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Cited by 104Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNeural dynamics and brain function

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Actions of noradrenaline on neocortical neurons in vitro

Dodt, Hans-Ulrich, Pawelzik, Hannelore, Zieglga¨nsberger, Walter·1991·Brain Research
DOI 10.1016/0006-8993(91)91303-i
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Abstract

The effects of noradrenaline (NA) and alpha- and beta-adrenergic agonists on neocortical neurons in rat brain slices were studied by intracellular recording. NA added to the perfusion medium decreased the orthodromically evoked excitatory postsynaptic potential (EPSP) and increased the neuronal excitability on current injection. The decrease of the EPSP by NA was mimicked by alpha-adrenoceptor activation. The beta-adrenergic agonist, isoprenaline, increased the neuronal excitability to current injections similarly to NA. In addition, isoprenaline markedly increased the amplitude of a late component of the EPSP (I-EPSP). The increase of the I-EPSP was long-lasting (up to 90 min). Since this late component of the EPSP is blocked by the NMDA (N-methyl-D-aspartate)-antagonist APV (D-2-amino-5-phosphonovalerate), an enhancement of this excitatory synaptic transient via beta-adrenoceptors may be relevant for the facilitatory effect of NA on neuronal plasticity.

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Research works printed but not linked: 1

  1. Bergmann-Erb, 1988, Biogenic amines facilitateN-methyl-dl-aspartate responses in the guinea-pig neocortex in vitro, Pfu¨ger's Arch., R127

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Metadata

Authors
Dodt, H.-U., Pawelzik, H., & Zieglga¨nsberger, W.
Affiliations
  • Max Planck Society (DE)
  • Max Planck Institute of Psychiatry (DE)
Corresponding author
Dodt, Hans-Ulrich
ORCID
Dodt, Hans-Ulrich
Venue
Brain Research
Publisher
Elsevier BV
Published
1991-04
Volume
545
Issue
1-2
Pages
307-311
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(91)91303-i
OpenAlex
W2049173488
Cited by
104
References
29
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 3
FWCI
1.57
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
norepinephrine, neocortical neurons, alpha-adrenergic receptors, beta-adrenergic receptors, isoproterenol, excitatory postsynaptic potentials, neuronal excitability, NMDA receptor, synaptic plasticity
MeSH terms
Action Potentials, Animals, Electric Conductivity, Electric Stimulation, Evoked Potentials, Isoproterenol, Male, Neurons, Norepinephrine, Rats, Inbred Strains, Somatosensory Cortex, 2-Amino-5-phosphonovalerate, N-Methylaspartate, Rats, In Vitro Techniques

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