Cited by 294Protease and Inhibitor MechanismsCalpain Protease Function and RegulationUbiquitin and proteasome pathways

The place of human γ-trace (cystatin C) amongst the cysteine proteinase inhibitors

Barrett, Alan J., Davies, M.Elisabeth, Grubb, Anders·1984·Biochemical and Biophysical Research Communications

Abstract

Native gamma-trace, a small basic protein present in high concentration in cerebrospinal fluid, semen and neuroendocrine cells, but of unknown biological function, is shown to be a potent inhibitor of the cysteine proteinases papain, ficin, and human cathepsins B, H and L. It proves to be the tightest -binding protein inhibitor of cathepsin B so far discovered. The name cystatin C is proposed for gamma-trace to reflect the many similarities in activity and structure to chicken egg-white cystatin and mammalian cystatins A and B. The inhibition constants of cystatin C, taken together with its widespread distribution in human tissues and extracellular fluids, suggest that a physiological function could well be the regulation of cysteine proteinase activity.

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Crossref · 10.1016/0006-291x(84)91302-0

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Authors
Barrett, A. J., Davies, M. E., & Grubb, A.
Affiliations
  • University of Cambridge (GB)
  • Lund University (SE)
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1984-04
Volume
120
Issue
2
Pages
631-636
ISSN
0006-291X (ISSN-L)
OpenAlex
W1984079474
Cited by
294
References
28
Citations by year
2025: 3 · 2024: 7 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 12 · 2012: 2
FWCI
8.15
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
cystatin C, cysteine protease inhibitors, papain, ficin, cathepsin B, cathepsin H, cathepsin L, tight-binding inhibition, cerebrospinal fluid, cystatin A, cystatin B
MeSH terms
Epitopes, Cathepsins, Drug Stability, Ficain, Humans, Kinetics, Papain, Protease Inhibitors, Proteins, Cystatins, Cystatin C

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