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Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging
Abstract
The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is implicated in the temporal organization of circadian rhythms in a variety of physiological, endocrine and behavioral processes. There is a great deal of evidence indicating that aging is characterized by a progressive deterioration of circadian timekeeping. The present study was aimed at investigating whether there are age-related changes in circadian rhythmicity of the vasopressin (VP)-producing neurons in the human SCN. To that end brains obtained at autopsy of 39 subjects, ranging in age from 6 to 91 years, were studied. Subjects were divided into two age groups, viz. 'young subjects' (up to 50 years) and 'elderly subjects' (over 50 years). It is shown that the number of VP-immunoreactive neurons in the human SCN exhibits a marked diurnal oscillation in young, but not in elderly, people. Whereas in young subjects low VP-immunoreactive neuron numbers were found during the night period (22:00-06:00 h) and peak values during the early morning (06:00-10:00 h), the SCN of elderly people showed a reduced amplitude and a tendency for a reversed diurnal pattern with high instead of low values during the night. The findings suggest that the VP synthesis of the human SCN exhibits a circadian rhythm that is disrupted later in life.
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“Circadian disruptions are ubiquitous in modern society, affected by the modern lighting environment and negatively impacting health from in utero development through old age79–81.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [81]
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Metadata
- Authors
- Hofman, M. A., & Swaab, D. F.
- Corresponding author
- Hofman, Michel A.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 651
- Issue
- 1-2
- Pages
- 134-142
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2028499883
- Cited by
- 215
- References
- 72
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 10 · 2013: 8 · 2012: 9
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- suprachiasmatic nucleus, vasopressin, circadian rhythm, aging, diurnal variation, circadian timekeeping, human brain, hypothalamus, age-related changes
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Child, Circadian Rhythm, Female, Humans, Male, Middle Aged, Neurons, Suprachiasmatic Nucleus, Vasopressins
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