Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394

Glutathione S-Transferases

Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42083-8 · Cited by 18,509

The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Weber, K., & Osborn, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94333-4 · Cited by 16,688

[30] Microsomal lipid peroxidation

Buege, J. A., & Aust, S. D. (1978) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(78)52032-6 · Cited by 13,564

Assay of proteins in the presence of interfering materials

Bensadoun, A., & Weinstein, D. (1976) · Analytical Biochemistry · doi:10.1016/s0003-2697(76)80064-4 · Cited by 3,191

Quantitative analysis of phospholipids by thin-layer chromatography

Skipski, V. P., Peterson, R., & Barclay, M. (1964) · Biochemical Journal · doi:10.1042/bj0900374 · Cited by 1,402

Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.

Kellogg, E. W., & Fridovich, I. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40745-x · Cited by 966

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

Hochstein, P. E., & Ernster, L. (1963) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(63)90111-6 · Cited by 536

Species, Tissue and Subcellular Distribution of Non Se-Dependent Glutathione Peroxidase Activity

Lawrence, R. A., & Burk, R. F. (1978) · Journal of Nutrition · doi:10.1093/jn/108.2.211 · Cited by 399

Lipid Peroxidation in Mitochondrial Membrane

VLADIMIROV, Y. A., Vi, O., Suslova, T. B., & Cheremisina, Z. P. (1980) · Advances in lipid research · doi:10.1016/b978-0-12-024917-6.50011-2 · Cited by 351

Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid–induced cytotoxicity

Ding, W., & Lind, S. E. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0608 · Cited by 41

The Nature of Antioxidant Defense Mechanisms: A Lesson from Transgenic Studies

Ho, Y., Magnenat, J.-L., Gargano, M. D., & Cao, J. (1998) · Environmental Health Perspectives · doi:10.2307/3433989 · Cited by 41

Effect of marchantins and related compounds on 5-lipoxygenase and cyclooxygenase and their antioxidant properties: a structure activity relationship study

Schwartner, C., Bors, W., Michel, C., Franck, U., Müller-Jakic, B., Nenninger, A., Asakawa, Y., & Wagner, H. (1995) · Phytomedicine · doi:10.1016/s0944-7113(11)80055-3 · Cited by 41

Cavernosal tissue nitrite, nitrate, malondialdehyde and glutathione levels in diabetic and non‐diabetic erectile dysfunction

Tuncayengin, A., Biri, H., Onaran, M., Şen, İ., Tuncayengin, Ö., Polat, F., Erbaş, D., & Bozkırlı, İ. (2003) · International Journal of Andrology · doi:10.1046/j.1365-2605.2003.00427.x · Cited by 41

Enzymatic determination of membrane lipid peroxidation

Maiorino, M., Roveri, A., Ursini, F., & Gregolin, C. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90119-9 · Cited by 41

Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis

Vučetić, M., Daher, B., Cassim, S., Meira, W., & Pouysségur, J. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02994-w · Cited by 40

Impact of selenium nanoparticles in the regulation of inflammation

Raza, A., Johnson, H., Singh, A., & Sharma, A. K. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109466 · Cited by 41

Targeting ferroptosis as novel therapeutic approaches for epilepsy

Jin, Y., Ren, L., Jing, X., & Wang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1185071 · Cited by 42

ARID3A enhances chemoresistance of pancreatic cancer via inhibiting PTEN-induced ferroptosis

Mao, X., Xu, J., Xiao, M., Chen, L., Hua, J., Liu, J., Wang, W., Yu, X., Meng, Q., & Shi, S. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103200 · Cited by 39

Targeting ferroptosis in autoimmune diseases: Mechanisms and therapeutic prospects

Zheng, Y., Yan, F., He, S., & Luo, L. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103640 · Cited by 42

Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy

Li, W., Sun, J., Zhou, X., Lu, Y., Cui, W., & Miao, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.780790 · Cited by 40

Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance

Storkey, C., Pattison, D. I., Ignasiak, M. T., Schiesser, C. H., & Davies, M. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.10.424 · Cited by 40

Lipid Peroxidation. An Overview

Comporti, M. (1993) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9116-5_6 · Cited by 39

Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells

Torres-Velarde, J. M., Allen, K. N., Salvador‐Pascual, A., Leija, R. G., Luong, D., Moreno-Santillán, D. D., Ensminger, D. C., & Vázquez‐Medina, J. P. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.04.208 · Cited by 44

Iron‐associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

Thorwald, M. A., Godoy-Lugo, J. A., Garcia, G., Silva, J. A., Kim, M., Christensen, A., Mack, W. J., Head, E., O’Day, P. A., Benayoun, B. A., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14541 · Cited by 40

ROS, thiols and thiol-regulating systems in male gametogenesis

Conrad, M., Ingold, I., Buday, K., Kobayashi, S., & Angeli, J. P. F. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.10.020 · Cited by 39

The role of ferroptosis in osteoarthritis: Progress and prospects

Sheng, W., Liao, S., Wang, D., Liu, P., & Zeng, H. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150683 · Cited by 37

HIF-1α alleviates ferroptosis in ulcerative colitis by regulation of GPX4

Hu, W., Cai, Y., Cai, D., Chen, Z., Huang, S., Zhang, S., Zhuang, H., Fang, T., & Chen, X. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07883-8 · Cited by 42

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

Shen, G., Liu, J., Wang, Y., Deng, Z., & Deng, F. (2025) · MedComm · doi:10.1002/mco2.70349 · Cited by 47

Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats

Kade, I. J., Borges, V. C., Savegnago, L., Ibukun, E. O., Zeni, G. R., Nogueira, C. W., & da Rocha, J. B. T. (2008) · Cell Biology and Toxicology · doi:10.1007/s10565-008-9095-5 · Cited by 37

Changes in biochemical parameters in rabbits blood after oral exposure to diphenyl diselenide for long periods

Bem, A. F. D., Portella, R. D. L., Perottoni, J., Becker, E. M., Bohrer, D., Paixão, M. W., Nogueira, C. W., Zeni, G. R., & da Rocha, J. B. T. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.04.005 · Cited by 37

Regulation of Glutathione Peroxidases

Flohé, L., Wingender, E., & Brigelius‐Flohé, R. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5981-8_17 · Cited by 38

NADH and NADPH inhibit lipid peroxidation promoted by hydroperoxides in rat liver microsomes

Cavallini, L., Valente, M., & Bindoli, A. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90132-7 · Cited by 37

Toxicity of Selenium Compounds and Nano‐Selenium Particles

Zhang, J., & Spallholz, J. E. (2009) · General, Applied and Systems Toxicology · doi:10.1002/9780470744307.gat243 · Cited by 37

Emerging roles of ferroptosis in infectious diseases

Bagayoko, S., & Meunier, É. (2021) · FEBS Journal · doi:10.1111/febs.16244 · Cited by 36

Glutathione depletion by methyl chloride and association with lipid peroxidation in mice and rats

Kornbrust, D. J., & Bus, J. S. (1984) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(84)90115-7 · Cited by 36

Relationship between oxidizable fatty acid content and level of antioxidant glutathione peroxidases in marine fish

Grim, J. M., Hyndman, K. A., Kriska, T., Girotti, A. W., & Crockett, E. L. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.058214 · Cited by 36

Noxious effects of oxygen reactive species on energy-coupling processes in Ehrlich ascites tumor mitochondria and the protection by pantothenic acid

Slyshenkov, V. S., Мойсеенок, А. Г., & Wojtczak, L. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02210-4 · Cited by 36

The Intestinal Redox System and Its Significance in Chemotherapy‐Induced Intestinal Mucositis

Yu, Q., Zhang, H., Guo, Y., Han, B., & Jiang, P. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7255497 · Cited by 36

Enzymatic and immunochemical evaluation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in testes and epididymal spermatozoa of rats of different ages

Tramer, F., Micali, F., Sandri, G., Bertoni, A., Lenzi, A., Gandini, L., & Panfili, E. (2002) · International Journal of Andrology · doi:10.1046/j.1365-2605.2002.00327.x · Cited by 35

Ferroptosis in aquaculture research

Xia, X., Cheng, Z., He, B., Liu, H., Liu, M., Hu, J., Lei, L., Wang, L., & Bai, Y. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736760 · Cited by 35

The Subcellular Location of Selenoproteins and the Impact on Their Function

Diamond, A. M. (2015) · Nutrients · doi:10.3390/nu7053938 · Cited by 38

Enhancement of Norway spruce bark side-streams: Modification of bioactive and protective properties of stilbenoid-rich extracts by UVA-irradiation

Välimaa, A., Raitanen, J., Tienaho, J., Sarjala, T., Nakayama, E., Korpinen, R. I., Mäkinen, S., Eklund, P., Willför, S. M., & Jyske, T. M. (2020) · Industrial Crops and Products · doi:10.1016/j.indcrop.2020.112150 · Cited by 37

Mitogen-Activated Protein Kinase OsMEK2 and OsMPK1 Signaling Is Required for Ferroptotic Cell Death in Rice–Magnaporthe oryzae Interactions

Dangol, S., Singh, R. P., Nguyen, K. N., Chen, Y., Wang, J., Lee, H. G., Hwang, B. K., & Jwa, N. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.710794 · Cited by 34

Ferroptosis As Ultimate Target of Cancer Therapy

Motooka, Y., & Toyokuni, S. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0048 · Cited by 36

Hypoxia-Induced Oxidative Stress in Health Disorders

Pialoux, V., & Mounier, R. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/940121 · Cited by 34

Ferroptosis: A new therapeutic target for bladder cancer

Zeng, F. J., Lan, Y., Wang, N., Huang, X., Zhou, Q., & Wang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1043283 · Cited by 35

Ferroptosis and pathogenesis of neuritic plaques in Alzheimer disease

Streit, W. J., Phan, L. T., & Bechmann, I. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.123.000823 · Cited by 36

Identification, sequencing and expression of selenium-dependent glutathione peroxidase transcript in the freshwater bivalve Unio tumidus exposed to Aroclor 1254

Doyen, P., Vasseur, P., & Rodius, F. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.07.002 · Cited by 33

A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage

Diechtierow, M., & Krauth‐Siegel, R. L. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.014 · Cited by 33

Thiol-dependent peroxidases care little about homology-based assignments of function

Flohé, L., Jaeger, T., Pilawa, S., & Sztajer, H. (2003) · Redox Report · doi:10.1179/135100003225002862 · Cited by 33

Effects of commercial selenium products on glutathione peroxidase activity and semen quality in stud boars

Petrujkić́, B., Šefer, D., Jovanović, I. B., Jovičin, M., Janković, S., Jakovljević, G., Beier, R. C., & Anderson, R. C. (2014) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2014.09.001 · Cited by 33

Effects of glutathione on the alpha-tocopherol-dependent inhibition of nuclear lipid peroxidation.

Tirmenstein, M. A., & Reed, D. J. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38298-5 · Cited by 33

Targeting ferroptosis offers therapy choice in sepsis-associated acute lung injury

Wang, Y., Wang, W., Zhang, Y., Fleishman, J. S., & Wang, H. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117152 · Cited by 37

Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies

Xia, S., Li, L., Shi, Z., Sun, N., & He, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1604652 · Cited by 33

Bilberry and Sea Buckthorn Leaves and Their Subcritical Water Extracts Prevent Lipid Oxidation in Meat Products

Mäkinen, S., Hellström, J., Mäki, M., Korpinen, R. I., & Mattila, P. H. (2020) · Foods · doi:10.3390/foods9030265 · Cited by 32

Ferroptosis: Shedding Light on Mechanisms and Therapeutic Opportunities in Liver Diseases

You, H., Wang, L., Bu, F., Meng, H., Huang, C., Fang, G.-Y., & Li, J. (2022) · Cells · doi:10.3390/cells11203301 · Cited by 33

Selenium status in infants and children with phenylketonuria and in maternal phenylketonuria

Lombeck, I., Jochum, F., & Terwolbeck, K. (1996) · European Journal of Pediatrics · doi:10.1007/pl00014232 · Cited by 32

Reduced glutathione effects on α‐tocopherol concentration of rat liver microsomes undergoing NADPH‐dependent lipid peroxidation

Graham, K. S., Reddy, C. C., & Scholz, R. W. (1989) · Lipids · doi:10.1007/bf02544533 · Cited by 32

Different effects of Triton X-100, deoxycholate, and fatty acids on the kinetics of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase

Maiorino, M., Roveri, A., Gregolin, C., & Ursini, F. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90369-3 · Cited by 32

Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

Fırat, Ö., Makay, Ö., Yenıay, L., Gökçe, G., Yenisey, Ç., & Çöker, A. (2017) · Annals of Surgical Treatment and Research · doi:10.4174/astr.2017.93.1.1 · Cited by 31

Ferroptosis in cardiovascular diseases: role and mechanism

Zhang, Q., Luo, Y., Peng, L., Rong, X., Liu, Y., Li, J., & Luo, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01169-2 · Cited by 33

Ebselen and diphenyl diselenide do not change the inhibitory effect of lead acetate on delta-aminolevulinate dehidratase

Perottoni, J., Meotti, F. C., Folmer, V., Pivetta, L. A., Nogueira, C. W., Zeni, G. R., & da Rocha, J. B. T. (2004) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2004.07.007 · Cited by 31

Selenoproteins of the glutathione system

Flohé, L., & Brigelius‐Flohé, R. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1609-5_14 · Cited by 31

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang, Y., Lin, Y., Han, Z., Wang, B., Zheng, W., & Wei, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1440309 · Cited by 32

Possible function of two insect phospholipid-hydroperoxide glutathione peroxidases

Li, D., Blàsevich, F., Theopold, U., & Schmidt, O. (2003) · Journal of Insect Physiology · doi:10.1016/s0022-1910(02)00189-0 · Cited by 30

High-performance liquid chromatography of hydroperoxy derivatives of stearoyllinoleoylphosphatidyl-choline and of their enzymatic reduction products

Ursini, F., Bonaldo, L., Maiorino, M., & Gregolin, C. S. (1983) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)96376-9 · Cited by 30

A matter of new life and cell death: programmed cell death in the mammalian ovary

Chesnokov, M. S., Mamedova, A. R., Zhivotovsky, B., & Kopeina, G. S. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01017-6 · Cited by 31

Role of ferroptosis in radiation-induced soft tissue injury

Berry, C. E., Kendig, C. B., An, N., Fazilat, A. Z., Churukian, A. A., Griffin, M., Pan, P. M., Longaker, M. T., Dixon, S. J., & Wan, D. C. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02003-5 · Cited by 33

Molecular cloning and oxidative stress response of a sigma-class glutathione S-transferase of the bumblebee Bombus ignitus

Kim, B. Y., Hui, W. L., Lee, K. S., Wan, H., Yoon, H. J., Gui, Z. Z., Chen, S., & Jin, B. R. (2010) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2010.09.012 · Cited by 30

Characterization of phospholipid hydroperoxide glutathione metabolizing peroxidase (gpx4) isoforms in Coho salmon olfactory and liver tissues and their modulation by cadmium

Wang, L., Harris, S. M., Espinoza, H. M., McClain, V., & Gallagher, E. P. (2012) · Aquatic Toxicology · doi:10.1016/j.aquatox.2012.02.025 · Cited by 29

Organic selenium in animal nutrition – utilisation, metabolism, storage and comparison with other selenium sources

Edens, F. W., & Sefton, A. E. (2016) · Journal of Applied Animal Nutrition · doi:10.1017/jan.2016.5 · Cited by 29

Human blood cells support the reduction of low-density-lipoprotein-associated cholesteryl ester hydroperoxides by albumin-bound ebselen

Christison, J. K., Sies, H., & Stocker, R. (1994) · Biochemical Journal · doi:10.1042/bj3040341 · Cited by 29

Membrane Antioxidants

Krinsky, N. I. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb22317.x · Cited by 29

Nanomaterial‐Triggered Ferroptosis and Cuproptosis in Cancer Therapy

Sahoo, S. S., & Manna, D. (2025) · Small · doi:10.1002/smll.202412462 · Cited by 28

Regulatory mechanisms of amino acids in ferroptosis

Yao, H., Jiang, W., Liao, X., Wang, D., & Zhu, H. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122803 · Cited by 29

Beyond Antioxidants: How Redox Pathways Shape Cellular Signaling and Disease Outcomes

Sulaiman, A. A., & Katanaev, V. L. (2025) · Antioxidants · doi:10.3390/antiox14091142 · Cited by 28

A Fluorescence Plate Reader Assay for Monitoring the Susceptibility of Biological Samples to Lipid Peroxidation

Tirmenstein, M. A., Pierce, C. A., Leraas, T. L., & Fariss, M. W. (1998) · Analytical Biochemistry · doi:10.1006/abio.1998.2907 · Cited by 27

Puberty influences expression of phospholipid hydroperoxide glutathione peroxidase (GPX4) in rat testis: Probable hypophysis regulation of the enzyme in male reproductive tract

Giannattasio, A., Girotti, M., Williams, K., Hall, L. N., & Bellastella, A. (1997) · Journal of Endocrinological Investigation · doi:10.1007/bf03347999 · Cited by 27

Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression

Hu, Y., Li, Z., Li, M., Wu, X., Zhang, S., Tang, M., Yu, R., Yang, M., Chen, X., Song, L., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.11.023 · Cited by 31

Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4

Janowski, R., Scanu, S., Niessing, D., & Madl, T. (2016) · Acta Crystallographica Section F Structural Biology Communications · doi:10.1107/s2053230x16013686 · Cited by 26

Mutant WDR45 Leads to Altered Ferritinophagy and Ferroptosis in β-Propeller Protein-Associated Neurodegeneration

Diaw, S. H., Ganos, C., Zittel, S., Plötze‐Martin, K., Kulikovskaja, L., Vos, M. H., Westenberger, A., Raković, A., Lohmann, K., & Dulovic‐Mahlow, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179524 · Cited by 26

Tissue localization and stage-specific expression of the phospholipid hydroperoxide glutathione peroxidase of Schistosoma mansoni

Roche‐Lestienne, C., Liu, J. L., LePresle, T., Capron, A., & Pierce, R. J. (1996) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(95)02523-5 · Cited by 26

Broadening horizons: the multifaceted role of ferroptosis in breast cancer

Ge, A., Wang, X., Li, Y., Da, Z., Chen, J., Daga, P., Dai, C. C., Yang, K., Yan, Y., Hao, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1455741 · Cited by 30

Ferroptosis, a new form of cell death defined after radiation exposure

Zhang, X., Li, X., Zheng, C., Yang, C., Zhang, R., Wang, A., Feng, J., Hu, X., Chang, S., & Zhang, H. (2022) · International Journal of Radiation Biology · doi:10.1080/09553002.2022.2020358 · Cited by 25

Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis

Li, L., & Zhu, Z. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1071844 · Cited by 26

Characterization and structural analysis of human selenium-dependent glutathione peroxidase 4 mutant expressed in Escherichia coli

Yu, Y., Song, J., Guo, X., Shuan, W., Yang, X., Chen, L., & Wei, J. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.032 · Cited by 25

PHGPx in spermatogenesis: how many functions?

Puglisi, R., Tramer, F., Carlomagno, G., Gandini, L., Panfili, E., Stefanini, M., Lenzi, A., Mangia, F., & Boitani, C. (2005) · Contraception · doi:10.1016/j.contraception.2005.03.002 · Cited by 25

Biological Effects of Oxidized Fatty Acids

Chow, C. K. (2007) · Food science and technology · doi:10.1201/9781420006902.ch36 · Cited by 25

Metabolism of arachidonic acid and other polyunsaturated fatty acids by blood vessels

Powell, W. S., & Funk, C. D. (1987) · Progress in Lipid Research · doi:10.1016/0163-7827(87)90003-8 · Cited by 25

Molecular Pathways Linking Oxylipins to Nociception in Rats

Domenichiello, A. F., Sapio, M. R., Loydpierson, A. J., Maric, D., Goto, T., Horowitz, M. S., Keyes, G. S., Yuan, Z., Majchrzak‐Hong, S. F., Mannes, A. J., et al. (2020) · Journal of Pain · doi:10.1016/j.jpain.2020.09.001 · Cited by 24

A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCTKO Pancreatic Ductal Adenocarcinoma Cells

Meira, W., Daher, B., Parks, S. K., Cormerais, Y., Durivault, J., Tambutté, É., Pouysségur, J., & Vučetić, M. (2021) · Cancers · doi:10.3390/cancers13061434 · Cited by 24

Niujiaodihuang Detoxify Decoction inhibits ferroptosis by enhancing glutathione synthesis in acute liver failure models

Ji, Y., Si, W., Zeng, J., Huang, L., Huang, Z., Zhao, L., Liu, J., Zhu, M., & Kuang, W. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114305 · Cited by 24

Photodynamic Therapy Initiated Ferrotherapy of Self-Delivery Nanomedicine to Amplify Lipid Peroxidation via GPX4 Inactivation

Zhao, L., Chen, S., Zheng, R., Rao, X., Kong, R., Huang, C., Liu, Y., Tang, Y., Cheng, H. B., & Li, S. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c15495 · Cited by 24

Reactive Sterol Electrophiles: Mechanisms of Formation and Reactions with Proteins and Amino Acid Nucleophiles

Porter, N. A., Xu, L., & Pratt, D. A. (2020) · Chemistry · doi:10.3390/chemistry2020025 · Cited by 28

Selenium Regulates Expression in Rat Liver of Genes for Proteins Involved in Iron Metabolism

Christensen, M. J., Olsen, C. A., Hansen, D. V., & Ballif, B. C. (2000) · Biological Trace Element Research · doi:10.1385/bter:74:1:55 · Cited by 24

Teratogenic effects of diphenyl diselenide in Wistar rats

Favero, A. M., Weis, S. N., Stangherlin, E. C., Zeni, G. R., da Rocha, J. B. T., & Nogueira, C. W. (2005) · Reproductive Toxicology · doi:10.1016/j.reprotox.2005.04.013 · Cited by 24

Organochalcogens Affect the Glutamatergic Neurotransmission in Human Platelets

Borges, V. C., Nogueira, C. W., Zeni, G. R., & da Rocha, J. B. T. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000029562.56942.5d · Cited by 24

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Xu, J., Zheng, B., Wang, W., & Zhou, S. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1417750 · Cited by 26

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Wu, S., Ga, Y., Ma, D., Hou, S., Hui, Q., & Hao, Z. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125118 · Cited by 26

Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc−/GSH/GPX4 axis

Yu, F., Zuo, J., Wang, M., Yu, S.-Y., Luo, K., Sha, T., Li, Q., Dong, Z.-C., Zhou, G., Zhang, F., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117569 · Cited by 23

Ferroptosis and microbial pathogenesis

Shen, Q., & Naqvi, N. I. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009298 · Cited by 23

Cloning of the mouse phospholipid hydroperoxide glutathione peroxidase gene1

Borchert, A., Schnurr, K., Thiele, B. J., & Kühn, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00221-5 · Cited by 23

In vitro effects of reactive O2 species on the β-receptor-adenylyl cyclase system

Schimke, I., Haberland, A., Will-Shahab, L., Küttner, I., & Papies, B. (1992) · Molecular and Cellular Biochemistry · doi:10.1007/bf02385004 · Cited by 23

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Xie, H., Cao, C., Shu, D., Liu, T., & Zhang, T. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1449037 · Cited by 23

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Li, X., Fang, M., Liu, X., Jiang, J., Wang, S., Mao, X., Zou, Z., & Jin, W. L. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02780-7 · Cited by 23

Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson’s disease increase cellular susceptibility to oxidative stress

Aguirre, C., Morale, M. C., Peng, Q., Sánchez-Alavez, M., Cintrón-Colón, R., Feng, K., Fazelpour, S., Maher, P. A., & Conti, B. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.007 · Cited by 21

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Qu, C., Peng, Y., & Liu, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.892957 · Cited by 22

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Li, C., Yin, X., Liu, Z., & Wang, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315031 · Cited by 24

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Wei, F., Zhou, J., Pan, L., Shen, M., Niu, D., Zeng, Z., Cheng, G., Yao, J., Zhang, G., & Sun, C. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118874 · Cited by 23

Effect of actinomycin D on the synthesis of DNA polymerase in hepatectomized rats

Giudice, G., & Novelli, G. D. (1963) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(63)90110-4 · Cited by 80

Purification of a cytosolic enzyme from human liver with phospholipid hydroperoxide glutathione peroxidase activity

Chambers, S. J., Lambert, N., & Williamson, G. (1994) · International Journal of Biochemistry · doi:10.1016/0020-711x(94)90097-3 · Cited by 20

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Ursini, F. (2019) · CRC Press eBooks · doi:10.1201/9780429289309-3

Purification and characterization of a novel monomeric glutathione peroxidase from rat liver.

Duan, Y., KOMURA, S., Fiszer‐Szafarz, B., Szafarz, D., & Yagi, K. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37381-2 · Cited by 48

Rat hepatic cytosolic glutathione-dependent enzyme protection against lipid peroxidation in the nadph-microsomal lipid peroxidation system

Burk, R. F., Trumble, M. J., & Lawrence, R. A. (1980) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(80)90051-x · Cited by 175