Cited by 383Cytokine Signaling Pathways and InteractionsImmune cells in cancerImmune Response and Inflammation

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

Cunha, F.Q., Mohcada, S., Liew, F.Y.·1992·Biochemical and Biophysical Research Communications

Open this paper in CoChat — free account

Abstract

A murine macrophage cell line, J774, expresses high levels of the enzyme nitric oxide synthase (NOS) and produces large amounts of nitric oxide (NO) when activated with recombinant interferon (IFN)-gamma and a low concentration of LPS (10 ng/ml). Both the expression of NOS and the production of NO were inhibited by recombinant IL-10 in a dose-dependent manner. The inhibition was effective only when the cells were pretreated with IL-10; addition of IL-10 at the same time or after IFN-gamma activation was without effect. These results demonstrate that IL-10, a product of Th2 (helper T lymphocyte 2) cells, can antagonise the function of IFN-gamma, a product of Th1 cells, by modulating the mechanism of synthesis of nitric oxide in the macrophages.

Integrity signals

Registry

Crossref · 10.1016/0006-291x(92)91852-h

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
Ding, A. H., Nathan, C., & Stuehr, D. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2407 · Cited by 2,840
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.
Fiorentino, D. F., Bond, M. W., & Mosmann, T. R. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.6.2081 · Cited by 2,733
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.
Malefyt, R. D. W., Haanen, J. B. A. G., Spits, H., Roncarolo, M., Velde, A. A. T., Figdor, C. G., Johnson, K., KASTELEIN, R. A., Yssel, H., & de Vries, J. E. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.4.915 · Cited by 1,930
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
Fiorentino, D. F., Zlotnik, A., Vieira, P., Mosmann, T. R., Howard, M., Moore, K. W., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.10.3444 · Cited by 1,866
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.
Heinzel, F. P., Sadick, M. D., Holaday, B. J., Coffman, R. L., & Locksley, R. M. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.1.59 · Cited by 1,454
Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI
Moore, K. W., Vieira, P., Fiorentino, D. F., Trounstine, M. L., Khan, T. A., & Mosmann, T. R. (1990) · Science · doi:10.1126/science.2161559 · Cited by 1,143
Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase
Feelisch, M., & Noack, E. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90493-6 · Cited by 887
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.
Scott, P., Natovitz, P., Coffman, R. L., Pearce, E. J., & Sher, A. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.5.1675 · Cited by 705
Macrophage deactivating factor and transforming growth factors- beta 1 - beta 2 and - beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.
Ding, A. H., Nathan, C., Graycar, J. L., Derynck, R., Stuehr, D. J., & Srimal, S. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.3.940 · Cited by 500

Show all 23 references

Research works printed but not linked: 3

Mosmann, 1989, Ann. Rev. Immunol, 145, 73
Gajewski, 1991, Immunol. Rev, 142, 19
Gazzinelli, R. T., Oswald, I. P., James, S. L. and Sher, A. J. Immunol. (in press)

Sorted by citations

Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
Arango Duque, G., & Descoteaux, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00491 · Cited by 2,708
Biology and therapeutic potential of interleukin-10
Saraiva, M., Vieira, P., & O’Garra, A. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190418 · Cited by 1,157
Inflammatory Mediators of Asthma: An Update
Barnes, P. J., Chung, K. F., & Page, C. P. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01381-4 · Cited by 715
Cytokines in asthma
Chung, K. F., & Barnes, P. J. (1999) · Thorax · doi:10.1136/thx.54.9.825 · Cited by 654
Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines
Modolell, M., Corraliza, I. M., Link, F., Soler, G., & Eichmann, K. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250436 · Cited by 554
Properties and Functions of Interleukin-10
Mosman, T. R. (1994) · Advances in immunology · doi:10.1016/s0065-2776(08)60449-6 · Cited by 495
Isoforms of nitric oxide synthase
Förstermann, U., Gath, I., Schwarz, P., Closs, E. I., & Kleinert, H. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00181-6 · Cited by 477
Nitric oxide synthase: expression and expressional control of the three isoforms
F�rstermann, U., & Kleinert, H. (1995) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00172772 · Cited by 462
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease
Boughton-Smith, N. K., Evans, S., Whittle, B. J. R., Moncada, S., Hawkey, C. J., COLE, A. T., & Balsitis, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)91476-3 · Cited by 459
Nitric oxide and lung disease.
Barnes, P. J., & Belvisi, M. G. (1993) · Thorax · doi:10.1136/thx.48.10.1034 · Cited by 433
Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.
Anstey, N. M., Weinberg, J. B., Hassanali, M. Y., Mwaikambo, E. D., Manyenga, D., Misukonis, M. A., Arnelle, D. R., Hollis, D. R., McDonald, M., & Granger, D. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.557 · Cited by 431
IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes.
Lacraz, S. F., Nicod, L. P., Chicheportiche, R., Welgus, H. G., & Dayer, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118286 · Cited by 430
The Interleukin-10 Signal Transduction Pathway and Regulation of Gene Expression in Mononuclear Phagocytes
Donnelly, R. P., Dickensheets, H. L., & Finbloom, D. S. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313695 · Cited by 412
Systemically Administered Interleukin-10 Reduces Tumor Necrosis Factor-Alpha Production and Significantly Improves Functional Recovery Following Traumatic Spinal Cord Injury in Rats
Bethea, J. R., Nagashima, H., Acosta, M. F. C., BRICENO, C., GOMEZ, F., Marcillo, A. E., Loor, K. E., Green, J. B. A., & Dietrich, W. D. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.851 · Cited by 402
Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury
Deng, J., Kohda, Y., Chiao, H., Wang, Y., Hu, X., Hewitt, S. M., Miyaji, T., McLeroy, P., Nibhanupudy, B., Li, S., et al. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00043.x · Cited by 398
Feedback inhibition of nitric oxide synthase activity by nitric oxide
Assreuy, J., Cunha, F. Q., Liew, F. Y., & Moncada, S. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb12886.x · Cited by 389
Self-citation
Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.
Sakurai, H., Kohsaka, H., Liu, M. F., Higashiyama, H., Hirata, Y., Kanno, K., Saito, I., & Miyasaka, N. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118292 · Cited by 388
Modulation of Macrophage Function by Transforming Growth Factor β, Interleukin‐4, and Interleukin‐10a
Bogdan, C., & Nathan, C. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35934.x · Cited by 379
Immunobiology of Asthma
Hamid, Q. A., & Tulić, M. K. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163200 · Cited by 377
Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells
Taylor-Robinson, A. W., Liew, F. Y., Severn, A., Xu, D., McSorley, S. J., Garside, P., Padron, J., & PHILLIPS, R. S. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240430 · Cited by 370
Self-citation
Nitric oxide and virus infection
Akaike, T., & Maeda, H. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00142.x · Cited by 362
In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.
Karp, C. L., EL-Safi, S. H., Wynn, T. A., Satti, M. M., Kordofani, A. M., Hashim, F. A., Hag-Ali, M., Neva, F. A., Nutman, T. B., & Sacks, D. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116372 · Cited by 338
Immunology of Leishmaniasis
Liew, F. Y., & O’Donnell, C. A. (1993) · Advances in Parasitology/Advances in parasitology · doi:10.1016/s0065-308x(08)60208-0 · Cited by 334
Self-citation
IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-α, TGF-β1 and blood–brain barrier function
Csuka, E., Morganti-Kossmann, M. C., Lenzlinger, P. M., Joller, H., Trentz, O., & Kossmann, T. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00148-4 · Cited by 325
Cordycepin: A bioactive metabolite with therapeutic potential
Tuli, H. S., Sharma, A. K., Sandhu, S. S., & Kashyap, D. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.09.030 · Cited by 330
The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells
Eizirik, D. L., Flodström‐Tullberg, M., Karlsen, A. E., & Welsh, N. (1996) · Diabetologia · doi:10.1007/bf00403906 · Cited by 316
Macrophages and post-burn immune dysfunction
Schwacha, M. G. (2003) · Burns · doi:10.1016/s0305-4179(02)00187-0 · Cited by 309
Macrophages in tuberculosis: friend or foe
Guirado, E., Schlesinger, L. S., & Kaplan, G. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0388-2 · Cited by 331
Protection against acetaminophen-induced liver injury and lethality by interleukin 10: Role of inducible nitric oxide synthase
Bourdi, M., Masubuchi, Y., Reilly, T. P., Amouzadeh, H. R., Martin, J. L., George, J. W., Shah, A. G., & Pohl, L. R. (2002) · Hepatology · doi:10.1053/jhep.2002.30956 · Cited by 304
Pro- versus anti-inflammatory cytokines: myth or reality.
Cavaillon, J. (2001) · PubMed · Cited by 301
Annexin 1: more than an anti-phospholipase protein
Parente, L., & Solito, E. (2004) · Inflammation Research · doi:10.1007/s00011-003-1235-z · Cited by 288
Autoimmune thyroid disease: new models of cell death in autoimmunity
Stassi, G., & Maria, R. D. (2002) · Nature reviews. Immunology · doi:10.1038/nri750 · Cited by 279
Glomerular actions of nitric oxide
Raij, L. R., & Baylis, C. (1995) · Kidney International · doi:10.1038/ki.1995.262 · Cited by 262
Interleukin‐10 inhibition of the progression of established collagen‐induced arthritis
Walmsley, M. J., Katsikis, P. D., Abney, E. R., Parry, S., Williams, R. O., Maini, R. N., & Feldmann, M. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390318 · Cited by 257
Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?
Sasindran, S. J., & Torrelles, J. B. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00002 · Cited by 259
Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon γ
Zdanov, A. S., Schalk‐Hihi, C., Gustchina, A., Tsang, M., Weatherbee, J. A., & Wlodawer, A. (1995) · Structure · doi:10.1016/s0969-2126(01)00193-9 · Cited by 235
The polarization of Th1/Th2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production
Murata, Y., Shimamura, T., & Hamuro, J. (2002) · International Immunology · doi:10.1093/intimm/14.2.201 · Cited by 232
The Role of the l-arginine: Nitric Oxide Pathway in Circulatory Shock
Thiemermann, C. (1994) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60493-7 · Cited by 220
Targeting the host inflammatory response in traumatic spinal cord injury
Bethea, J. R., & Dietrich, W. D. (2002) · Current Opinion in Neurology · doi:10.1097/00019052-200206000-00021 · Cited by 219
Relationship of Interleukin-10 Plasma Levels to Severity of Injury and Clinical Outcome in Injured Patients
Neidhardt, R., Keel, M. J. B., Steckholzer, U., Safret, A., Ungethuem, U., Trentz, O., & Ertel, W. (1997) · doi:10.1097/00005373-199705000-00017 · Cited by 217
IL‐13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells
Chibana, K., Trudeau, J. B., Mustovich, A. T., Hu, H., Zhao, J., Balzar, S., Chu, H. W., & Wenzel, S. E. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.02969.x · Cited by 218
Role of free radicals in viral pathogenesis and mutation
Akaike, T. (2001) · Reviews in Medical Virology · doi:10.1002/rmv.303 · Cited by 207
Anti‐inflammatory cytokines in asthma and allergy: interleukin‐10, interleukin‐12, interferon‐γ
Chung, K. F. (2001) · Mediators of Inflammation · doi:10.1080/09629350120054518 · Cited by 195
The immunomodulatory factors of bloodfeeding arthropod saliva
Gillespie, Mbow, & Titus, R. G. (2000) · Parasite Immunology · doi:10.1046/j.1365-3024.2000.00309.x · Cited by 188
Role of IL-10 in the Resolution of Airway Inflammation
Ogawa, Y., Duru, E. A., & Ameredes, B. T. (2008) · Current Molecular Medicine · doi:10.2174/156652408785160907 · Cited by 185
Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.
Mertz, P. M., DeWitt, D. L., Stetler‐Stevenson, W. G., & Wahl, L. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31965-8 · Cited by 178
Initial Cytokine Exposure Determines Function of Macrophages and Renders Them Unresponsive to Other Cytokines
Erwig, L., Kluth, D., Walsh, G. M., & Rees, A. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.4.1983 · Cited by 178
Therapy of cancer metastasis by activation of the inducible nitric oxide synthase
Xie, K., & Fidler, I. J. (1998) · Cancer and Metastasis Reviews · doi:10.1023/a:1005956721457 · Cited by 178
Role of Nitric Oxide in the Failure of Neutrophil Migration in Sepsis
Benjamim, C. F., Ferreira, S. H., & Cunha, F. Q. (2000) · The Journal of Infectious Diseases · doi:10.1086/315682 · Cited by 171
Self-citation
Arginase-2 is Essential for IL-10 Metabolic Reprogramming of Inflammatory Macrophages at the Mitochondria
Dowling, J. K., Afzal, R., Gearing, L. J., Cervantes‐Silva, M. P., Annett, S., Davis, G. M., Santi, C. D., Aßmann, N., Dettmer, K., Gough, D. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-021-21617-2 · Cited by 178
Interleukin‐10 and interleukin‐4 inhibit intracellular killing of Leishmania infantum and Leishmania major by human macrophages by decreasing nitric oxide generation
Vouldoukis, I., Bécherel, P., Riveros‐Moreno, V., Arock, M., Silva, O. D., Debré, P., Mazier, D., & Mossalayi, M. D. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270409 · Cited by 167
Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets
Tezel, G. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100998 · Cited by 175
Regulation of lymphocyte functions by nitric oxide
Liew, F. Y. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80116-2 · Cited by 163
Self-citation
The Therapeutic Role of Interleukin-10 after Spinal Cord Injury
Thompson, C. D., Zurko, J. C., Hanna, B. F., Hellenbrand, D. J., & Hanna, A. S. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2651 · Cited by 163
PersistentCryptococcus neoformansPulmonary Infection in the Rat Is Associated with Intracellular Parasitism, Decreased Inducible Nitric Oxide Synthase Expression, and Altered Antibody Responsiveness to Cryptococcal Polysaccharide
Goldman, D. L., Lee, S. C., Mednick, A. J., Montella, L., & Casadevall, A. (2000) · Infection and Immunity · doi:10.1128/iai.68.2.832-838.2000 · Cited by 156
Down-Modulation of Lung Immune Responses by Interleukin-10 and Transforming Growth Factor β (TGF-β) and Analysis of TGF-β Receptors I and II in Active Tuberculosis
Bonecini-Almeida, M. D. G., Ho, J. L., Boéchat, N., Huard, R. C., Chitale, S., Doo, H., Geng, J., Rego, L., Lazzarini, L. C. O., Kritski, A. L., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.5.2628-2634.2004 · Cited by 155
Progesterone inhibits inducible nitric oxide synthase gene expression and nitric oxide production in murine macrophages
Miller, L. D., Alley, E. W., Murphy, W. J., Russell, S. W., & Hunt, J. S. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.3.442 · Cited by 152
Role of Complement, Chemokines, & Regulatory Cytokines in Acute Lung Injury
Ward, P. A. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32572.x · Cited by 152
Signaling and stress: The redox landscape in NOS2 biology
Thomas, D. D., Heinecke, J. L., Ridnour, L. A., Cheng, R. Y., Kesarwala, A. H., Switzer, C. H., McVicar, D. W., Roberts, D. D., Glynn, S., Fukuto, J. M., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.002 · Cited by 150
Tuberculosis Is Associated with a Down-Modulatory Lung Immune Response That Impairs Th1-Type Immunity
de Almeida, A. S., Lago, P. M., Boéchat, N., Huard, R. C., Lazzarini, L. C. O., Santos, A. R., Nociari, M., Zhu, H., Perez‐Sweeney, B., Bang, H., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801212 · Cited by 151
Antinociceptive Effects of Interleukin-4, -10, and -13 on the Writhing Response in Mice and Zymosan-Induced Knee Joint Incapacitation in Rats
Vale, M. L., Marques, J. B., Moreira, C. A., Rocha, F. A. C., Ferreira, S. H., Poole, S., Cunha, F. Q., & Ribeiro, R. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.038703 · Cited by 152
Self-citation
Interleukin‐10 attenuates experimental fetal growth restriction and demise
Rivera, D. L., Olister, S. M., Liu, X., Thompson, J. H., Zhang, X. ‐., Pennline, K. J., Azuero, R., Clark, D. A., & Miller, M. J. S. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.2.189 · Cited by 141
The role of nitric oxide in multiple sclerosis
Parkinson, J. F., Mitrovic, B., & Merrill, J. E. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050102 · Cited by 139
Treatment of Experimental Viral Myocarditis With Interleukin-10
Nishio, R., Matsumori, A., Shioi, T., Ishida, H., & Sasayama, S. (1999) · Circulation · doi:10.1161/01.cir.100.10.1102 · Cited by 140
MACROPHAGE KILLING OF LEISHMANIA AMAZONENSIS AMASTIGOTES REQUIRES BOTH NITRIC OXIDE AND SUPEROXIDE
Mukbel, R., PATTEN, C., GIBSON, K., Ghosh, M., Petersen, C. A., & Jones, D. E. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.76.669 · Cited by 137
Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10
Tumpey, T. M., Cheng, H., Yan, X., Oakes, J. E., & Lausch, R. N. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.63.4.486 · Cited by 136
Shared signaling systems in myeloid cell-mediated muscle regeneration
Tidball, J. G., Dorshkind, K. A., & Wehling‐Henricks, M. (2014) · Development · doi:10.1242/dev.098285 · Cited by 151
Spinal cord injury-induced inflammation: A dual-edged sword
Bethea, J. R. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)28005-9 · Cited by 134
Induction of Cyclo-Oxygenase and Nitric Oxide Synthase in Inflammation
Appleton, I., Tomlinson, A., & Willoughby, D. A. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60274-4 · Cited by 133
Prevention of 1-palmitoyl lysophosphatidylcholine-induced inflammation by polyunsaturated acyl lysophosphatidylcholine
Hung, N. D., Sok, D., & Kim, M. R. (2012) · Inflammation Research · doi:10.1007/s00011-012-0434-x · Cited by 133
Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers*
Huhn, R. D., Radwanski, E., Gallo, J., Affrime, M. B., Sabo, R., Gonyo, G., Monge, A., & Cutler, D. L. (1997) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(97)90065-5 · Cited by 127
Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysacchride treatment in vivo in the rat
Liu, S. F., Adcock, I. M., Old, R. W., Barnes, P. J., & Evans, T. W. (1996) · Critical Care Medicine · doi:10.1097/00003246-199607000-00026 · Cited by 130
Role of Interleukin-10 in the Lung Response to Silica in Mice
Huaux, F., Louahed, J., Hudspith, B. N., Meredith, C., Delos, M., Renauld, J., & Lison, D. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.18.1.2911 · Cited by 126
Inducible Nitric Oxide Synthase and Nitrotyrosine Are Found in Monocytes/Macrophages and/or Astrocytes in Acute, but Not in Chronic, Multiple Sclerosis
Oleszak, E. L., Zaczyńska, E., Bhattacharjee, M. B., Butunoi, C., Legido, A., & Katsetos, C. D. (1998) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.5.4.438-445.1998 · Cited by 125
Differential regulation of IFN‐γ, IL‐10 and inducible nitric oxide synthase in human T cells by cyclic AMP‐dependent signal transduction pathway
Benbernou, N., Esnault, S. J., Shin, H. C. K., Fekkar, H., & Guenounou, M. (1997) · Immunology · doi:10.1046/j.1365-2567.1997.00260.x · Cited by 124
Impaired neuroglial activation in interleukin‐6 deficient mice
Klein, M., Möller, J., Jones, L., Bluethmann, H., Kreutzberg, G., & Raivich, G. (1997) · Glia · doi:10.1002/(sici)1098-1136(199703)19:3 · Cited by 298
Cytokines Regulate L‐Arginine‐Dependent Cyclic GMP Production in Rat Glial Cells
Simmons, M. L., & Murphy, S. P. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00934.x · Cited by 122
Blood interleukin 10 levels parallel the severity of septic shock
Friedman, G., Jankowski, S., Marchant, A., Goldman, M., Kahn, R. J., & Vincent, J. (1997) · Journal of Critical Care · doi:10.1016/s0883-9441(97)90030-7 · Cited by 120
Cell markers and determinants in fish immunology
Randelli, E., Buonocore, F., & Scapigliati, G. (2008) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2008.03.019 · Cited by 123
Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers
Gotlieb, W. H., Abrams, J. S., Watson, J. M., Velu, T. J., Berek, J. S., & Martı́nez-Maza, O. (1992) · Cytokine · doi:10.1016/1043-4666(92)90082-3 · Cited by 119
Interleukin-10 Inhibits Intimal Hyperplasia After Angioplasty or Stent Implantation in Hypercholesterolemic Rabbits
Feldman, L. J., Aguirre, L., Ziol, M., Bridou, J.-P., Névo, N., Michel, J., & Steg, P. G. (2000) · Circulation · doi:10.1161/01.cir.101.8.908 · Cited by 120
Assembly and regulation of NADPH oxidase and nitric oxide synthase
Bastian, N. R., & Hibbs, J. B. (1994) · Current Opinion in Immunology · doi:10.1016/0952-7915(94)90044-2 · Cited by 120
Immune Mechanisms of Protection
Chan, J., & Kaufmann, S. H. E. (2014) · ASM Press eBooks · doi:10.1128/9781555818357.ch24 · Cited by 122
Nitric Oxide-Induced Nitrative Stress Involved in Microbial Pathogenesis
Zaki, M. H., Akuta, T., & Akaike, T. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05004x · Cited by 120
Elevation of serum levels of the anti-inflammatory cytokine interleukin-10 and decreased risk of coronary events in patients with unstable angina
Anguera, I., Miranda‐Guardiola, F., Bosch, X., Filella, X., Sitges, M., Marı́n, J. L., Betriu, A., & Sanz, G. (2002) · American Heart Journal · doi:10.1067/mhj.2002.124831 · Cited by 118
Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells
Zhou, X., Meyer, C. U., Schmidtke, P., & Zepp, F. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02359-2 · Cited by 117
Interleukin-10 potential benefits and possible risks in clinical infectious diseases
Opal, S. M., Wherry, J. C., & Grint, P. (1998) · Clinical Infectious Diseases · doi:10.1086/515032 · Cited by 114
Resistance of filarial nematode parasites to oxidative stress
Selkirk, M. E., Smith, V. P., Thomas, G., & Gounaris, K. (1998) · International Journal for Parasitology · doi:10.1016/s0020-7519(98)00107-6 · Cited by 113
Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production
Baseler, W. A., Davies, L. C., Quigley, L., Ridnour, L. A., Weiss, J. M., Hussain, S. P., Wink, D. A., & McVicar, D. W. (2016) · Redox Biology · doi:10.1016/j.redox.2016.09.005 · Cited by 115
Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase
Szabó, C., & Thiemermann, C. (1995) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61083-2 · Cited by 111
T Lymphocytes in Atherosclerosis
Daugherty, A., & Rateri, D. L. (2002) · Circulation Research · doi:10.1161/01.res.0000021397.28936.f9 · Cited by 111
Pathophysiology and Therapeutic Approaches for Spinal Cord Injury
Lima, R., Monteiro, A., Salgado, A. J., Monteiro, S., & Silva, N. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213833 · Cited by 122
Multifunctional role of nitric oxide in inflammation
Laskin, J. D., Heck, D. E., & Laskin, D. L. (1994) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(94)90105-8 · Cited by 106
Listeria meningitis: identification of a cerebrospinal fluid inhibitor of macrophage listericidal function as interleukin 10.
Frei, K., Nadal, D., Pfister, H., & Fontana, A. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.4.1255 · Cited by 107
Interleukin‐6 functions in autoimmune encephalomyelitis: a study in gene‐targeted mice
Mendel, I., Katz, A., Kozak, N., Ben‐Nun, A., & Revel, M. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199805)28:05 · Cited by 161
Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: its underlying mechanism in comparison with interleukin-4
Niiro, H., Otsuka, T., Tanabe, T., Hara, S., Kuga, S., Nemoto, Y., Tanaka, Y., Nakashima, H., Kitajima, S., & Abe, M. (1995) · Blood · doi:10.1182/blood.v85.12.3736.bloodjournal85123736 · Cited by 103
Beneficial actions of melatonin in the management of viral infections: a new use for this “molecular handyman”?
Boga, J. A., Coto‐Montes, A. M., Rosales‐Corral, S., Tan, D. X., & Reiter, R. J. (2012) · Reviews in Medical Virology · doi:10.1002/rmv.1714 · Cited by 100
Anti-inflammatory effects of annexin-1: stimulation of IL-10 release and inhibition of nitric oxide synthesis
Ferlazzo, V., D’Agostino, P., Milano, S., Caruso, R., Feo, S., Cillari, E., & Parente, L. (2003) · International Immunopharmacology · doi:10.1016/s1567-5769(03)00133-4 · Cited by 97
Pro-Opiomelanocortin-Derived Peptides, Cytokines, and Nitric Oxide in Immune Responses and Stress: An Evolutionary Approach
Ottaviani, E., Franchini, A., & FranceschiR, C. (1997) · International review of cytology · doi:10.1016/s0074-7696(08)61621-6 · Cited by 93

Authors: Cunha, F. Q., Mohcada, S., & Liew, F. Y.
Affiliations: Wellcome Trust (GB)
University of Glasgow (GB)
Corresponding author: Liew, F.Y.
ORCID: Cunha, F.Q.
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 1992-02
Volume: 182
Issue: 3
Pages: 1155-1159
ISSN: 0006-291X (ISSN-L)
DOI: 10.1016/0006-291x(92)91852-h
OpenAlex: W2038992843
Cited by: 383
References: 23
Citations by year: 2026: 4 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 5
FWCI: 11.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical and Biophysical Research Communications (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: IL-10, interferon-gamma, nitric oxide synthase, nitric oxide, macrophages, J774 cells, lipopolysaccharide, Th1/Th2 balance, cytokine antagonism, macrophage activation
MeSH terms: Amino Acid Oxidoreductases, Animals, Cell Line, Enzyme Induction, Interferon-gamma, Kinetics, Macrophages, Nitric Oxide, Recombinant Proteins, Interleukin-10, Nitric Oxide Synthase, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks