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Stoichiometry of the reaction of oxyhemoglobin with nitrite
Abstract
During the reaction of oxyhemoglobin (HbO2) with nitrite, the concentration of residual nitrite, nitrate, oxygen, and methemoglobin (Hb+) was determined successively. The results obtained at various pH values indicate the following stoichiometry for the overall reaction: 4HbO2 + 4NO2- 4H+ leads to 4Hb+ + 4NO3- + O2 + 2H2 O (Hb denotes hemoglobin monomer). NO2- binds with methemoglobin noncooperatively with a binding constant of 340 M-1 at pH 7.4 and 25 degrees C. Thus, the major part of Hb+ produced is aquomethemoglobin, not methemoglobin nitrite, when less than 2 equivalents of nitrite is used for the oxidation.
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“the high concentrations of oxyhemoglobin usually found in the bloodstream can easily convert nitrite to nitrate [47,48].”
From Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension (2011) · cites this paper as [48]
Citations
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13. SULFUR AND NITROGEN OXIDES
Schlesinger, R. B., Chen, L., & Zelikoff, J. T. (2000)
Metadata
- Authors
- Kosaka, H., Imaizumi, K., Imai, K., & Tyuma, I.
- Affiliations
- The University of Osaka (JP)
- ORCID
- Imaizumi, Kazuhiko
- Venue
- Biochimica et Biophysica Acta (BBA) - Protein Structure
- Publisher
- Elsevier BV
- Published
- 1979-11
- Volume
- 581
- Issue
- 1
- Pages
- 184-188
- ISSN
- 0005-2795 (ISSN-L)
- OpenAlex
- W2077180688
- Cited by
- 139
- References
- 5
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Protein Structure (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Keywords
- oxyhemoglobin, nitrite, methemoglobin, hemoglobin oxidation, reaction stoichiometry, non-cooperative binding, pH dependence, nitrate
- MeSH terms
- Hemoglobin A, Humans, Hydrogen-Ion Concentration, Kinetics, Methemoglobin, Nitrites, Oxyhemoglobins
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