Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil
Abstract
A study was conducted to evaluate whether the composition of previous dietary fat affects the absorption and composition of lymph obtained after a meal of fish oil. Adult male Sprague-Dawley rats were fed diets containing either corn oil or fish oil (MaxEPA) for 2 weeks. They were then given intraduodenally a bolus of an emulsion of 0.5 ml of fish oil plus 0.5 ml of 20 mM sodium taurocholate. Intestinal lymph was collected from a cannula in the main intestinal lymph trunk for various times after oil administration. Rats proportion of the test dose fo fish oil than those fed corn oil. There was an effect of previous diet on the fatty acid composition of the lymph. Rats fed fish oil had a higher percentage of eicosapentaenoic and docosahexaenoic acids in the lymph lipids than those fed corn oil while those fed corn oil had a higher percentage of linoleic acid. These results rule out decreased intestinal absorption as a mechanism for the hypotriacylglycerolemic effect of dietary fish oils. They also indicate a significant contribution of endogenous lipids to the fatty acids in lymph.
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Fat absorption was not reduced and chylomicron lipids were cleared faster in fish oil-fed rats than in controls.
“Indeed, fat absorption was not reduced (30,31) and chylomicron lipids were cleared faster in fish oil-fed rats than in controls (32).”
From Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance (2003) · cites this paper as [30]
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References 18 · Cited by 21
- Authors
- Herzberg, G. R., Chernenko, G. A., Barrowman, J. A., Kean, K. T., & Keough, K. M. W.
- Affiliations
- Memorial University of Newfoundland (CA)
- Venue
- Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
- Publisher
- Elsevier BV
- Published
- 1992-03
- Volume
- 1124
- Issue
- 2
- Pages
- 190-194
- ISSN
- 0005-2760 (ISSN-L)
- OpenAlex
- W2034361752
- Cited by
- 21
- References
- 18
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- fish oil, intestinal absorption, dietary fat composition, corn oil, eicosapentaenoic acid, docosahexaenoic acid, linoleic acid, endogenous lipids, dietary adaptation
- MeSH terms
- Adaptation, Physiological, Animals, Corn Oil, Dietary Fats, Docosahexaenoic Acids, Fish Oils, Intestinal Absorption, Linoleic Acids, Lymph, Male, Rats, Inbred Strains, Eicosapentaenoic Acid, Linoleic Acid, Rats
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