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Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy
Open accessAbstract
It has been hypothesized on the basis of animal models of epilepsy that abnormal neural activity in epilepsy may be related to reorganized neural circuits that facilitate epileptogenesis. Little evidence of this was available for human epilepsy. This paper provides the first evidence of such reorganization of a hippocampal seizure focus in human temporal lobe epilepsy (TLE). This reorganization involves the selective loss of somatostatin and neuropeptide Y immunoreactive interneurons, and axonal sprouting of other neuropeptide Y neurons and dynorphin-A immunoreactive granule cells. This set of changes is not exactly like those that are reported in animal models.
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Cited by
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653
Yu, F. H., Mantegazza, M., Westenbroek, R. E., Robbins, C. A., Kalume, F., Burton, K. A., Spain, W. J., McKnight, G. S., Scheuer, T., & Catterall, W. A. (2006) · Nature Neuroscience · doi:10.1038/nn1754 · Cited by 1,173
Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2
Strauss, K. A., Puffenberger, E. G., Huentelman, M. J., Gottlieb, S., Dobrin, S. E., Parod, J. M., Stephan, D. A., & Morton, D. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052773 · Cited by 630
Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction
Goldberg, E. M., & Coulter, D. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3482 · Cited by 542
Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies
Cossart, R., Bernard, C., & Ben-Ari, Y. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.011 · Cited by 342
Metadata
- Authors
- de Lanerolle, N. C., Kim, J. H., Robbins, R. J., & Spencer, D. D.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1989-08
- Volume
- 495
- Issue
- 2
- Pages
- 387-395
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2042315877
- Cited by
- 927
- References
- 0
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- de Lanerolle, N. C., Kim, J. H., Robbins, R. J., & Spencer, D. D. (1989). Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain Research. https://doi.org/10.1016/0006-8993(89)90234-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
