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Cited by 53Sexual Differentiation and DisordersStress Responses and CortisolSperm and Testicular Function

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Prenatal stress alters sexually dimorphic nuclei in the spinal cord of male rats

Grisham, William, Kerchner, Michael, Ward, Ingeborg L.·1991·Brain Research
DOI 10.1016/0006-8993(91)90922-i
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Abstract

The spinal nucleus bulbocavernosus (SNB), the dorsolateral nucleus of the spinal cord (DLN), and the bulbocavernosus/levator ani (BC/LA) muscle complex were examined in prenatally stressed and control adult male rats, which had been screened for male copulatory behavior. There was a small but significant decrease in the number of DLN (5%) and SNB (3%) neurons in prenatally stressed males compared to controls. Prenatal stress had no effect on the somal or nuclear area of individual neurons within either nucleus, nor did it affect the weight of the BC/LA muscle complex. There were no differences in any of these measures between males that ejaculated and those did not in either the stressed or the control group. These data suggest that exposure of pregnant rats to transient environmental stressors may result in permanent alterations in androgen-sensitive CNS structures in their male offspring.

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Research works printed but not linked: 38

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Metadata

Authors
Grisham, W., Kerchner, M., & Ward, I. L.
Affiliations
  • Rosemont College (US)
  • Villanova University (US)
Corresponding author
Ward, Ingeborg L.
ORCID
Grisham, William
Venue
Brain Research
Publisher
Elsevier BV
Published
1991-06
Volume
551
Issue
1-2
Pages
126-131
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(91)90922-i
OpenAlex
W2054580944
Cited by
53
References
1
Citations by year
2022: 2 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k05mh000049-15, 5r01hd004688-23)
  • National Institute of Mental Health (2-K05-MH-00049)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD04688)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
prenatal stress, spinal cord, neuron number, male copulatory behavior, ejaculatory behavior, environmental stressors, male rats
MeSH terms
Analysis of Variance, Animals, Female, Fetus, Male, Pregnancy, Pregnancy Complications, Rats, Inbred Strains, Sexual Behavior, Animal, Sex Characteristics, Spinal Cord, Stress, Physiological, Rats

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