Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
Open accessAbstract
Glutathione peroxidase (GSHPx) is a critical intracellular enzyme involved in detoxification of hydrogen peroxide (H(2)O(2)) to water. In the present study we examined the susceptibility of mice with a disruption of the glutathione peroxidase gene to the neurotoxic effects of malonate, 3-nitropropionic acid (3-NP), and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). Glutathione peroxidase knock-out mice showed no evidence of neuropathological or behavioral abnormalities at 2-3 months of age. Intrastriatal injections of malonate resulted in a significant twofold increase in lesion volume in homozygote GSHPx knock-out mice as compared to both heterozygote GSHPx knock-out and wild-type control mice. Malonate-induced increases in conversion of salicylate to 2,3- and 2, 5-dihydroxybenzoic acid, an index of hydroxyl radical generation, were greater in homozygote GSHPx knock-out mice as compared with both heterozygote GSHPx knock-out and wild-type control mice. Administration of MPTP resulted in significantly greater depletions of dopamine, 3,4-dihydroxybenzoic acid, and homovanillic acid in GSHPx knock-out mice than those seen in wild-type control mice. Striatal 3-nitrotyrosine (3-NT) concentrations after MPTP were significantly increased in GSHPx knock-out mice as compared with wild-type control mice. Systemic 3-NP administration resulted in significantly greater striatal damage and increases in 3-NT in GSHPx knock-out mice as compared to wild-type control mice. The present results indicate that a knock-out of GSHPx may be adequately compensated under nonstressed conditions, but that after administration of mitochondrial toxins GSHPx plays an important role in detoxifying increases in oxygen radicals.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In 2011, the Dietary Supplements Information Expert Committee gave SP a Class A safety rating and allowed quality monographs for SP in the USP and National Formulary.
“Furthermore, in 2011, The Dietary Supplements Information Expert Committee assigned a Class A safety rating for SP and permitted the admission of quality monographs for SP in the United States Pharmacopeia and National Formulary [38].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762 · see citing works
Glutathione peroxidase activity in selenium-deficient rat liver
Lawrence, R. A., & Burk, R. F. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(76)90747-6 · Cited by 3,544 · see citing works
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947 · see citing works
Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626 · see citing works
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789 · see citing works
Aging, energy, and oxidative stress in neurodegenerative diseases
Beal, M. F. (1995) · Annals of Neurology · doi:10.1002/ana.410380304 · Cited by 1,434 · see citing works
Self-citationBederson, J. B., Pitts, L. H., Germano, I. M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. M. (1986) · Stroke · doi:10.1161/01.str.17.6.1304 · Cited by 1,277 · see citing works
Beal, M. F., Brouillet, E., Jenkins, B. G., Ferrante, R. J., Kowall, N. W., Miller, J., Storey, E., Srivastava, R., Rosen, B. R., & Hyman, B. T. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04181.1993 · Cited by 1,026 · see citing works
Self-citationLebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023 · see citing works
Fridovich, I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83102-7 · Cited by 964 · see citing works
Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410514 · Cited by 885 · see citing works
Self-citationMitochondrial defect in Huntington's disease caudate nucleus
Gu, M., Gash, M. T., Mann, V. M., Javoy‐Agid, F., Cooper, J. M., & Schapira, A. H. V. (1996) · Annals of Neurology · doi:10.1002/ana.410390317 · Cited by 758 · see citing works
A radical hypothesis for neurodegeneration
Olanow, C. W. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90070-3 · Cited by 722 · see citing works
Przedborski, S., Jackson-Lewis, V. R., Yokoyama, R., Shibata, T., Dawson, V. L., & Dawson, T. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4565 · Cited by 624 · see citing works
Ho, Y., Magnenat, J.-L., Bronson, R. T., Cao, J., Gargano, M. D., Sugawara, M., & Funk, C. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16644 · Cited by 562 · see citing works
Astrocytes protect neurons from hydrogen peroxide toxicity
Desagher, S., Glowinski, J., & Prémont, J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02553.1996 · Cited by 543 · see citing works
Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds
Tipton, K. F., & Singer, T. P. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13610.x · Cited by 540 · see citing works
Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations
Sies, H., Sharov, V. S., Klotz, L., & Briviba, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27812 · Cited by 488 · see citing works
Jenkins, B. G., Koroshetz, W. J., Beal, M. F., & Rosen, B. R. (1993) · Neurology · doi:10.1212/wnl.43.12.2689 · Cited by 479 · see citing works
Self-citationGlutathione peroxidase, glial cells and Parkinson's disease
Damier, P., Hirsch, É. C., Zhang, P., Agid, Y., & Javoy-Agid, F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90175-f · Cited by 466 · see citing works
Glutathione deficiency leads to mitochondrial damage in brain.
Jain, A., Mårtensson, J., Stole, E., Auld, P. A. M., & Meister, A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1913 · Cited by 428 · see citing works
Inhibition of neuronal nitric oxide synthase prevents MPTP–induced parkinsonism in baboons
Hantraye, P., Brouillet, E., Ferrante, R. J., Palfi, S., Dolan, R., Matthews, R. T., & Beal, M. F. (1996) · Nature Medicine · doi:10.1038/nm0996-1017 · Cited by 422 · see citing works
Self-citationGlutathione is present in high concentrations in cultured astrocytes but not in cultured neurons
Raps, S. P., Lai, J. C. K., Hertz, L., & Cooper, A. J. L. (1989) · Brain Research · doi:10.1016/0006-8993(89)91178-5 · Cited by 417 · see citing works
Brain Peroxidase and Catalase in Parkinson Disease
Ambani, L. M., Woert, M. H. V., & Murphy, S. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490440064010 · Cited by 404 · see citing works
Floyd, R. A., Watson, J. J., & Wong, P. K. (1984) · Journal of Biochemical and Biophysical Methods · doi:10.1016/0165-022x(84)90042-3 · Cited by 397 · see citing works
Involvement of Free Radicals in Excitotoxicity In Vivo
Schulz, J. B., Henshaw, D. R., Siwek, D. F., Jenkins, B. G., Ferrante, R. J., Cipolloni, P. B., Kowall, N. W., Rosen, B. R., & Beal, M. F. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052239.x · Cited by 322 · see citing works
Self-citationHasegawa, E., Takeshige, K., Oishi, T., Murai, Y., & Minakami, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90498-c · Cited by 320 · see citing works
Dexter, D. T., Sian, J., Rose, S., Hindmarsh, J. G., Mann, V. M., Cooper, J. A. D., Wells, F. R., Daniel, S. E., Lees, A. J., Schapira, A. H. V., et al. (1994) · Annals of Neurology · doi:10.1002/ana.410350107 · Cited by 317 · see citing works
Beal, M. F., Matson, W. R., Swartz, K. J., Gamache, P. H., & Bird, E. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb03143.x · Cited by 312 · see citing works
Self-citationGlutathione peroxidase activity in Parkinson's disease brain
Kish, S. J., Morito, C. L. H., & Hornykiewicz, O. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90078-3 · Cited by 301 · see citing works
Beal, M. F., Brouillet, E., Jenkins, B. G., Henshaw, R., Rosen, B. R., & Hyman, B. T. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03633.x · Cited by 297 · see citing works
Self-citationPhospholipid Hydroperoxides Are Substrates for Non-selenium Glutathione Peroxidase
Fisher, A. B., Dodia, C., Manevich, Y., Chen, J., & Feinstein, S. I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21326 · Cited by 295 · see citing works
Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo
Schulz, J. B., Matthews, R., Jenkins, B. G., Ferrante, R. J., Siwek, D. F., Henshaw, D. R., Cipolloni, P. B., Mecocci, P., Kowall, N. W., & Rosen, B. R. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-08419.1995 · Cited by 281 · see citing works
Self-citationHistochemical evaluation of glutathione in brain
Slivka, A., Mytilineou, C., & Cohen, G. (1987) · Brain Research · doi:10.1016/0006-8993(87)90712-8 · Cited by 249 · see citing works
Chiueh, C. C., Krishna, G. A., Tulsi, P., et al. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90151-6 · Cited by 235 · see citing works
Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice
Sriram, K., Pai, K. S., Boyd, M. R., & Ravindranath, V. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01271-1 · Cited by 226 · see citing works
Beal, M. F., Kowall, N. W., Swartz, K. J., et al. (1989) · Synapse · doi:10.1002/syn.890030106 · Cited by 195 · see citing works
Self-citationDringen, R., & Hamprecht, B. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00233-3 · Cited by 182 · see citing works
The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease
Bloem, B. R., Irwin, I., Buruma, O. J. S., Haan, J., Roos, R. A. C., Tetrud, J. W., & Langston, J. W. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90225-c · Cited by 160 · see citing works
Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones
Wüllner, U., Löschmann, P. A., Schulz, J. B., et al. (1996) · Neuroreport · doi:10.1097/00001756-199603220-00018 · Cited by 153 · see citing works
SUBCELLULAR DISTRIBUTION OF d ‐AMINO ACID OXIDASE AND CATALASE IN RAT BRAIN
Gaunt, G. L., & Duve, C. D. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb04447.x-i1 · Cited by 144 · see citing works
Depletion of brain glutathione by buthionine sulfoximine enhances cerebral ischemic injury in rats
Mizui, T., Kinouchi, H., & Chan, P. H. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.262.2.h313 · Cited by 138 · see citing works
Regional Distribution of Catalase in the Adult Rat Brain
Brannan, T. S., Maker, H. S., & Raes, I. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb02411.x · Cited by 129 · see citing works
Huang, J., & Philbert, M. A. (1995) · Brain Research · doi:10.1016/0006-8993(95)00209-9 · Cited by 129 · see citing works
REDUCTION OF γ‐AMINOBUTYRIC ACID LEVEL IN THE CAT CEREBRAL CORTEX BY AFFERENT ELECTRICAL STIMULATION
Lichtshtcin, D., & Dobkin, J. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb04448.x · Cited by 113 · see citing works
Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity
Schulz, J. B., Ross Henshaw, D., Matthews, R. T., & Flint Beal, M. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90033-0 · Cited by 103 · see citing works
Hung, H.-C., & Lee, E. H. Y. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00206-2 · Cited by 95 · see citing works
Oxidative Damage in Neurodegenerative Diseases
Beal, M. F. (1997) · The Neuroscientist · doi:10.1177/107385849700300112 · Cited by 89 · see citing works
Self-citationThe Role of Glutathione in Dopaminergic Neuronal Survival
Nakamura, K., Wang, W., & Kang, U. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69051850.x · Cited by 87 · see citing works
Pileblad, E., Magnusson, T., & Fornstedt, B. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb02550.x · Cited by 87 · see citing works
Hassel, B., & Sonnewald, U. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031184.x · Cited by 87 · see citing works
High‐Affinity Choline Transport Sites: Use of [3H]Hemicholinium‐3 as a Quantitative Marker
Happe, H. K., & Murrin, L. C. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03277.x · Cited by 80 · see citing works
Immunocytochemical localization of seleno-glutathione peroxidase in the adult mouse brain
Trépanier, G., Furling, D., Puymirat, J., & Mirault, M.-É. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00222-9 · Cited by 70 · see citing works
Decreased Glutathione Results in Calcium-Mediated Cell Death in PC12
Jurma, O. P., Hom, D. G., & Andersen, J. K. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00134-2 · Cited by 67 · see citing works
Self-citationAndersen, J. K., Mo, J. Q., Hom, D. G., Lee, F. Y., Harnish, P. P., Hamill, R. W., & McNeill, T. H. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67052164.x · Cited by 65 · see citing works
Self-citationAge‐Dependent Variations in Peroxide‐Utilizing Enzymes from Rat Brain Mitochondria and Cytoplasm
Vitórica, J., Machado, A., & Satrústegui, J. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb02685.x · Cited by 65 · see citing works
The Genetic Defect Causing Huntington’s Disease: Repeated in Other Contexts?
Gusella, J. F., Persichetti, F., & MacDonald, M. E. (1997) · Molecular Medicine · doi:10.1007/bf03401677 · Cited by 60 · see citing works
Marinho, H. S., Antunes, F., & Pinto, R. E. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00468-6 · Cited by 59 · see citing works
Copin, J. C., Ledig, M., & Tholey, G. (1992) · Neurochemical Research · doi:10.1007/bf00968004 · Cited by 35 · see citing works
Martı́nez, M., Ferrándiz, M. L., Dı́ez, A., & Miquel, J. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01644-f · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Alpha-band oscillations, attention, and controlled access to stored information
Klimesch, W. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.10.007 · Cited by 3,310 · see citing works
Distracted and confused? Selective attention under load
Lavie, N. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.12.004 · Cited by 2,102 · see citing works
Oxidative stress in neurodegeneration: Cause or consequence?
Andersen, J. K. (2004) · Nature Medicine · doi:10.1038/nrn1434 · Cited by 1,869 · see citing works
Self-citationMop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621 · see citing works
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502 · see citing works
Multiple dopamine functions at different time courses
Schultz, W. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135722 · Cited by 1,415 · see citing works
Mitochondrial metabolism of reactive oxygen species
Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336 · see citing works
Lubos, E., Loscalzo, J., & Handy, D. E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3586 · Cited by 1,280 · see citing works
Cross-modal plasticity: where and how?
Bavelier, D., & Neville, H. J. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn848 · Cited by 1,040 · see citing works
Expression of Nrf2 in Neurodegenerative Diseases
Ramsey, C. P., Glass, C. A., Montgomery, M. B., Lindl, K. A., Ritson, G. P., Chia, L. A., Hamilton, R. L., Chu, C. T., & Jordan-Sciutto, K. L. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e31802d6da9 · Cited by 760 · see citing works
How (and why) the immune system makes us sleep
Imeri, L., & Opp, M. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2576 · Cited by 710 · see citing works
Psychomotor stimulant addiction: a neural systems perspective
Everitt, B. J., & Wolf, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03312.2002 · Cited by 700 · see citing works
Distinct prefrontal cortex activity associated with item memory and source memory for visual shapes
Slotnick, S. D., Moo, L. R., Segal, J. B., & Hart, J. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00082-x · Cited by 654 · see citing works
Parietal cortex and representation of the mental Self
Lou, H. C., Luber, B., Crupain, M., Keenan, J. P., Nowak, M., Kjaer, T. W., Sackeim, H. A., & Lisanby, S. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400049101 · Cited by 631 · see citing works
Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo
Kaur, D., Yantiri, F., Rajagopalan, S., Kumar, J., Mo, J. Q., Boonplueang, R., Viswanath, V., Jacobs, R., Yang, L., Beal, M. F., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00126-0 · Cited by 620 · see citing works
Self-citationDolcos, F., LaBar, K. S., & Cabeza, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409848102 · Cited by 601 · see citing works
Fries, P., Womelsdorf, T., Oostenveld, R., & Desimone, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4499-07.2008 · Cited by 458 · see citing works
Neuronal Mechanisms and Attentional Modulation of Corticothalamic Alpha Oscillations
Bollimunta, A., Mo, J., Schroeder, C. E., & Ding, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5580-10.2011 · Cited by 441 · see citing works
Neuronal Mechanisms of Cortical Alpha Oscillations in Awake-Behaving Macaques
Bollimunta, A., Chen, Y., Schroeder, C. E., & Ding, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2699-08.2008 · Cited by 434 · see citing works
Alpha power increases in right parietal cortex reflects focused internal attention
Benedek, M., Schickel, R. J., Jauk, E., Fink, A., & Neubauer, A. C. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.02.010 · Cited by 354 · see citing works
Daselaar, S. M., Rice, H. J., Greenberg, D. L., Cabeza, R., LaBar, K. S., & Rubin, D. C. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm048 · Cited by 341 · see citing works
Quantitative assessment of prefrontal cortex in humans relative to nonhuman primates
Donahue, C. J., Glasser, M. F., Preuss, T. M., Rilling, J. K., & Van Essen, D. C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721653115 · Cited by 301 · see citing works
Lee, J.-M., Shih, A. Y., Murphy, T. H., & Johnson, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305204200 · Cited by 308 · see citing works
Mueller, D., Porter, J. T., & Quirk, G. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3248-07.2008 · Cited by 284 · see citing works
Yang, J.-W., Hanganu-Opatz, I. L., Sun, J.-J., & Luhmann, H. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5646-08.2009 · Cited by 276 · see citing works
Molecular and cellular permeability control at the blood-brain barrier
Gloor, S. M., Wachtel, M., Bolliger, M. F., Ishihara, H., Landmann, R., & Frei, K. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00102-3 · Cited by 244 · see citing works
Synaptic regulation of translation of dendritic mRNAs
Schuman, E. M., Dynes, J. L., & Steward, O. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1796-06.2006 · Cited by 230 · see citing works
Common and Distinct Mechanisms of Cognitive Flexibility in Prefrontal Cortex
Kim, C., Johnson, N. F., Cilles, S. E., & Gold, B. T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5923-10.2011 · Cited by 216 · see citing works
Zinc Triggers Microglial Activation
Kauppinen, T. M., Higashi, Y., Suh, S. W., Escartin, C., Nagasawa, K., & Swanson, R. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1236-08.2008 · Cited by 174 · see citing works
Pandey, S. C., Roy, A., & Zhang, H. (2003) · Alcoholism: Clinical and Experimental Research · doi:10.1097/01.alc.0000056616.81971.49 · Cited by 168 · see citing works
Downregulation of Parvalbumin at Cortical GABA Synapses Reduces Network Gamma Oscillatory Activity
Volman, V., Behrens, M. M., & Sejnowski, T. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3041-11.2011 · Cited by 164 · see citing works
Randomized, double‐blind, pilot evaluation of intravenous glutathione in Parkinson's disease
Hauser, R. A., Lyons, K. E., McClain, T., Carter, S., & Perlmutter, D. (2009) · Movement Disorders · doi:10.1002/mds.22401 · Cited by 143 · see citing works
Compulsive behavior in the 5-HT2C receptor knockout mouse
Chou-Green, J. M., Holscher, T. D., Dallman, M. F., & Akana, S. F. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00047-7 · Cited by 143 · see citing works
Jay, T. M., Rocher, C., Hotte, M., Naudon, L., Gurden, H., & Spedding, M. (2004) · Neurotoxicity Research · doi:10.1007/bf03033225 · Cited by 141 · see citing works
Alpha and theta band dynamics related to sentential constraint and word expectancy
Rommers, J., Dickson, D. S., Norton, J. J. S., Wlotko, E. W., & Federmeier, K. D. (2017) · Language, Cognition and Neuroscience · doi:10.1080/23273798.2016.1183799 · Cited by 109 · see citing works
Dodds, C. M., Muller, U., Clark, L., van Loon, A., Cools, R., & Robbins, T. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1153-08.2008 · Cited by 113 · see citing works
Ruggiero, R. N., Rossignoli, M. T., Marques, D. B., de Sousa, B. M., Romcy-Pereira, R. N., Lopes-Aguiar, C., & Leite, J. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.732360 · Cited by 111 · see citing works
Ku, C. S., Pham, T. X., Park, Y., Kim, B., Shin, M. S., Kang, I., & Lee, J. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.01.018 · Cited by 109 · see citing works
Characterizing the roles of alpha and theta oscillations in multisensory attention
Keller, A. S., Payne, L., & Sekuler, R. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.02.021 · Cited by 106 · see citing works
Regional Dendritic Variation in Neonatal Human Cortex: A Quantitative Golgi Study
Travis, K., Ford, K., & Jacobs, B. (2005) · Developmental Neuroscience · doi:10.1159/000086707 · Cited by 89 · see citing works
Stress Impairs Episodic Retrieval by Disrupting Hippocampal and Cortical Mechanisms of Remembering
Gagnon, S. A., Waskom, M. L., Brown, T. I., & Wagner, A. D. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy162 · Cited by 69 · see citing works
Peng, J., Xie, L., Stevenson, F. F., Melov, S., Di Monte, D. A., & Andersen, J. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3447-06.2006 · Cited by 53 · see citing works
Self-citationDelisle, J., & Braun, C. M. J. (2011) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acr043 · Cited by 49 · see citing works
Effects of l-theanine on attention and reaction time response
Higashiyama, A., Htay, H. H., Ozeki, M., Juneja, L. R., & Kapoor, M. P. (2011) · Journal of Functional Foods · doi:10.1016/j.jff.2011.03.009 · Cited by 50 · see citing works
- Authors
- Klivenyi, P., Andreassen, O. A., Ferrante, R. J., Dedeoglu, A., Mueller, G., Lancelot, E., Bogdanov, M., Andersen, J. K., Jiang, D., & Beal, M. F.
- Affiliations
- Harvard University (US)
- Boston University (US)
- University of Southern California (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-01-01
- Volume
- 20
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6774090
- OpenAlex
- W1946022517
- Cited by
- 1,111
- References
- 60
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 8 · 2020: 20 · 2019: 20 · 2018: 20 · 2017: 30 · 2016: 37 · 2015: 35 · 2014: 38 · 2013: 48 · 2012: 32
- FWCI
- 59.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ns031579-05, NS31579)
- National Institute of Neurological Disorders and Stroke (NS10828, F32NS010828, NS 16367, NS31579, P50NS016367, P50NS010828, P01NS010828)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Keywords
- glutathione peroxidase, malonate, 3-nitropropionic acid, MPTP, neurotoxicity, oxidative stress, hydroxyl radicals, dopamine depletion, nitrotyrosine, striatal lesions, mitochondrial toxins, hydrogen peroxide detoxification, salicylate metabolism
- MeSH terms
- Animals, Brain Chemistry, Catechols, Convulsants, Corpus Striatum, Disease Models, Animal, Female, Free Radicals, Glutathione, Glutathione Peroxidase, Heterozygote, Homovanillic Acid, Homozygote, Huntington Disease, Male, Malonates, Mice, Inbred Strains, Nitro Compounds, Parkinson Disease, Secondary, Propionates, Tyrosine, 3,4-Dihydroxyphenylacetic Acid, Dopamine Agents, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Mice, Knockout, Oxidative Stress, MPTP Poisoning, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
