Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction
Open accessAbstract
Epilepsy is a prevalent neurological disorder associated with significant morbidity and mortality, but the only available drug therapies target its symptoms rather than the underlying cause. The process that links brain injury or other predisposing factors to the subsequent emergence of epilepsy is termed epileptogenesis. Substantial research has focused on elucidating the mechanisms of epileptogenesis so as to identify more specific targets for intervention, with the hope of preventing epilepsy before seizures emerge. Recent work has yielded important conceptual advances in this field. We suggest that such insights into the mechanisms of epileptogenesis converge at the level of cortical circuit dysfunction.
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Malfunction of inhibitory interneurons is associated with several types of epilepsy.
“malfunction of inhibitory INs has been associated with the generation of several types of epilepsy”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Goldberg and Coulter, 2013
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“Although impairment of PV and Sst INs has been implicated in the generation of hypersynchronous activity and epilepsy (Goldberg and Coulter, 2013; Hunt et al., 2013; Ito-Ishida et al., 2015; Paz and Huguenard, 2015), there are differences in the recruitment and functional impact of these circuits that reflect the spec…”
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- Authors
- Goldberg, E. M., & Coulter, D. A.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Coulter, Douglas A.
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-04-18
- Volume
- 14
- Issue
- 5
- Pages
- 337-349
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3982383
- OpenAlex
- W2038933710
- Cited by
- 542
- References
- 176
- Citations by year
- 2026: 35 · 2025: 37 · 2024: 65 · 2023: 42 · 2022: 47 · 2021: 43 · 2020: 43 · 2019: 59 · 2018: 45 · 2017: 44 · 2016: 32 · 2015: 22 · 2014: 20 · 2013: 8
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS038572, R01NS032403, R01NS082046)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- epileptogenesis, epilepsy, neural circuit dysfunction, cortical circuits, brain injury, epilepsy prevention, antiepileptic drug targets
- MeSH terms
- Animals, Cerebral Cortex, Epilepsy, Humans, Models, Biological, Nerve Net, Signal Transduction
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