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Cited by 104Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Excitatory effect of dopamine on oxytocin and vasopressin reflex releases in the rat

Moos, Françoise, Richard, Philippe·1982·Brain Research
DOI 10.1016/0006-8993(82)91061-7
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Abstract

The involvement of dopamine in the release of oxytocin and vasopressin was investigated in lactating rats during suckling or after changes in plasma osmolality. The effects of intraventricular injections of dopamine, agonists and antagonists, were tested on electrical unit activity of oxytocinergic or vasopressinergic cells in the paraventricular nucleus, on intramammary pressure (index of oxytocin release) and diuresis (index of vasopressin release). In urethane-anaesthetized lactating suckled rats, dopamine (1 microgram), apomorphine (2.5 and 5 micrograms) facilitated the established milk-ejection reflex, increasing the frequency and the amplitude of neurosecretory bursts of oxytocinergic cells. They also triggered the reflex in lactating rats without milk-ejections during suckling. The small doses injected were in no way such as to induce an acceleration in firing rate of oxytocinergic cells or an increase in mammary pressure. In alcohol-loaded rats, during water diuresis, dopamine (2 micrograms) and apomorphine (5 micrograms) activated the depressed vasopressinergic cells and inhibited diuresis. These facilitatory effects were progressive, reaching a maximum 10-15 min after injection. Haloperidol (5 micrograms) and alpha-flupentixol (10 micrograms) had an inhibitory effect on both types of neurosecretory cells in urethane-anaesthetized rats. They prevented the reflex activation of oxytocinergic cells induced by suckling and of vasopressinergic cells after a hyperosmotic stimulus (1 ml i.p 9% NaCl solution). These inhibitory effects were not of the "all-or-none' type. So, we can postulate that dopamine regulates the reflex release of oxytocin and vasopressin in the hypothalamus. On the one hand, dopamine permits and controls the periodic activation of oxytocinergic cells as long as the mothers are being suckled. On the other hand, it modulates the activity of vasopressinergic cells whenever the plasma osmolality changes.

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Citations

Cites

Research works printed but not linked: 3

  1. Clarke, 1975, Evidence for a dopaminergic component in the milk-ejection reflex of the rat, J. Endocr., 67, 32
  2. Guerné, 1978, L'importance relative de la noradrénaline (NA) et de la dopamine (DA) dans la libération des hormones posthypophysaires, C. R. Acad Sci. (Paris), 286, 1609
  3. Moos, 1980, Double controle noradrénergique de la libération d'ocytocine pendant le réflexe d'éjection du lait chez la Ratte, C. R. Acad. Sci. (Paris), 290, 1261

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Metadata

Authors
Moos, F., & Richard, P.
Affiliations
Centre National de la Recherche Scientifique (FR)
ORCID
Richard, Philippe
Venue
Brain Research
Publisher
Elsevier BV
Published
1982-06
Volume
241
Issue
2
Pages
249-260
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(82)91061-7
OpenAlex
W2049329047
Cited by
104
References
43
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
10.08
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
dopamine, oxytocin, vasopressin, milk ejection reflex, lactation, suckling, plasma osmolality, paraventricular nucleus, apomorphine, haloperidol, diuresis, hypothalamus, neurosecretion
MeSH terms
Animals, Apomorphine, Dopamine, Electric Stimulation, Female, Haloperidol, Lactation, Milk Ejection, Osmolar Concentration, Oxytocin, Pituitary Gland, Anterior, Pregnancy, Rats, Inbred Strains, Reflex, Vasopressins, Rats

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