Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats
Abstract
Male rats were implanted bilaterally with cannulae directed at the olfactory bulbs and infused with either vehicle or 6-OHDA to selectively deplete norepinephrine concentrations at this site. At 5-7 days following this treatment, these animals received a bilateral infusion of either arginine vasopressin (AVP) or oxytocin (OXT) through these same guide cannulae and were then tested for their capacity to maintain social recognition responses. Neither infusion of AVP nor OXT were able to preserve recognition responses in the animals treated with 6-OHDA. In contrast, comparably tested animals who received a vehicle infusion showed clear recognition responses following either the AVP or OXT infusion. These results suggest that this capacity for these neuropeptides to preserve social recognition responses is mediated through the norepinephrine system of the olfactory bulb.
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Oxytocin administered intracerebroventricularly can induce full maternal behavior in less than a minute in estrogen-primed nonpregnant ewes.
“Furthermore, OT administered intracerebroventricularly can induce full maternal behavior in less than a minute in estrogen-primed nonpregnant ewes [33].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [33]
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- Authors
- Dluzen, D. E., Muraoka, S., & Landgraf, R.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Max Planck Society (DE)
- Corresponding author
- Dluzen, Dean E
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 254
- Issue
- 3
- Pages
- 161-164
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1977125554
- Cited by
- 89
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- olfactory bulb, norepinephrine depletion, 6-hydroxydopamine, vasopressin, oxytocin, social recognition, social behavior
- MeSH terms
- Animals, Arginine Vasopressin, Infusions, Parenteral, Male, Norepinephrine, Olfactory Bulb, Oxytocin, Social Behavior, Time Factors, Oxidopamine, Rats, Wistar, Rats
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