Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
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1. The effects of excitatory amino acids and some antagonists applied by ionophoresis to stratum radiatum in the CA1 region of rat hippocampal slices were examined on the locally recorded field e.p.s.p. evoked by stimulation of the Schaffer collateral-commissural projection. 2. L-glutamate, L-aspartate and the more potent and selective excitatory amino acids quisqualate, kainate and N-methyl-DL-aspartate (NMA) depressed the e.p.s.p., presumably through depolarization and/or a change in membrane conductance. 3. The depression induced by kainate considerably outlasted the period of ejection whereas NMA depressions were rapidly reversible and were often followed by a potentiation of the e.p.s.p. In higher doses NMA also depressed the presynaptic fibre volley. The possible involvement of these effects in neurotoxicity and synaptic plasticity is raised. 4. The selective NMA antagonist, DL-2-amino-5-phosphonovalerate (APV) applied in doses which abolished responses to NMA, had no effect on the e.p.s.p. but prevented long term potentiation (l.t.p.) of synaptic transmission evoked by high frequency stimulation of the Schaffer collateral-commissural pathway. Other antagonists which had little or no effect on normal synaptic transmission included D-alpha-aminoadipate (DAA), the optical isomers of 2-amino-4-phosphonobutyrate (APB) and L-glutamate diethylester (GDEE). 5. In contrast, gamma-D-glutamylglycine (DGG), applied in amounts which affected quisqualate and kainate actions as well…
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Application of NMDAR antagonists such as AP5 completely blocks the induction of LTP in most hippocampal synapses.
“For instance, application of NMDAR antagonists (such as 2-amino-5-phosphonopropionic acid [AP5]) completely blocks the induction of LTP in most hippocampal synapses (Collingridge et al., 1983; Zalutsky and Nicoll, 1990; Hanse and Gustafsson, 1992).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Collingridge et al., 1983
The NMDA type of glutamate receptor (NMDAR) is required for LTP.
“The mechanism underlying these features relies on the N-methyl-d-aspartate (NMDA) type of glutamate receptor (NMDAR), which is known to be required for LTP (42).”
From Synaptic memory and CaMKII (2023) · cites this paper as [42]
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- Authors
- Collingridge, G. L., Kehl, S. J., & McLennan, H.
- ORCID
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1983-01
- Volume
- 334
- Issue
- 1
- Pages
- 33-46
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1197298
- OpenAlex
- W2058148599
- Cited by
- 2,413
- References
- 0
- Citations by year
- 2026: 15 · 2025: 14 · 2024: 28 · 2023: 14 · 2022: 23 · 2021: 46 · 2020: 35 · 2019: 26 · 2018: 36 · 2017: 31 · 2016: 45 · 2015: 33 · 2014: 46 · 2013: 45 · 2012: 39
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- excitatory amino acids, synaptic transmission, Schaffer collateral-commissural pathway, hippocampal CA1, stratum radiatum, field EPSP, NMDA receptor, kainate receptors, quisqualate receptors, glutamate, L-aspartic acid, long-term potentiation, synaptic plasticity, presynaptic depression, APV, gamma-D-glutamylglycine, excitatory amino acid antagonists, neurotoxicity
- MeSH terms
- Action Potentials, Amino Acids, Animals, Electric Conductivity, Hippocampus, Neural Pathways, Synaptic Transmission, Synapses, Rats, In Vitro Techniques
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