Post-transcriptional regulation of insulin-like growth factor binding protein-2 mRNA in diabetic rat liver.
Abstract
IGFBP-1 and IGFBP-2 mRNAs are increased in the livers of streptozotocin-diabetic rats. A corresponding increase is observed in transcription of the IGFBP-1 but not the IGFBP-2 gene, indicating that the increase in steady-state levels of IGFBP-2 mRNA is a post-transcriptional effect. IGFBP-1 and IGFBP-2 mRNAs also differ in the rapidity of their response to insulin treatment: hepatic IGFBP-1 mRNA is normalized within 1 h, IGFBP-2 mRNA decreases more slowly. These differences suggest that IGFBP-2 may provide more chronic adaptation to metabolic change than IGFBP-1.
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Hepatic Igfbp-2 expression is tonically inhibited by insulin and dramatically up-regulated by insulin deficiency.
“hepatic Igfbp-2 expression is tonically inhibited by insulin and hence dramatically up-regulated by insulin deficiency (50 -52).”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [51]
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Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works
“Since insulin treatment of diabetic rodents lowers both HGP and Igfbp2 gene expression (26, 138, 194), the notion that IGFBP2 plays a major role in leptin-mediated inhibition of HGP seems counterintuitive.”
BackgroundGerman, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2011) · Endocrinology · doi:10.1210/en.2010-0890 · Cited by 169 · see citing works
- Authors
- Ooi, G. T., Y.-H. Tseng, L., & Rechler, M. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ooi, Guck T.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1992-12
- Volume
- 189
- Issue
- 2
- Pages
- 1031-1037
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2002789373
- Cited by
- 21
- References
- 23
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- IGFBP-2, IGFBP-1, post-transcriptional regulation, mRNA stability, diabetic liver, streptozotocin-induced diabetes, insulin therapy, hepatic gene expression
- MeSH terms
- Animals, Carrier Proteins, Cell Nucleus, Diabetes Mellitus, Experimental, Insulin, Insulin, Isophane, Kinetics, Liver, Male, RNA Processing, Post-Transcriptional, RNA, Messenger, Somatomedins, Transcription, Genetic, Blotting, Northern, Rats, Sprague-Dawley, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 2, Rats
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