Apoprotein (E–A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction
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In vitro studies have shown that the apoA-II and apoE heterodimeric complex on HDL cholesterol modulates receptor affinity for the LDL receptor, and that LDL receptor affinity is dependent on available apoE, probably dependent on apoE isoform.
“Previously, in vitro studies have shown that the apoA-II and apoE heterodimeric complex on HDL cholesterol modulates the receptor affinity for the LDL receptor, and that the LDL receptor affinity is dependent on available apoE, an affinity probably dependent on apoE isoform [124,125].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [124]
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- Havel, R. J., and Kane, J. P. (1973) Proc. Nutl. Acad. Sci. 70, 2015-2019
- Brewer, H. B., Jr., Lux, S. E., Ronan, R., and John, K. M. (1972) Proc. N&l. Acad. Sci. U. S. A. 69, 1304-1308
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- Authors
- Weisgraber, K. H., & Mahley, R. W.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Mahley, R.W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1978-09
- Volume
- 253
- Issue
- 17
- Pages
- 6281-6288
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1593464696
- Cited by
- 212
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2013: 2
- FWCI
- 23.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Child Health and Human Development
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, apolipoprotein A-II, mixed disulfides, disulfide bonds, high-density lipoprotein, HDL subfractions, serum lipoproteins, protein-protein interaction
- MeSH terms
- Amino Acids, Apolipoproteins, Disulfides, Electrophoresis, Polyacrylamide Gel, Immunodiffusion, Humans, Hyperlipidemias, Immunoelectrophoresis, Two-Dimensional, Lipoproteins, HDL, Molecular Weight
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