The DOI matches its Crossref record; the references it cites are not checked yet.
Obsessive-compulsive disorder: Is there a frontal lobe dysfunction?
Abstract
Obsessive-compulsive disorder has recently been found to be associated with various biochemical markers; this has revived interest in its biological basis. Most of the work to date has concentrated on the neurotransmitters involved. In this presentation, evidence from electrophysiological, neuropsychological, scan, lesion, and psychosurgical studies are integrated to focus on a possible frontal dysfunction in this disorder.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These findings suggest an array of neural differences between OCD and HC groups, which are likely to reflect alterations in executive functions such as attentional processes, conflict monitoring and response inhibition, perhaps produced by frontal dysfunction, which is a known finding in OCD (Khanna, 1988; Schmidtke, Schorb, Winkelmann, & Hohagen, 1998).”
From Obsessive–compulsive disorder (OCD) is associated with increased engagement of frontal brain regions across multiple event-related potentials (2023) · cites this paper as Khanna, 1988
In the citing paper
“which is a known finding in OCD (Khanna, 1988; Schmidtke, Schorb, Winkelmann, & Hohagen, 1998).”
From Obsessive–compulsive disorder (OCD) is associated with increased engagement of frontal brain regions across multiple event-related potentials (2023) · cites this paper as Khanna, 1988
Citations
The citation lists are queued
They are fetched later and appear here then.
References 83 · Cited by 64
Research works printed but not linked: 69
- Ali-Cherif, 1984, Troibles du comportement et de la activite mentale apres intoxicaton oxy-carbonee, Rev Neurol, 140, 401
- Baxter, 1985, Cerebral metabolic rates for glucose in mood disorders: studies with positron emission tomography and fluorodeoxyglucose F18, Arch Gen Psychiatry, 42, 441, 10.1001/archpsyc.1985.01790280019002 · DOI
- Baxter, 1987, Local cerebral metabolic rates in obsessive-compulsive disorder, Arch Gen Psychiatry, 44, 211, 10.1001/archpsyc.1987.01800150017003 · DOI
- Beech, 1983, Further observations of evoked potentials in obsessional patients, Br J Psychiatry, 142, 605, 10.1192/bjp.142.6.605 · DOI
- Behar, 1984, Computerised tomography and neuropsychological test measures in adolescents with obsessive compulsive disorder, Am J Psychiatry, 141, 363, 10.1176/ajp.141.3.363 · DOI
- Bender, 1935, Anatamopathological data on personality, Am J Psychiatry, 92, 325, 10.1176/ajp.92.2.325 · DOI
- Bernstein, 1975, Lobotomy in private practice, Arch Gen Psychiatry, 32, 1041, 10.1001/archpsyc.1975.01760260105009 · DOI
- Bingley, 1978, EEG studies on patients with chronic obsessive compulsive neurosis before and after psychosurgery, Electroencephal Clin Neurophysiol, 53, 435
- Brickner, 1940, A human cortical area producing repetitive phenomena when stimulated, J Neurophysiol, 3, 128, 10.1152/jn.1940.3.2.128 · DOI
- Bridges, 1973, A review of patients with obsessional symptoms treated with psychosurgery, 96
- Bridges, 1973, A comparative review of patients with obsessional neurosis and with depression treated with psychosurgery, Br J Psychiatry, 123, 663, 10.1192/bjp.123.6.663 · DOI
- Brown, 1968, Selective anterior cingulotomy: A psychosurgical evaluation, J Neurosurg, 29, 513, 10.3171/jns.1968.29.5.0513 · DOI · Paper page
- Cieselki, 1981, Some electrophysiological observations in obsessional states, Br J Psychiatry, 138, 479, 10.1192/bjp.138.6.479 · DOI
- Cummings, 1985, Gilles de la Tourette syndrome and the neurological basis of obsessions and compulsions, Biol Psychiatry, 20, 1117, 10.1016/0006-3223(85)90011-3 · DOI
- Deecke, 1978, An electrical sign of participation of the mesial “supplementary” motor cortex in human voluntary finger movement, Brain Res, 159, 473, 10.1016/0006-8993(78)90561-9 · DOI
- Devenport, 1981, Reward induced stereotype: Modulation by the hippocampus, Science, 212, 1288, 10.1126/science.7195073 · DOI
- Donnely, 1972, Comparison of temporal lobe epileptics and affective disorders on the Halstead-Reitan Test Battery, J Clin Psychol, 28, 61, 10.1002/1097-4679(197201)28:1<61::AID-JCLP2270280119>3.0.CO;2-R · DOI
- Epstein, 1971, Sleep and dream studies in obsessional neurosis with particular reference to epileptic states, Biol Psychiatry, 3, 149
- Flor-Henry, 1975, Psychiatrie surgery 1935–1973: Evolution and current perspectives, Can Psychiatry Assoc J, 20, 157, 10.1177/070674377502000210 · DOI
- Flor-Henry, 1979, Neuropsychological and power spectral EEG investigations of the obsessive compulsive syndrome, Biol Psychiatry, 14, 119
- Fodstad, 1982, Treatment of chronic obsessive compulsive states with stereotactic anterior capsulotomy or cingulotomy, Acta Neurochir, 62, 1, 10.1007/BF01402207 · DOI
- Gibson, 1960, A clinical EEG study on a case of obsessional neurosis, Electroencephalogr Clin Neurophysiol, 12, 198, 10.1016/0013-4694(60)90076-6 · DOI
- Goktepe, 1975, A further review of the results of stereotactic subcaudate tractotomy, Br J Psychiatry, 126, 270, 10.1192/bjp.126.3.270 · DOI
- Hassler, 1980, Brain mechanisms of intention and attention with introductory remarks on other voluntary processes, Prog Brain Res, 54, 585, 10.1016/S0079-6123(08)61680-5 · DOI
- Hassler, 1967, Stereotaxic treatment of compulsions and obsessive symptoms, Confin Neurol, 29, 153, 10.1159/000103695 · DOI
- Hassler, 1970, Treatment stereotaxique des tics et cris inarticules ou coprolaliques consideres comme phenomene d'obsession motrice on cours de la maladie de Gilles de la Tourette, Rev Neurol, 123, 89
- Hohman, 1951, Preliminary report on the follow-up of prefrontal lobotomies performed by the Duke neurosurgical staff, NC Med J, 12, 529
- Ingram, 1960, The electroencephalogram, obsessional illness and obsessional personality, J Mental Sci, 106, 686, 10.1192/bjp.106.443.686 · DOI
- Insel, 1983, Neurological and neuropsychological studies of patients with obsessive-compulsive disorder, Biol Psychiatry, 18, 741
- Jenike, 1983, Obsessive compulsive disorder, Compr Psychiatry, 24, 99, 10.1016/0010-440X(83)90098-6 · DOI
- Jenike, 1984, The electroencephalogram in obsessive compulsive disorder, J Clin Psychiatry, 45, 122
- Khanna, 1985, Post-traumatic obsessive compulsive disorder—A single case report, Ind. J. Psychiatry, 27, 337
- Khanna, 1987, Obsessive compulsive disorder: Is it a problem of complex motor programming?, Ind J Psychiatry, 29, 41
- Khanna, 1988, Middle latency evoked potentials in obsessive compulsive disorder, Biol Psychiatry
- Khanna, 1988, Habituation of evoked potentials in obsessive compulsive disorder and melancholic depression, Int J Psychophysiology
- Khanna, 1988, Contingent negative variation in obsessive compulsive disorder, NIMHANS J
- Klonoff, 1970, Neuropsychological patterns in chronic schizophrenia, J Nerv Ment Dis, 150, 291, 10.1097/00005053-197004000-00004 · DOI
- Knight, 1955, Orbital leucotomy—A review of 52 cases, Lancet, 1, 981, 10.1016/S0140-6736(55)91963-2 · DOI
- Laplane, 1981, Comportement compulsif d 'allure Obsessionelle par necrose circonscrite bilaterale pallidostriatale, Rev Neurol, 137, 269
- Latinen, 1973, Electrophysiological and psychological studies on the function of the rostral cingulum and the knee of the corpus callosum in man, Psychiatr Fenn, 5, 249
- MacLean, 1985, Brain evolution relating to family, play and the separation call, Arch Gen Psychiatry, 42, 405, 10.1001/archpsyc.1985.01790270095011 · DOI
- McCallum, 1968, The effects of attention and distraction on the contingent negative variation in neurotic and normal subjects, Electroencephalogr Clin Neurophysiol, 25, 319, 10.1016/0013-4694(68)90172-7 · DOI
- Mettler, 1955, Perceptual capacity, functions of the corpus striatum and schizophrenia, Psychiatr Q, 29, 89, 10.1007/BF01567442 · DOI
- Minski, 1933, Mental symptoms associated with 58 cases of cerebral tumors, J Neurol Psychopathol, 13, 330, 10.1136/jnnp.s1-13.52.330 · DOI
- Mitchell-Heggs, 1976, Stereotactic limbic leucotomy: A follow up at 16 months, Br J Psychiatry, 128, 226, 10.1192/bjp.128.3.226 · DOI
- Moore, 1952, Prefrontal leucotomy: A follow up study of 71 cases, J Irish Med Assoc, 30, 120
- Morris, 1982, Place navigation is impaired in rats with hippocampal lesions, Nature, 297, 681, 10.1038/297681a0 · DOI · Paper page
- Muller, 1985, Prefrontal cortex dysfunction as a common factor in psychosis, Acta Psychiatr Scand, 71, 431, 10.1111/j.1600-0447.1985.tb05055.x · DOI
- Paillas, 1971, Reflections sur la psychochirugie dans le traitement des nevroses obsessionnelles, Semaines Hop Paris, 15, 944
- Paunovic, 1984, Obsessional syndrome with organic brain disease, Ann Med Psychol, 142, 379
- Pippard, 1955, Rostral leucotomy: A report of 240 cases personally followed up after 1 12 to 5 years, J Mental Sci, 101, 756, 10.1192/bjp.101.425.756 · DOI
- Pitman, 1982, Neurological etiology of obsessive compulsive disorder, Am J Psychiatry, 139, 139, 10.1176/ajp.139.1.139-b · DOI
- Pulst, 1983, Carbon monoxide poisoning with features of Gilles de la Tourette syndrome, Arch Neurol, 10, 443, 10.1001/archneur.1983.04050070073019 · DOI
- Rockwell, 1947, The electroencephalogram and personality organisation in the obsessive compulsive reaction, Arch Neurol Psychiatry, 57, 71, 10.1001/archneurpsyc.1947.02300240087004 · DOI
- Sartory, 1984, Contingent negative variation in obsessional patienls, Biol Psychiatry, 18, 253, 10.1016/0301-0511(84)90057-7 · DOI
- Schilder, 1938, The organic background of obsessions and compulsions, Am J Psychiatry, 94, 1397, 10.1176/ajp.94.6.1397 · DOI
- Schneider, 1984, Basal ganglia role in behaviours: Importance of sensory gating and its relevance to psychiatry, Biol Psychiatry, 19, 1693
- Serafitinides, 1984, EEG lateral asymmetrices in psychiatric disorders, Biol Psychol, 19, 237, 10.1016/0301-0511(84)90040-1 · DOI
- Shagass, 1984, Evoked potentials in obsessive compulsive disorder, Adv Biol Psychiatry, 15, 69, 10.1159/000410504 · DOI
- Shagass, 1984, Distinctive somalosensory evoked potential features in obsessive compulsive disorder, Biol Psychiatry, 19, 1507
- Skinner, 1976, Regulation of slow potential shifts in nucleus reticularis thalami by the mesencephalic reticular formation and the fronlal granular cortex, Electroencephalogr Clin Neurophysiol, 40, 288, 10.1016/0013-4694(76)90152-8 · DOI
- Spiegel, 1953, Thalamolomy and hypolhalamolomy for the trealmenl of psychosis, Res Publ Assoc Nerv Ment Dis, 31, 379
- Strom-Olsen, 1971, Bifrontal stereotactic traclomy, Br J Psychiatry, 118, 141, 10.1192/bjp.118.543.141 · DOI
- Sykes, 1964, Restricted orbital undercutting, Br J Psychiatry, 110, 609, 10.1192/bjp.110.468.609 · DOI
- Timsil-Berthier, 1973, Slow potential changes in psychiatry, Electroencephalogr Clin Neurophysiol, 28, 41
- Turner, 1985, Biological factors in obsessive compulsive disorder, Psychol Bull, 97, 430, 10.1037/0033-2909.97.3.430 · DOI
- Whitty, 1952, Anterior cingulectomy in the Ireatment of mental disease, Lancet, 1, 465
- Yarvura-Tobias, 1977, l-tryplophan in obsessive compulsive disorder, Am J Psychiatry, 134, 1298, 10.1176/ajp.134.11.1298 · DOI
- Zohar, 1987, Obsessive compulsive disorder: Psychobiological approaches to diagnosis, treatment and pathophysiology, Biol Psychiatry, 22, 667, 10.1016/0006-3223(87)90199-5 · DOI
Metadata
- Authors
- Khanna, S.
- Affiliations
- National Institute of Mental Health and Neurosciences (IN)
- Corresponding author
- Khanna, Sumant
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1988-09
- Volume
- 24
- Issue
- 5
- Pages
- 602-613
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2064498482
- Cited by
- 64
- References
- 83
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, frontal lobe dysfunction, frontal lobe, neurotransmitters, biochemical markers, neuropsychological assessment, neuroimaging, brain lesions, psychosurgery, electrophysiology
- MeSH terms
- Brain Mapping, Frontal Lobe, Humans, Neuropsychological Tests, Obsessive-Compulsive Disorder
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Obsessive-compulsive disorder: Is there a frontal lobe dysfunction? https://app.cochat.ai/papers/10.1016/0006-3223(88)90171-0
- The paper
- Khanna, S. (1988). Obsessive-compulsive disorder: Is there a frontal lobe dysfunction? Biological Psychiatry. https://doi.org/10.1016/0006-3223(88)90171-0
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.