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Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line
Open accessAbstract
The toxicity of 3-hydroxykynurenine (3HK), an endogenous tryptophan metabolite which is markedly elevated in rat CNS tissue as a result of neonatal vitamin B-6 deficiency, was investigated in a neuronally derived hybrid cell line (N18-RE-105). At concentrations in excess of 100 microM, 3HK was toxic to greater than 85% of cultured cells over the course of 24 h. The time course of 3HK toxicity was studied in cultures exposed to 500 microM 3HK. Cell lysis proceeded linearly to completion in 8-12 h, but the toxic effects of exposure for 2 h were irreversible. 3HK was the most potently toxic among several related kynurenine metabolites tested. The toxic effects of 3HK exposure were markedly attenuated or abolished in the presence of either catalase or glutathione, indicating, a role of oxidative stress in 3HK toxicity.
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Cited by
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Schwarcz, R., Rassoulpour, A., Wu, H.-Q., Medoff, D., Tamminga, C. A., & Roberts, R. C. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01078-2 · Cited by 590
Okuda, S., Nishiyama, N., Saito, H., & Katsuki, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12553 · Cited by 301
Expression of The Kynurenine Pathway Enzymes in Human Microglia and Macrophages
Guillemin, G. J., Smith, D. G., Smythe, G. A., Armati, P. J., & Brew, G. J. (2003) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4615-0135-0_12 · Cited by 229
Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease
Lim, C. K., Fernández-Gomez, F. J., Braidy, N., Estrada, C., Costa, C., Costa, S., Bessede, A., Fernandez-Villalba, E., Zinger, A., Herrero, M. T., et al. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.009 · Cited by 159
Metadata
- Authors
- Eastman, C. L., & Guilarte, T. R.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1989-08
- Volume
- 495
- Issue
- 2
- Pages
- 225-231
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2063998898
- Cited by
- 161
- References
- 0
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Eastman, C. L., & Guilarte, T. R. (1989). Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line. Brain Research. https://doi.org/10.1016/0006-8993(89)90216-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
