the Apoproteins

Mahley, R. W., Innerarity, T. L., Weisgraber, K. H., & Oh, S. Y. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109518 · Cited by 316 · see citing works

Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes.

Basu, S., Ho, Y. K., Brown, M. S., Bilheimer, D. W., Anderson, R., & Goldstein, J. L. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34141-3 · Cited by 298 · see citing works

Atherogenic Hyperlipoproteinemia: The Cellular and Molecular Biology of Plasma Lipoproteins Altered by Dietary Fat and Cholesterol

Mahley, R. W. (1982) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31426-2 · Cited by 273 · see citing works

Characterization of the major apolipoproteins secreted by two human hepatoma cell lines

Zannis, V. I., Breslow, J. L., Sangiacomo, T. R., Aden, D. P., & Knowles, B. B. (1981) · Biochemistry · doi:10.1021/bi00528a006 · Cited by 258 · see citing works

Neuroscience approached through cell culture

Pfeiffer, S. E. (1982) · CRC Press eBooks · Cited by 253 · see citing works

Lipoprotein-receptor interactions

Innerarity, T. L., Pitas, R. E., & Mahley, R. W. (1986) · Methods in Enzymology · doi:10.1016/0076-6879(86)29091-6 · Cited by 186 · see citing works

Cell surface receptor binding of phospholipid . protein complexes containing different ratios of receptor-active and -inactive E apoprotein.

Pitas, R. E., Innerarity, T. L., & Mahley, R. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70808-4 · Cited by 173 · see citing works

Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins.

Koo, C., Innerarity, T. L., & Mahley, R. W. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38968-8 · Cited by 162 · see citing works

Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro.

Mahley, R. W., Innerarity, T. L., Weisgraber, K. H., & Fry, D. L. (1977) · PubMed Central · Cited by 159 · see citing works

Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia.

Fainaru, M., Mahley, R. W., Hamilton, R. L., & Innerarity, T. L. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38102-5 · Cited by 156 · see citing works

Foam cells in explants of atherosclerotic rabbit aortas have receptors for beta-very low density lipoproteins and modified low density lipoproteins.

Pitas, R. E., Innerarity, T. L., & Mahley, R. W. (1983) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.3.1.2 · Cited by 147 · see citing works

A Specific 37,000-Dalton Protein That Accumulates in Regenerating but Not in Nonregenerating Mammalian Nerves

Müller, H. W., Gebicke‐Haerter, P. J., Hangen, D. H., & Shooter, E. M. (1985) · Science · doi:10.1126/science.3983637 · Cited by 144 · see citing works

Formation of cholesterol- and apoprotein E-enriched high density lipoproteins in vitro.

Gordon, V. M., Innerarity, T. L., & Mahley, R. W. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32393-7 · Cited by 140 · see citing works

Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells. Requirements for homology for receptor binding activity.

Innerarity, T. L., Pitas, R. E., & Mahley, R. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70270-1 · Cited by 112 · see citing works

A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1

Weisgraber, K. H., Rall, S. C., Innerarity, T. L., Mahley, R. W., Kuusi, T., & Ehnholm, C. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111287 · Cited by 111 · see citing works

Organization of the cytoskeleton in resting, discoid platelets: preservation of actin filaments by a modified fixation that prevents osmium damage.

Boyles, J. K., Fox, J. E. B., Phillips, D. R., & Stenberg, P. E. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.4.1463 · Cited by 104 · see citing works

Apolipoprotein E is the determinant that mediates the receptor uptake of beta-very low density lipoproteins by mouse macrophages.

Innerarity, T. L., Arnold, K. S., Weisgraber, K. H., & Mahley, R. W. (1986) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.6.1.114 · Cited by 87 · see citing works

Delivery of aclacinomycin A to human glioma cells in vitro by the low-density lipoprotein pathway.

Rudling, M. J., Collins, V. P., & Peterson, C. O. (1983) · PubMed · Cited by 78 · see citing works

Expression of specific sheath cell proteins during peripheral nerve growth and regeneration in mammals.

Müller, H. W., Ignatius, M. J., Hangen, D. H., & Shooter, E. M. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.2.393 · Cited by 75 · see citing works

Development of accelerated atherosclerosis. Concepts derived from cell biology and animal model studies.

Rw, M. (1983) · PubMed · Cited by 69 · see citing works

THE COMPOSITION OF LIPIDS IN CEREBROSPINAL FLUID OF CHILDREN AND ADULTS

Illingworth, D. R., & Glover, J. (1971) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1971.tb12006.x · Cited by 53 · see citing works

Regulation of cholesterol ester synthesis in cultured glial and neuronal cells

Volpe, J. J., Hennessy, S. W., & Wong, T. K. (1978) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(78)90032-2 · Cited by 22 · see citing works

Distribution of radioactivity in myelin lipids following subcutaneous injection of [14C]stearate

Gozlan-Devillierre, N., Baumann, N., & Bourre, J. M. (1978) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(78)90039-5 · Cited by 17 · see citing works

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028 · see citing works

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Bu, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2620 · Cited by 1,168 · see citing works

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157 · see citing works

The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina

Lauritzen, L. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00017-5 · Cited by 1,066 · see citing works

Review Article: Genetics of Alzheimer Disease

Bekris, L. M., Yu, C.-E., Bird, T. D., & Tsuang, D. W. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710383571 · Cited by 1,029 · see citing works

Brain Cholesterol: Long Secret Life Behind a Barrier

Björkhem, I., & Meaney, S. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000120374.59826.1b · Cited by 1,044 · see citing works

Nanoparticulate systems for brain delivery of drugs.

Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107 · see citing works

Nanoparticulate systems for brain delivery of drugs

Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 958 · see citing works

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600549103 · Cited by 912 · see citing works

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006312 · Cited by 782 · see citing works

Cholesterol metabolism and homeostasis in the brain

Zhang, J., & Liu, Q. (2015) · Protein & Cell · doi:10.1007/s13238-014-0131-3 · Cited by 686 · see citing works

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., & Pitas, R. E. (1994) · Science · doi:10.1126/science.8171342 · Cited by 795 · see citing works

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

Wisniewski, T., & Frangione, B. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90444-c · Cited by 802 · see citing works

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

Kanekiyo, T., Xu, H., & Bu, G. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.045 · Cited by 608 · see citing works

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease.

Poirier, J., Delisle, M.-C., Quirion, R., Aubert, I., Farlow, M. R., Lahiri, D. K., Hui, S. L., Bertrand, P., Nalbantoglu, J. N., & Gilfix, B. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12260 · Cited by 593 · see citing works

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., & Weisgraber, K. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47945-8 · Cited by 714 · see citing works

A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier

Dehouck, B., Fénart, L., Dehouck, M., Pierce, A., Torpier, G., & Cecchelli, R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.877 · Cited by 568 · see citing works

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Björkhem, I., Lütjohann, D., Diczfalusy, U., Ståhle, L., Ahlborg, G., & Wahren, J. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32188-x · Cited by 538 · see citing works

Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism

Mahley, R. W. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.307023 · Cited by 516 · see citing works

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.

Boyles, J. K., Zoellner, C. D., Anderson, L. J., Kosik, L. M., Pitas, R. E., Weisgraber, K. H., Hui, D. Y., Mahley, R. W., Gebicke‐Haerter, P. J., & Ignatius, M. J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113943 · Cited by 533 · see citing works

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE

Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works

The apolipoprotein ε4 allele in patients with Alzheimer's disease

Mayeux, R. P., Stern, Y., Ottman, R., Tatemichi, T. K., Tang, M., Maestre, G. E., Ngai, C. I., Tycko, B., & Ginsberg, H. N. (1993) · Annals of Neurology · doi:10.1002/ana.410340527 · Cited by 414 · see citing works

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

Sanan, D. A., Weisgraber, K. H., Russell, S. J., Mahley, R. W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., & Roses, A. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117407 · Cited by 404 · see citing works

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

Holtzman, D. M., Santucci, D., Kilbridge, J., Chua-Couzens, J., Fontana, D. J., Daniels, S. E., Johnson, R. M., Chen, K., Sun, Y., Carlson, E., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13333 · Cited by 448 · see citing works

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

Lütjohann, D., Papassotiropoulos, A., Björkhem, I., Locatelli, S., Bagli, M., Oehring, R. D., Schlegel, U. S., Jessen, F., Rao, M. L., von Bergmann, K., et al. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32052-6 · Cited by 378 · see citing works

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain

Björkhem, I. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01725.x · Cited by 381 · see citing works

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

Poirier, J., Hess, M. A., May, P. C., & Finch, C. E. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90111-a · Cited by 380 · see citing works

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.

Linton, M. F., Gish, R., Hubl, S. T., Bütler, E., Esquivel, C., Bry, W. I., Boyles, J. K., Wardell, M. R., & Young, S. G. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115288 · Cited by 367 · see citing works

Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies

Chew, H., Solomon, V. A., & Fonteh, A. N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00598 · Cited by 353 · see citing works

Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids.

Schmitz, G., & Müller, G. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41642-6 · Cited by 350 · see citing works

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

Holtzman, D. M., Pitas, R. E., Kilbridge, J., Nathan, B., Mahley, R. W., Bu, G., & Schwartz, A. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9480 · Cited by 349 · see citing works

Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain

Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385 · see citing works

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Henstridge, C. M., Hyman, B. T., & Spires-Jones, T. L. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0113-1 · Cited by 348 · see citing works

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P. S., Manis, M., Schroeder, C., Yin, Z., Madore, C., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.024 · Cited by 334 · see citing works

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats

Poirier, J., Baccichet, A., Dea, D., & Gauthier, S. G. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90456-p · Cited by 329 · see citing works

Neuroinflammation: Modulation by flavonoids and mechanisms of action

Spencer, J. P. E., Vafeiadou, K., Williams, R. J., & Vauzour, D. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.016 · Cited by 315 · see citing works

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

Bellosta, S., Nathan, B. P., Orth, M., Dong, L.-M., Mahley, R. W., & Pitas, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27063 · Cited by 313 · see citing works

Cholesterol in brain disease: Sometimes determinant and frequently implicated

Martín, M. G., Pfrieger, F., & Dotti, C. G. (2014) · The EMBO Reports · doi:10.15252/embr.201439225 · Cited by 304 · see citing works

Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease

Martins, I. J., Hone, E., Foster, J. K., Sünram-Lea, S. I., Gnjec, A., Fuller, S. J., Nolan, D., Gandy, S. E., & Martins, R. N. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001854 · Cited by 388 · see citing works

Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein

Rebeck, G. W., Harr, S. D., Hyman, B. T., & Strickland, D. K. (1995) · Annals of Neurology · doi:10.1002/ana.410370212 · Cited by 294 · see citing works

Apolipoprotein E: From lipid transport to neurobiology

Hauser, P. S., Narayanaswami, V., & Ryan, R. O. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.09.001 · Cited by 320 · see citing works

Nascent astrocyte particles differ from lipoproteins in CSF

LaDu, M. J., Gilligan, S. M., Lukens, J. R., Cabana, V. G., Reardon, C. A., Van Eldik, L. J., & Holtzman, D. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052070.x · Cited by 285 · see citing works

Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration

Wang, L., Schuster, G. U., Hultenby, K. R., Zhang, Q., Andersson, S., & Gustafsson, J.-Α. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172510899 · Cited by 286 · see citing works

Importance of a Novel Oxidative Mechanism for Elimination of Brain Cholesterol

Björkhem, I., Lütjohann, D., Breuer, O., Sakinis, A., & Wennmalm, Å. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30178 · Cited by 281 · see citing works

Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model

Fryer, J. D., Simmons, K., Parsadanian, M., Bales, K. R., Paul, S. M., Sullivan, P. M., & Holtzman, D. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5170-04.2005 · Cited by 278 · see citing works

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease

Fernandez, C. G., Hamby, M. E., McReynolds, M. L., & Ray, W. J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00014 · Cited by 277 · see citing works

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

Nathan, B. P., Chang, K.-C., Bellosta, S., Brisch, E., Ge, N., Mahley, R. W., & Pitas, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19791 · Cited by 276 · see citing works

Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target

Ye, S., Huang, Y., Müllendorff, K., Dong, L., Giedt, G., Meng, E. C., Cohen, F. E., Kuntz, I. D., Weisgraber, K. H., & Mahley, R. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508693102 · Cited by 275 · see citing works

Cholesterol: its regulation and role in central nervous system disorders

Orth, M., & Bellosta, S. (2012) · Cholesterol · doi:10.1155/2012/292598 · Cited by 339 · see citing works

Why are stroke patients prone to develop dementia?

Pasquier, F., & Leys, D. (1997) · Journal of Neurology · doi:10.1007/s004150050064 · Cited by 253 · see citing works

Apolipoprotein E: Diversity of Cellular Origins, Structural and Biophysical Properties, and Effects in Alzheimer's Disease

Huang, Y., Weisgraber, K. H., Mucke, L., & Mahley, R. W. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:189 · Cited by 242 · see citing works

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

TOKUDA, T., CALERO, M., MATSUBARA, E., VIDAL, R., KUMAR, A., PERMANNE, B., ZLOKOVIC, B., SMITH, J. D., LADU, M. J., ROSTAGNO, A., et al. (2000) · Biochemical Journal · doi:10.1042/bj3480359 · Cited by 272 · see citing works

Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes.

Dehouck, B., Dehouck, M., Fruchart, J., & Cecchelli, R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.2.465 · Cited by 234 · see citing works

Microglial cells in astroglial cultures: a cautionary note

Saura, J. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-26 · Cited by 233 · see citing works

Apolipoprotein E and Alzheimer’s disease: Findings, hypotheses, and potential mechanisms

Koutsodendris, N., Nelson, M. R., Rao, A., & Huang, Y. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-030421-112756 · Cited by 231 · see citing works

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

Papassotiropoulos, A., Lütjohann, D., Bagli, M., Locatelli, S., Jessen, F., Buschfort, R., Ptok, U., Björkhem, I., von Bergmann, K., & Heun, R. (2002) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00050-4 · Cited by 231 · see citing works

24(S)-Hydroxycholesterol Participates in a Liver X Receptor-controlled Pathway in Astrocytes That Regulates Apolipoprotein E-mediated Cholesterol Efflux

Abildayeva, K., Jansen, P. J., Hirsch-Reinshagen, V., Bloks, V. W., Bakker, A. H. F., Ramaekers, F. C. S., de Vente, J., Groen, A. K., Wellington, Kuipers, F., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601019200 · Cited by 267 · see citing works

Alterations in cholesterol metabolism as a risk factor for developing Alzheimer’s disease: Potential novel targets for treatment

Loera‐Valencia, R., Goikolea, J., Parrado‐Fernández, C., Merino‐Serrais, P., & Maioli, S. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.03.003 · Cited by 228 · see citing works

Do oxysterols control cholesterol homeostasis?

Björkhem, I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16388 · Cited by 224 · see citing works

Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice

Fagan, A. M., Holtzman, D. M., Munson, G., Mathur, T., Schneider, D., Chang, L. K., Getz, G. S., Reardon, C. A., Lukens, J., Shah, J. A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30001 · Cited by 222 · see citing works

Apolipoprotein E receptors: linking brain development and alzheimer's disease

Herz, J., & Beffert, U. (2000) · Nature reviews. Neuroscience · doi:10.1038/35036221 · Cited by 218 · see citing works

Lipopolysaccharide-free conditions in primary astrocyte cultures allow growth and isolation of microglial cells

Gebicke‐Haerter, P. J., Bauer, J., Schobert, A., & Northoff, H. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-01-00183.1989 · Cited by 216 · see citing works

Oxidative Stress and Neurodegenerative Disorders

Sun, A. Y., & Chen, Y. (1998) · Journal of Biomedical Science · doi:10.1007/bf02255928 · Cited by 214 · see citing works

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice

Gong, J.-S., Kobayashi, M., Hayashi, H., Zou, K., Sawamura, N., Fujita, S. C., Yanagisawa, K., & Michikawa, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203934200 · Cited by 214 · see citing works

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

Bogdanović, N., Brétillon, L., Lund, E. G., Diczfalusy, U., Lannfelt, L., Winblad, B. G., Russell, D. W., & Björkhem, I. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02277-7 · Cited by 213 · see citing works

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

Sun, Y., Wu, S., Bu, G., Onifade, M. K., Patel, S. N., LaDu, M. J., Fagan, A. M., & Holtzman, D. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03261.1998 · Cited by 213 · see citing works

Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides

Laskowitz, D. T., Thekdi, A. D., Thekdi, S. D., Han, S. K. D., Myers, J. K., Pizzo, S. V., & Bennett, E. R. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7541 · Cited by 206 · see citing works

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

Huynh, T.-P. V., Liao, F., Francis, C. M., Robinson, G. O., Serrano, J. R., Jiang, H., Roh, J., Finn, M. B., Sullivan, P. M., Esparza, T. J., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.014 · Cited by 209 · see citing works

Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

Huynh, T.-P. V., Davis, A. A., Ulrich, J. D., & Holtzman, D. M. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r075481 · Cited by 210 · see citing works

Do oxysterols control cholesterol homeostasis?

Björkhem, I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216388 · Cited by 207 · see citing works

Cell type‐specific roles of APOE4 in Alzheimer disease

Blumenfeld, J., Yip, O., Kim, M. J., & Huang, Y. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00776-9 · Cited by 202 · see citing works

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

Najm, R., Jones, E. A., & Huang, Y. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0324-6 · Cited by 183 · see citing works

Apolipoproteins in the brain: implications for neurological and psychiatric disorders

Elliott, D. A., Weickert, C. S., & Garner, B. (2010) · Clinical Lipidology · doi:10.2217/clp.10.37 · Cited by 196 · see citing works

Oxidative Insults Are Associated with Apolipoprotein E Genotype in Alzheimer's Disease Brain

Ramassamy, C., Averill‐Bates, D. A., Beffert, U., Théroux, L., Lussier‐Cacan, S., Cohn, J. S., Christen, Y., Schoofs, A. R., Davignon, J., & Poirier, J. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0273 · Cited by 194 · see citing works

ApoE Lipidation as a therapeutic target in Alzheimer’s disease

Lanfranco, M. F., Ng, C. A., & Rebeck, G. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176336 · Cited by 189 · see citing works

Glial Lipoproteins Stimulate Axon Growth of Central Nervous System Neurons in Compartmented Cultures

Hayashi, H., Campenot, R. B., Vance, D. E., & Vance, J. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313828200 · Cited by 191 · see citing works

The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease

Beffert, U. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00008-3 · Cited by 188 · see citing works

Gene Transfer of Human <i>Apoe</i> Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

Hudry, E., Dashkoff, J., Roe, A. D., Takeda, S., Koffie, R. M., Hashimoto, T., Scheel, M., Spires-Jones, T., Arbel-Ornath, M., Betensky, R., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007000 · Cited by 187 · see citing works

Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease

Zalocusky, K. A., Najm, R., Taubes, A. L., Hao, Y., Yoon, S. Y., Koutsodendris, N., Nelson, M. R., Rao, A., Bennett, D. A., Bant, J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00851-3 · Cited by 189 · see citing works

Increased Risk of Late Posttraumatic Seizures Associated With Inheritance of APOE ϵ4 Allele

Diaz-Arrastia, R. R., Gong, Y., Fair, S., Scott, K. D., García, M. C., Carlile, M. C., Agostini, M. A., & Ness, P. C. V. (2003) · Archives of Neurology · doi:10.1001/archneur.60.6.818 · Cited by 186 · see citing works

Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development

Babin, P. J., Thisse, C., Durliat, M., Andre, M., Akimenko, M.-A., & Thisse, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8622 · Cited by 184 · see citing works

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J., Sullivan, P. M., Fagan, A. M., Han, X., & Holtzman, D. M. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00049-3 · Cited by 180 · see citing works

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.

Fagan, A. M., Bu, G., Sun, Y., Daugherty, A., & Holtzman, D. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.30121 · Cited by 226 · see citing works

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

Vance, J. E., & Hayashi, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.007 · Cited by 178 · see citing works

Specific Regional Transcription of Apolipoprotein E in Human Brain Neurons

Xu, P., Gilbert, J. R., Qiu, H.-L., Ervin, J. F., Rothrock‐Christian, T., Hulette, C., & Schmechel, D. E. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65305-9 · Cited by 177 · see citing works

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

Gasparini, L., Racchi, M., Binetti, G. G., Trabucchi, M., Solerte, S. B., Alkon, D. L., Etcheberrigaray, R., Gibson, G. E., Blass, J. P., Paoletti, R., et al. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.1.17 · Cited by 175 · see citing works

Polyunsaturated Fatty Acid Synthesis and Release

Moore, S. A. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:195 · Cited by 174 · see citing works

Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease

Huang, Y. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.04.004 · Cited by 170 · see citing works

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

Williams, T., Borchelt, D., & Chakrabarty, P. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-0358-9 · Cited by 166 · see citing works

Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein

Lorent, K., Overbergh, L., Moechars, D., Strooper, B. D., LEUVEN, F. V., & BERGHE, H. V. D. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00555-j · Cited by 170 · see citing works

Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein

Nathan, B. P., Jiang, Y., Wong, G. K., Shen, F., Brewer, G. J., & Struble, R. G. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03367-4 · Cited by 169 · see citing works

Apolipoprotein E and cholesterol in aging and disease in the brain

de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164 · see citing works

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

Rungta, R. L., Choi, H. B., Lin, P. J., Ko, R. W., Ashby, D., Nair, J., Manoharan, M., Cullis, P. R., & MacVicar, B. A. (2013) · Molecular Therapy—Nucleic Acids · doi:10.1038/mtna.2013.65 · Cited by 165 · see citing works

ApoE4 upregulates the activity of mitochondria‐associated ER membranes

Tambini, M. D., Pera, M., Kanter, E., Yang, H., Guardia‐Laguarta, C., Holtzman, D., Sulzer, D., Area‐Gomez, E., & Schon, E. A. (2016) · The EMBO Reports · doi:10.15252/embr.201540614 · Cited by 166 · see citing works

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

Farmer, B., Kluemper, J., & Johnson, L. (2019) · Cells · doi:10.3390/cells8020182 · Cited by 164 · see citing works

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

LaFerla, F. M., Troncoso, J. C., Strickland, D. K., Kawas, C. H., & Jay, G. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119536 · Cited by 162 · see citing works

More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration

Lane-Donovan, C., Philips, G. T., & Herz, J. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.005 · Cited by 158 · see citing works

Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice

Fagan, A. M., Holtzman, D. M., Munson, G., Mathur, T., Schneider, D., Chang, L. K., Getz, G. S., Reardon, C. A., Lukens, J., Shah, J. A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30001 · Cited by 222 · see citing works

Secretion of apolipoprotein E by an astrocytoma cell line

Krul, E. S., & Tang, J. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490320212 · Cited by 39 · see citing works

Astrocyte׳s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1

Ito, J., Nagayasu, Y., Miura, Y., Yokoyama, S., & Michikawa, M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.037 · Cited by 33 · see citing works

Inhibition of cholesterol synthesis increases secretion of apolipoprotein E (apoE) from human astrocytoma and liver hepatocyte cells

Patel, N. (2015) · Journal of Glycomics & Lipidomics

Regulation of apolipoprotein E secretion, lipidation and recycling in the central nervous system

Fan, J. (2014) · cIRcle (University of British Columbia) · doi:10.14288/1.0166830