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Cited by 383Cytokine Signaling Pathways and InteractionsImmune cells in cancerImmune Response and Inflammation

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

Cunha, F.Q., Mohcada, S., Liew, F.Y.·1992·Biochemical and Biophysical Research Communications
DOI 10.1016/0006-291x(92)91852-h
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Abstract

A murine macrophage cell line, J774, expresses high levels of the enzyme nitric oxide synthase (NOS) and produces large amounts of nitric oxide (NO) when activated with recombinant interferon (IFN)-gamma and a low concentration of LPS (10 ng/ml). Both the expression of NOS and the production of NO were inhibited by recombinant IL-10 in a dose-dependent manner. The inhibition was effective only when the cells were pretreated with IL-10; addition of IL-10 at the same time or after IFN-gamma activation was without effect. These results demonstrate that IL-10, a product of Th2 (helper T lymphocyte 2) cells, can antagonise the function of IFN-gamma, a product of Th1 cells, by modulating the mechanism of synthesis of nitric oxide in the macrophages.

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Crossref · 10.1016/0006-291x(92)91852-h

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Citations

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Research works printed but not linked: 3

  1. Mosmann, 1989, Ann. Rev. Immunol, 145, 73
  2. Gajewski, 1991, Immunol. Rev, 142, 19
  3. Gazzinelli, R. T., Oswald, I. P., James, S. L. and Sher, A. J. Immunol. (in press)

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Metadata

Authors
Cunha, F. Q., Mohcada, S., & Liew, F. Y.
Affiliations
  • Wellcome Trust (GB)
  • University of Glasgow (GB)
Corresponding author
Liew, F.Y.
ORCID
Cunha, F.Q.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1992-02
Volume
182
Issue
3
Pages
1155-1159
ISSN
0006-291X (ISSN-L)
DOI
10.1016/0006-291x(92)91852-h
OpenAlex
W2038992843
Cited by
383
References
23
Citations by year
2026: 4 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 5
FWCI
11.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
IL-10, interferon-gamma, nitric oxide synthase, nitric oxide, macrophages, J774 cells, lipopolysaccharide, Th1/Th2 balance, cytokine antagonism, macrophage activation
MeSH terms
Amino Acid Oxidoreductases, Animals, Cell Line, Enzyme Induction, Interferon-gamma, Kinetics, Macrophages, Nitric Oxide, Recombinant Proteins, Interleukin-10, Nitric Oxide Synthase, Mice

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