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Discoidal complexes containing apolipoprotein E and their transformation by lecithin-cholesterol acyltransferase

Gong, Elaine L., Nichols, Alex V., Weisgraber, Karl H., Forte, Trudy M., Shore, Virgie G., Blanche, Patricia J.·1989·Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
DOI 10.1016/0005-2760(89)90019-2
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Abstract

The primary objectives of this study were to determine whether analogs to native discoidal apolipoprotein (apo)E-containing high-density lipoproteins (HDL) could be prepared in vitro, and if so, whether their conversion by lecithin-cholesterol acyltransferase (LCAT; EC 2.3.1.43) produced particles with properties comparable to those of core-containing, spherical, apoE-containing HDL in human plasma. Complexes composed of apoE and POPC, without and with incorporated unesterified cholesterol, were prepared by the cholate-dialysis technique. Gradient gel electrophoresis showed that these preparations contain discrete species both within (14-40 nm) and outside (10.8-14 nm) the size range of discoidal apoE-containing HDL reported in LCAT deficiency. The isolated complexes were discoidal particles whose size directly correlated with their POPC:apoE molar ratio: increasing this ratio resulted in an increase in larger complexes and a reduction in smaller ones. At all POPC:apoE molar ratios, size profiles included a major peak corresponding to a discoidal complex 14.4 nm long. Preparations with POPC:apoE molar ratios greater than 150:1 contained two distinct groups of complexes, also in the size range of discoidal apoE-containing HDL from patients with LCAT deficiency. Incorporation of unesterified cholesterol into preparations (molar ratio of 0.5:1, unesterified cholesterol:POPC) resulted in component profiles exhibiting a major peak corresponding to a discoidal complex 10.9 nm long.…

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Metadata

Authors
Gong, E. L., Nichols, A. V., Weisgraber, K. H., Forte, T. M., Shore, V. G., & Blanche, P. J.
Venue
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Publisher
Elsevier BV
Published
1989-12
Volume
1006
Issue
3
Pages
317-328
ISSN
0005-2760
DOI
10.1016/0005-2760(89)90019-2
Cited by
19
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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