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Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons
Open accessAbstract
The levels of the antioxidants, glutathione and ascorbate were measured in primary cultures of murine astrocytes and neurons. The concentration of glutathione (reduced, GSH + oxidized, GSSG) was high in cultured, differentiated (i.e. treated with dBcAMP) and undifferentiated (i.e. untreated) astrocytes: approximately 25 (n = 2) and 16.0 +/- 5.0 (n = 7) nmol/mg protein, respectively. In contrast, glutathione levels in neurons were low: less than or equal to 1.0 (n = 7) nmol/mg protein. Ascorbate could not be detected (less than 2 nmol/mg protein) in either cell type. The apparent lack of defense mechanisms against oxidative stress may in part account for the 'fragility' of neurons in culture. The physiological implications of glutathione compartmentation in brain are discussed.
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Cited by
Metabolism and functions of glutathione in brain
Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702
Mitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
Klivenyi, P., Andreassen, O. A., Ferrante, R. J., Dedeoglu, A., Mueller, G., Lancelot, E., Bogdanov, M., Andersen, J. K., Jiang, D., & Beal, M. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00001.2000 · Cited by 1,111
Dringen, R., Pfeiffer, B., & Hamprecht, B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00562.1999 · Cited by 589
Astrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580
Metadata
- Authors
- Raps, S. P., Lai, J. C. K., Hertz, L., & Cooper, A. J. L.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1989-07
- Volume
- 493
- Issue
- 2
- Pages
- 398-401
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1999357946
- Cited by
- 417
- References
- 0
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Raps, S. P., Lai, J. C. K., Hertz, L., & Cooper, A. J. L. (1989). Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons. Brain Research. https://doi.org/10.1016/0006-8993(89)91178-5
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