Cited by 542Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction

Open access
Goldberg, Ethan M., Coulter, Douglas A.·2013·Nature Reviews Neuroscience

Abstract

Epilepsy is a prevalent neurological disorder associated with significant morbidity and mortality, but the only available drug therapies target its symptoms rather than the underlying cause. The process that links brain injury or other predisposing factors to the subsequent emergence of epilepsy is termed epileptogenesis. Substantial research has focused on elucidating the mechanisms of epileptogenesis so as to identify more specific targets for intervention, with the hope of preventing epilepsy before seizures emerge. Recent work has yielded important conceptual advances in this field. We suggest that such insights into the mechanisms of epileptogenesis converge at the level of cortical circuit dysfunction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nrn3482

Cites

176 of 176 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [135]Buckmaster PS Noebels JL Avoli M Rogawski MA Olsen RW Delgado-Escueta AV Jasper’s Basic Mechanisms of the Epilepsies 4 416 431 Oxford Univ. Press 2012 22787592

Cited by

Sorted by citations

Authors
Goldberg, E. M., & Coulter, D. A.
Affiliations
Children's Hospital of Philadelphia (US)
Corresponding author
Coulter, Douglas A.
Venue
Nature Reviews Neuroscience
Published
2013-04-18
Volume
14
Issue
5
Pages
337-349
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2038933710
Cited by
542
References
176
Citations by year
2026: 35 · 2025: 37 · 2024: 65 · 2023: 42 · 2022: 47 · 2021: 43 · 2020: 43 · 2019: 59 · 2018: 45 · 2017: 44 · 2016: 32 · 2015: 22 · 2014: 20 · 2013: 8
FWCI
3.64
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS038572, R01NS032403, R01NS082046)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
epileptogenesis, epilepsy, neural circuit dysfunction, cortical circuits, brain injury, epilepsy prevention, antiepileptic drug targets
MeSH terms
Animals, Cerebral Cortex, Epilepsy, Humans, Models, Biological, Nerve Net, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review