Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex
Abstract
Levels of serotonin type-2 receptors and choline acetyltransferase (ChAT) were measured in various rat brain regions following unilateral lesions of the nucleus basalis magnocellularis (nBM). As expected, lesions of the nBM markedly decrease cortical ChAT activity. Moreover, [3H]ketanserin (serotonin type-2) binding is significantly decreased in lamina IV of the anterior and middle cortex on the lesioned vs control side. [3H]ketanserin binding in the striatum is not affected by lesions of the nBM. Autoradiograms of [3H]ketanserin binding in lesioned animals show similar results. This suggests that at least a certain proportion of serotonin type-2 receptor binding sites are located on cholinergic terminals in lamina IV of the rat cortex. Therefore, further investigations on cholinergic-serotonergic interactions in the cortex and their possible involvement in senile dementia of the Alzheimer's type appear to be highly relevant.
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In rodents, the 5-HT2A receptor expression pattern has been confirmed using immunohistochemistry, light and electron microscope immunocytochemistry, in situ hybridization, receptor autoradiography, and transgenic mice expressing EGFP under control of the 5-HT2A receptor promoter.
“In rodents, this expression pattern has been confirmed using immunohistochemistry (203–206), light and electron microscope immunocytochemistry (203), in situ hybridization (207, 208), receptor autoradiography (209), and transgenic mice expressing EGFP under control of the 5-HT2A receptor promoter (210).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [209]
Cites
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works
Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962 · see citing works
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Winstanley, C. A., Chudasama, Y., Dalley, J. W., Theobald, D. E. H., Glennon, J. C., & Robbins, T. W. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1398-x · Cited by 234 · see citing works
Psychedelics and Other Psychoplastogens for Treating Mental Illness.
Vargas, M. V., Meyer, R., Avanes, A. A., Rus, M., & Olson, D. E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.727117 · Cited by 166 · see citing works
Lidow, M. S., Goldman‐Rakic, P. S., Gallager, D. W., & Rakic, P. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902800104 · Cited by 77 · see citing works
- Authors
- Quirion, R., Richard, J., & Dam, T. V.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Quirion, R.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1985-05
- Volume
- 333
- Issue
- 2
- Pages
- 345-349
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2087310502
- Cited by
- 88
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2017: 1 · 2015: 2 · 2013: 2
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- cholinergic nerve terminals, nucleus basalis magnocellularis, choline acetyltransferase, ketanserin binding, cholinergic-serotonergic interaction, Alzheimer's disease, senile dementia, striatum, rat cortex
- MeSH terms
- Alzheimer Disease, Animals, Basal Ganglia, Cerebral Cortex, Cholinergic Fibers, Humans, Male, Neural Pathways, Rats, Inbred Strains, Receptors, Serotonin, Substantia Innominata, Rats
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