Acetylcholine in the interpeduncular nucleus of the rat: normal distribution and effects of deafferentation

Eckenrode, T.C.; Barr, G.A.; Battisti, W.P.; Murray, M.

doi:10.1016/0006-8993(87)90095-3

Cited by 64Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Acetylcholine in the interpeduncular nucleus of the rat: normal distribution and effects of deafferentation

Eckenrode, T.C., Barr, G.A., Battisti, W.P., Murray, M.·1987·Brain Research

DOI 10.1016/0006-8993(87)90095-3

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Abstract

We studied the cholinergic projection to the interpeduncular nucleus (IPN) by examining localization of choline acetyltransferase (ChAT) in the habenula, fasciculus retroflexus (FR) and among the subnuclei of the IPN of the rat, using and antibody raised against ChAT. ChAT-containing neurons were present in the ventral portion of the medial habenula, ChAT-stained axons were present in the FR and ChAT-stained axons and terminals were present in the rostral, central and intermediate subnuclei of the IPN. No ChAT staining was seen in the lateral or dorsal subnuclei. The pattern of ChAT localization was thus complementary to the pattern of the habenular substance P projection to the IPN. Lesions of the FR eliminated all ChAT from the IPN while lesions of the stria medullaris produced a modest decrease. Unilateral FR lesions indicated that the FR projection to the central and rostral subnuclei is largely bilateral and symmetrical and that to the intermediate subnuclei is largely ipsilateral. We found no evidence of lesion-induced plasticity, i.e. replacement of ChAT immunoreactivity, by surviving FR axons in these adult brains.

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The MHb contains neurons that produce acetylcholine or substance P, and a small population that produces interleukin-18.
“MHb is comprised of neurons that produce the neurotransmitters acetylcholine (ACh) or substance P (Cuello et al. 1978;Eckenrode et al. 1987), and a small population that produce the cytokine interleukin-18 (IL-18) (Sugama et al. 2002).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Eckenrode et al. 1987

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A comparison of the subnuclear and ultrastructural distribution of acetycholinesterase and choline acetyltransferase in the rat interpeduncular nucleus
Kawaja, M. D., Flumerfelt, B. A., & Hrycyshyn, A. W. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90105-9 · Cited by 8 · see citing works

Authors: Eckenrode, T. C., Barr, G. A., Battisti, W. P., & Murray, M.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Eckenrode, T.C.
ORCID: Barr, G.A.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1987-08
Volume: 418
Issue: 2
Pages: 273-286
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(87)90095-3
OpenAlex: W1983174495
Cited by: 64
References: 63
Citations by year: 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 2
FWCI: 2.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS 16556)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: interpeduncular nucleus, cholinergic projections, choline acetyltransferase, habenula, fasciculus retroflexus, stria medullaris, deafferentation, axonal projections, lesion-induced plasticity, cholinergic neurons
MeSH terms: Acetylcholine, Animals, Choline O-Acetyltransferase, Electron Transport Complex IV, Diencephalon, Female, Histocytochemistry, Immunoenzyme Techniques, Mesencephalon, Microscopy, Electron, Neural Pathways, Neuronal Plasticity, Rats, Inbred Strains, Staining and Labeling, Rats

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Acetylcholine in the interpeduncular nucleus of the rat: normal distribution and effects of deafferentation

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