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Cited by 349

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis

Lerma, J., Herranz, A.S., Herreras, O., Abraira, V., del Rio, R. Martin·1986·Brain Research
DOI 10.1016/0006-8993(86)91230-8
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Abstract

Extracellular (EC) concentrations of amino acids were determined in the rat dentate gyrus by means of non-linear regression analysis of 'in vivo' brain dialysis data, considering a simple model of diffusion through a dialysis membrane. The apparent diffusion constants (K) of several amino acids were also calculated in the 'in vivo' situation. While putative amino acid neurotransmitters (glutamate, aspartate and gamma-aminobutyric acid (GABA) were present in the EC fluid at the low micromolar range (0.8-2.9 microM), glutamine was by far the most prominent (193.4 microM). The values of intra/extracellular concentration ratios formed 3 groups: high (greater than 2000) for putative neurotransmitters; low (less than 100) for serine, glutamine, arginine and alpha-alanine; and intermediate (about 400) for taurine. The 'in vivo' calculated K values proved useful for estimation of both basal and changing EC concentrations of amino acids in relatively brief perfusions. These data were evaluated in terms of the functional significance of absolute EC concentrations and tissue-EC fluid ratios. Present findings indicate the simultaneous existence of both an inhibitory and an excitatory tonus as well as the utility of high intra/extracellular concentration ratios in determination of the possible neurotransmitter role of specific amino acids.

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Crossref · 10.1016/0006-8993(86)91230-8

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Citations

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Research works printed but not linked: 1

  1. Lerma, 1982, Chronic dialytrode perfusion: amino acid profiles of brain structures, Neuroscience, S131

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Metadata

Authors
Lerma, J., Herranz, A. S., Herreras, O., Abraira, V., & del Rio, R. M.
Venue
Brain Research
Publisher
Elsevier BV
Published
1986-10
Volume
384
Issue
1
Pages
145-155
ISSN
0006-8993
DOI
10.1016/0006-8993(86)91230-8
Cited by
349
References
40
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. https://app.cochat.ai/papers/10.1016/0006-8993(86)91230-8
The paper
Lerma, J., Herranz, A. S., Herreras, O., Abraira, V., & del Rio, R. M. (1986). In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Research. https://doi.org/10.1016/0006-8993(86)91230-8

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.