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A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation

Reibel, L., Dorseuil, O., Stancou, R., Bertoglio, J., Gacon, G.·1991·Biochemical and Biophysical Research Communications
DOI 10.1016/0006-291x(91)91585-z
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Abstract

We have isolated, from a human B cell line cDNA library, a cDNA (Gx) encoding a small G protein identical to rac 2, a member of the ras superfamily. Gx/rac 2 gene is expressed as a unique mRNA of 1,7 Kb in peripheral blood lymphocytes, in purified B and T cells, in thymus as well as in several B and T cell lines. It is not expressed in many other tissues analysed including liver, brain, lung, heart and kidney. Upon in vitro stimulation with phytohemagglutinin A, peripheral blood lymphocytes show a clear increase of the Gx/rac 2 mRNA after 6 hours; a 30-50 fold accumulation is reached at 24 hours and persists thereafter. Purified T lymphocytes exhibit a similar increase in Gx/rac 2 mRNA expression upon mitogenic stimulation. Therefore, the expression of the Gx/rac 2 gene appears to be restricted to cells of the hemopoietic lineage and to be strongly stimulated during T cell activation. Gx/rac 2 protein must fulfill a specific role in activated T cells that could provide a new model for studying the function of small G proteins.

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Research works printed but not linked: 29

  1. Barbacid, 1987, Ann. Rev. Biochem, 56, 779, 10.1146/annurev.bi.56.070187.004023 · DOI · Paper page
  2. Hall, 1990, Science, 249, 635, 10.1126/science.2116664 · DOI
  3. Lowe, 1987, Cell, 48, 137, 10.1016/0092-8674(87)90364-3 · DOI
  4. Touchot, 1987, 84, 8210
  5. Zahraoui, 1988, Nucleic Acid Res, 16, 1204, 10.1093/nar/16.3.1204 · DOI
  6. Chardin, 1986, EMBO J, 5, 2203, 10.1002/j.1460-2075.1986.tb04485.x · DOI · Paper page
  7. Pizon, 1988, Oncogene, 3, 201
  8. Madaule, 1985, Cell, 41, 31, 10.1016/0092-8674(85)90058-3 · DOI
  9. De Vos, 1988, Science, 239, 888, 10.1126/science.2448879 · DOI
  10. Bos, 1988, Mutation Research, 195, 255, 10.1016/0165-1110(88)90004-8 · DOI
  11. Downward, 1990, Nature, 346, 719, 10.1038/346719a0 · DOI
  12. Chardin, 1989, The EMBO J, 8, 1087, 10.1002/j.1460-2075.1989.tb03477.x · DOI
  13. Segev, 1988, Cell, 52, 915, 10.1016/0092-8674(88)90433-3 · DOI
  14. Goud, 1988, Cell, 53, 753, 10.1016/0092-8674(88)90093-1 · DOI
  15. Plutner, 1990, The EMBO J, 9, 2375, 10.1002/j.1460-2075.1990.tb07412.x · DOI
  16. Haubruck, 1989, The EMBO Journal, 8, 1427, 10.1002/j.1460-2075.1989.tb03524.x · DOI
  17. Goud, 1990, Nature, 345, 553, 10.1038/345553a0 · DOI
  18. Didsbury, 1989, J. Biol. Chem, 264, 16378, 10.1016/S0021-9258(19)84716-6 · DOI · Paper page
  19. Wakasugi, 1987, 84, 804
  20. Sanger, 1977, 74, 5463
  21. Chirgwin, 1979, Biochemistry, 18, 5294, 10.1021/bi00591a005 · DOI
  22. Sigal, 1986, 83, 4725
  23. Shirsat, 1990, Oncogene, 5, 769
  24. Olofsson, 1988, Oncogene, 3, 231
  25. Crabtree, 1990, Science, 243, 355, 10.1126/science.2783497 · DOI
  26. Bourne, 1988, Cell, 53, 669, 10.1016/0092-8674(88)90081-5 · DOI
  27. Garrett, 1989, J. Biol. Chem, 264, 10, 10.1016/S0021-9258(17)31215-2 · DOI
  28. Kupfer, 1984, J. Immunol, 133, 2762, 10.4049/jimmunol.133.5.2762 · DOI
  29. Poo, 1988, Nature, 332, 378, 10.1038/332378a0 · DOI

Cited by

Metadata

Authors
Reibel, L., Dorseuil, O., Stancou, R., Bertoglio, J., & Gacon, G.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1991-03
Volume
175
Issue
2
Pages
451-458
ISSN
0006-291X
DOI
10.1016/0006-291x(91)91585-z
Cited by
43
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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