Reduction of arginine vasopressin binding sites in mouse lateral septum by treatment with 6-hydroxydopamine
Abstract
The neuropeptide arginine vasopressin modulates neuroadaptive processes, including memory consolidation and functional tolerance to ethanol, by actions at CNS V1 receptors. Noradrenergic systems play a role in these actions of the peptide. To assess whether vasopressin may act presynaptically on catecholamine neurons, vasopressin receptors were measured by quantitative autoradiography in the lateral septum, an area that is innervated by catecholaminergic neurons and has a high density of V1 receptors, of control and 6-hydroxydopamine-treated mice. Vasopressin receptors were distributed non-uniformly throughout the lateral septum, with greater binding in the more caudal regions. Treatment with 6-hydroxydopamine lowered septal catecholamine levels and vasopressin binding, with a greater effect on binding in the intermediate and caudal portions of the lateral septum. Pretreatment with desmethylimipramine reversed the depletion of norepinephrine, and attenuated the effect of 6-hydroxydopamine on vasopressin binding in the intermediate region, but was less effective in the caudal region of the lateral septum. The results suggest that a portion of septal vasopressin receptors are localized on the terminals of noradrenergic and, possibly, dopaminergic neurons, consistent with the hypothesis that certain neuroadaptive responses to vasopressin could be mediated by modulation of neurotransmitter release. In contrast to the results with 6-hydroxydopamine, treatment of mice with 5,7-dihy…
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Treatment with 6-hydroxydopamine reduces LS-DA and LS-NE concentrations as well as LS-AVP binding.
“treatment with 6-hydroxydopamine, a neurotoxin that selectively destroys DA and NE neurons in the brain, reduced LS-DA and LS-NE concentrations as well as LS-AVP binding [41].”
From Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin (2018) · cites this paper as [41]
In adult male mice, a portion of V1aR is located on terminals of dopaminergic neurons innervating the LS.
“Some evidence in adult male mice suggests that a portion of V1aR is located on terminals of dopaminergic neurons innervating the LS [41].”
From Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin (2018) · cites this paper as [41]
Treatment with 6-hydroxydopamine combined with desmethylimipramine reduces LS-DA concentrations and LS-AVP binding.
“treatment with 6-hydroxydopamine combined with the highly specific NE reuptake inhibitor desmethylimipramine, that prevents 6-hydroxydopamine to destroy NE neurons, reduced LS-DA concentrations as well as LS-AVP binding [41].”
From Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin (2018) · cites this paper as [41]
Cites
Buijs, R. M., & Swaab, D. F. (1979) · Cell and Tissue Research · doi:10.1007/bf00233648 · Cited by 262 · see citing works
Dopamine and noradrenaline neurons projecting to the septal area in the rat
Lindvall, O., & Stenevi, U. (1978) · Cell and Tissue Research · doi:10.1007/bf00219554 · Cited by 195 · see citing works
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Dluzen, D. E., Muraoka, S., & Landgraf, R. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00691-0 · Cited by 89 · see citing works
Bredewold, R., Nascimento, N. F., Ro, G. S., Cieslewski, S. E., Reppucci, C. J., & Veenema, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0100-2 · Cited by 31 · see citing works
- Authors
- Ishizawa, H., Tabakoff, B., Mefford, I. N., & Hoffman, P. L.
- Affiliations
- National Institutes of Health (US)
- National Institute of Mental Health (US)
- Corresponding author
- Hoffman, Paula L.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 507
- Issue
- 2
- Pages
- 189-194
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1984348668
- Cited by
- 28
- References
- 2
- Citations by year
- 2018: 1 · 2013: 1 · 2012: 1
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin, V1 receptor, lateral septum, 6-hydroxydopamine, catecholamine depletion, norepinephrine, desmethylimipramine, noradrenergic neurons, dopaminergic neurons, serotonin, neural adaptation, memory consolidation, ethanol tolerance
- MeSH terms
- Animals, Hydroxydopamines, Male, Mice, Inbred C57BL, Neurotoxins, Receptors, Angiotensin, Septal Nuclei, Oxidopamine, Receptors, Vasopressin, Mice
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