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Cited by 20Retinoids in leukemia and cellular processesCholesterol and Lipid MetabolismLipid metabolism and biosynthesis

Age-related variations in acyl-CoA: Retinol acyltransferase activity and vitamin A concentration in the liver and epidermis of hairless mice

Törmä, Hans, Brunnberg, Lena, Vahlquist, Anders·1987·Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
DOI 10.1016/0005-2760(87)90025-7
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Abstract

Since the factors regulating retinol esterification by acyl-CoA:retinol acyltransferase are poorly understood, we studied the age-related variations in acyl-CoA:retinol acyltransferase activity in hairless mice. Epidermis and liver were collected at intervals from birth to adolescence (0-6 weeks). Vitamin A was analyzed by high-performance liquid chromatography and acyl-CoA:retinol acyltransferase by an in vitro radioincubation assay of microsomes. Epidermal vitamin A (retinol plus retinyl esters) increased 8-10 times after birth and by the age of 3 weeks adult values were attained. This increase was accompanied by a 2-fold increase in acyl-CoA:retinol acyltransferase activity in the epidermis between 3 days and 6 weeks of age. In young animals the dependence of acyl-CoA:retinol acyltransferase on exogenous co-substrate (palmitoyl-CoA) was also lower than in adult animals. Although a pronounced age-related accumulation of retinol was recorded in the liver, the activity of acyl-CoA:retinol acyltransferase did not increase with age and there was no change in the dependence of acyl-CoA:retinol acyltransferase on exogenous palmitoyl-CoA.

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Crossref · 10.1016/0005-2760(87)90025-7

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19 of 19 references verified0 citation errors · 0 not checkable

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  • In mice, retinol esters accounted for 90% of the vitamin A in the epidermis, with retinol making up the remaining 10%.

    “A study in mice by Törmä et al. showed that retinol esters accounted for 90% of the vitamin A in the epidermis, with retinol making up the remaining 10% [39].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [39]

  • Retinol and retinyl esters exhibit a strong capacity to absorb ultraviolet radiation in the range of 300-350 nm.

    “Retinol and retinyl esters exhibit a strong capacity to absorb ultraviolet radiation in the range of 300–350 nm [39].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [39]

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Authors
Törmä, H., Brunnberg, L., & Vahlquist, A.
Affiliations
Uppsala University (SE)
ORCID
Törmä, Hans
Venue
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Publisher
Elsevier BV
Published
1987-09
Volume
921
Issue
2
Pages
254-258
ISSN
0005-2760 (ISSN-L)
DOI
10.1016/0005-2760(87)90025-7
OpenAlex
W2035958466
Cited by
20
References
19
Citations by year
2024: 1 · 2022: 1 · 2021: 1 · 2015: 1
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Psoriasis Association
  • Vetenskapsrådet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
retinol esterification, vitamin A, age-related changes, epidermis, liver, hairless mice, palmitoyl-CoA, retinyl esters, retinol, enzyme activity, developmental maturation
MeSH terms
Acyltransferases, Aging, Animals, Epidermis, Liver, Mice, Hairless, Microsomes, Microsomes, Liver, Palmitoyl Coenzyme A, Vitamin A, Retinol O-Fatty-Acyltransferase, Mice

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