Developmental immunohistochemistry of catalase in the human brain
Abstract
The immunohistochemical studies on a peroxisomal enzyme, catalase, were done on brains from human fetuses to adults. The catalase-positive neurons appeared in the basal ganglia, thalamus and cerebellum at 27-28 weeks of gestation, and in the frontal cortex at 35 weeks. They then increased in number with gestational age. The extent of immunopositive staining increased with enlargement of perikaryonal size. However, the extent gradually decreased with postnatal age. On the other hand, catalase-positive glia appeared in the deep white matter at 31-32 weeks of gestation, their appearance shifting from the deep to the superficial white matter with increasing age. These results suggest that peroxisomes are closely related to neuronal growth and myelinogenesis in the human brain during development.
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In the brain, peroxisomes have been detected in all neural cell types: neurons, oligodendrocytes, astrocytes, microglia and endothelial cells.
“In the brain, peroxisomes appear as electron-dense single membrane-bound organelles that have been detected in all neural cell types, namely in neurons [13], oligodendrocytes [14,15] and astrocytes [13] and microglia and endothelial cells [16].”
From Peroxisomes in brain development and function (2016) · cites this paper as [15]
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Peroxisomes in brain development and function
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“In the human brain, catalase-positive neurons emerged early in evolutionary old structures such as the basal ganglia, the thalamus and the cerebellum (about 27–28 weeks of gestation), whereas in the frontal cortex, they appeared later (around 35 weeks of gestation) [15].”
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Expression of the adrenoleukodystrophy protein in the human and mouse central nervous system
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- Authors
- Houdou, S., Kuruta, H., Hasegawa, M., Konomi, H., Takashima, S., Suzuki, Y., & Hashimoto, T.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- Gifu University (JP)
- Shinshu University (JP)
- Corresponding author
- Houdou, Sadataka
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1991-08
- Volume
- 556
- Issue
- 2
- Pages
- 267-270
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2031022721
- Cited by
- 59
- References
- 20
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- catalase, peroxisomes, human brain development, fetal brain, gestational age, postnatal development, basal ganglia, thalamus, cerebellum, frontal cortex, glia, white matter, myelination, neuronal growth
- MeSH terms
- Adolescent, Adult, Aging, Brain, Catalase, Child, Child, Preschool, Fetus, Humans, Immunohistochemistry, Infant, Infant, Newborn, Kidney, Liver, Microbodies, Neuroglia
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