Disappearance of circadian rhythms in Parkinson's disease model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in dogs
Abstract
Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to dogs produces clinical, pathological and neurological features in dog resembling human Parkinson's disease. Using this animal model, we studied the changes in diurnal rhythms of urine volume, creatinine in urine, and vasopressin, aldosterone and renin activity in plasma. Before MPTP treatment, urine volume showed a peak between 17.00 and 1.00 and plasma vasopressin concentration also showed a clear circadian rhythm with a peak at 13.00 and a minimum level at 5.00. Two weeks after MPTP treatment (2.5 mg/kg i.v.), the rhythm of urine volume disappeared and that of vasopressin became less clear. Plasma renin activity increased 2 and 4 weeks after MPTP treatment. The increase was, however, not enough to change the concentration of plasma aldosterone. We examined the effect of L-3,4-dihydroxyphenylalanine (levodopa), on the circadian pattern of urine volume and vasopressin attenuated by MPTP. Levodopa (4 mg/kg/day) was administered orally every day from the first week after MPTP treatment. The circadian rhythms of urine volume and vasopressin reappeared within one week after the start of levodopa administration.
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MPTP-treated dogs exhibit blunted circadian oscillations in renal parameters, including urine volume, creatinine and several hormones.
“Further, MPTP-treated dogs exhibit blunted circadian oscillations in renal parameters, including urine volume, creatinine and several hormones (Hineno et al., 1992).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Hineno et al., 1992
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Circadian dysregulation in Parkinson's disease
Videnovic, A., & Golombek, D. (2017) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.11.001 · Cited by 63 · see citing works
- Authors
- Hineno, T., Mizobuchi, M., Hiratani, K., Inami, Y., & Kakimoto, Y.
- Affiliations
- Ehime University (JP)
- Ehime University Hospital (JP)
- Corresponding author
- Hineno, Takashi
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 580
- Issue
- 1-2
- Pages
- 92-99
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2012974140
- Cited by
- 34
- References
- 32
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 5 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Abbott Japan
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, MPTP, circadian rhythm, urine output, vasopressin, aldosterone, renin activity, diurnal cycle, levodopa, animal models, dogs
- MeSH terms
- Aldosterone, Animals, Circadian Rhythm, Disease Models, Animal, Dogs, Male, Parkinson Disease, Secondary, Renin, Vasopressins, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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