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Cited by 77Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Quantitative autoradiographic mapping of serotonin 5‐HT1 and 5‐HT2 receptors and uptake sites in the neocortex of the rhesus monkey

Lidow, Michael S., Goldman‐Rakic, Patricia S., Gallager, Dorothy W., Rakic, Pasko·1989·Journal of Comparative Neurology
DOI 10.1002/cne.902800104
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Abstract

The in vitro autoradiographic technique was used to characterize the distribution of serotonin 5‐HT 1 and 5‐HT 2 receptors and uptake sites in 11 cortical areas of frontal, parietal, and occipital lobes in the rhesus monkey; 5‐HT 1 receptors were labeled with [3 H]5‐HT; 5‐HT 2 receptors were labeled with [3 H]ketanserin; and 5‐HT uptake sites were labeled with [3 H]citalopram. Five‐HT 1 and 5‐HT 2 receptors and 5‐HT uptake sites were found in every cortical area examined with the absolute concentration of 5‐HT 1 receptors higher than that of 5‐HT 2 receptors in all areas. In eight regions of prefrontal and parietal as well as in prestriate cortex, 5‐HT 1 and 5‐HT 2 receptors had complementary distribution profiles: 5‐HT 1 receptors were concentrated in layers I and II and the upper strata of layer III, while 5‐HT 2 receptors had their highest concentration throughout layers III and IV. Only the primary motor and visual cortex had receptor distributions different from that described above. Thus, in the primary visual cortex, both 5‐HT 1 and 5‐HT 2 receptors were found in high concentration in sublayer IVcß, though the density of 5‐HT 1 receptor was also high in other subdivisions of layer IV and in layers III, V, and VI. In the primary motor cortex, both receptor subtypes were concentrated in layers I and II and the upper strata of layer III. The pattern of distribution of serotonin uptake sites did not match the patterns of distribution of either 5‐HT 1 or 5‐HT 2 receptors alone; rather it approximated the combined patterns of distribution of both receptor subtypes. The complementary patterns of distribution of 5‐HT 1 and 5‐HT 2 receptors in most areas of the monkey cerebral cortex suggest that these two receptor subtypes may make differential contributions to cortical functions.

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  • Major neurotransmitter receptors are initially overproduced in all eight primate prefrontal regions examined.

    “It was furthermore discovered that major neurotransmitter receptors are also initially overproduced in all eight primate prefrontal regions examined [104, 105].”

    From Development of prefrontal cortex (2022) · cites this paper as [105]

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Related

Authors
Lidow, M. S., Goldman‐Rakic, P. S., Gallager, D. W., & Rakic, P.
Affiliations
Yale University (US)
ORCID
Rakic, Pasko
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1989-02
Volume
280
Issue
1
Pages
27-42
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902800104
OpenAlex
W2062883936
Cited by
77
References
83
Citations by year
2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
1.51
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5729 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Johns Hopkins University
  • U.S. Public Health Service
  • National Eye Institute (EY02593)
  • National Institute of Neurological Disorders and Stroke (NS-22807, NS-07224)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
5-HT2 receptor, serotonin uptake sites, neocortex, rhesus monkeys, receptor distribution, cortical layers, primary motor cortex, primary visual cortex, autoradiography
MeSH terms
Animals, Autoradiography, Cerebral Cortex, Female, Ketanserin, Macaca, Macaca mulatta, Male, Receptors, Serotonin, Citalopram

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