Cited by 378Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

Oxytocin, motherhood and bonding

Kendrick, Keith. M.·2000·Experimental Physiology

Abstract

Release of the peptide hormone oxytocin in the brain has been shown to influence both maternal, sexual and social bonding behaviours although there are a number of species differences. This review summarizes findings on the distributions of oxytocin and oxytocin receptors in the brain, together with factors governing their expression, release of the peptide in the brain and its behavioural actions. A model of how oxytocin may act to alter maternal and socio‐sexual behaviours is proposed which initially involves activation of oxytocin neurones in a single brain site, the paraventricular nucleus of the hypothalamus (PVN), following vaginal and cervical stimulation. This causes a co‐ordinated release of the peptide in the PVN and its terminal projection regions for up to 1 h and this promotes different behavioural components, primarily through modulation of classical transmitter systems.

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Crossref · 10.1111/j.1469-445x.2000.tb00014.x

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99 of 99 references verified0 citation errors · 0 not checkable

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  • In humans, OT plays key roles in social bonding in general, as well as specific aspects of maternal brain function, including vaginal delivery, breastfeeding, and parental sensitivity.

    “In humans, OT plays key roles in social bonding in general (29), as well as specific aspects of maternal brain function (30), including: (i) vaginal delivery (31); (ii) breastfeeding (32); and (iii) parental sensitivity (33–36).”

    From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [31]

  • OXT plays a critical role in the facilitation of social bonding and prosocial behavior toward a social partner.

    “Oxytocin (OXT), a neuromodulatory nonapeptide, plays a critical role in the facilitation of social bonding and prosocial behavior toward a social partner (Feldman, 2012).”

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Authors
Kendrick, K. M.
Affiliations
Babraham Institute (GB)
Corresponding author
Kendrick, Keith. M.
Venue
Experimental Physiology
Publisher
Wiley
Published
2000-03
Volume
85
Issue
s1
Pages
111S-124S
ISSN
  • 0958-0670 (ISSN-L)
  • 1469-445X
OpenAlex
W2069334714
Cited by
378
References
99
Citations by year
2026: 2 · 2025: 12 · 2024: 8 · 2023: 24 · 2022: 11 · 2021: 23 · 2020: 43 · 2019: 16 · 2018: 8 · 2017: 14 · 2016: 24 · 2015: 20 · 2014: 14 · 2013: 19 · 2012: 10
FWCI
2.60
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
oxytocin, maternal behavior, social bonding, sexual behavior, oxytocin receptor, paraventricular nucleus, neurotransmitter systems, species differences
MeSH terms
Animals, Brain Chemistry, Maternal Behavior, Object Attachment, Oxytocin

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