Vasopressin: Behavioral roles of an “original” neuropeptide

Caldwell, Heather K.; Lee, Heon-Jin; Macbeth, Abbe H.; Young, W. Scott

doi:10.1016/j.pneurobio.2007.10.007

Cited by 504Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Vasopressin: Behavioral roles of an “original” neuropeptide

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Caldwell, Heather K., Lee, Heon-Jin, Macbeth, Abbe H., Young, W. Scott·2008·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2007.10.007PMC PMC2292122

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Abstract

Vasopressin (Avp) is mainly synthesized in the magnocellular cells of the hypothalamic supraoptic (SON) and paraventricular nuclei (PVN) whose axons project to the posterior pituitary. Avp is then released into the blood stream upon appropriate stimulation (e.g., hemorrhage or dehydration) to act at the kidneys and blood vessels. The brain also contains several populations of smaller, parvocellular neurons whose projections remain within the brain. These populations are located within the PVN, bed nucleus of the stria terminalis (BNST), medial amygdala (MeA) and suprachiasmatic nucleus (SCN). Since the 1950s, research examining the roles of Avp in the brain and periphery has intensified. The development of specific agonists and antagonists for Avp receptors has allowed for a better elucidation of its contributions to physiology and behavior. Anatomical, pharmacological and transgenic, including "knockout," animal studies have implicated Avp in the regulation of various social behaviors across species. Avp plays a prominent role in the regulation of aggression, generally of facilitating or promoting it. Affiliation and certain aspects of pair-bonding are also influenced by Avp. Memory, one of the first brain functions of Avp that was investigated, has been implicated especially strongly in social recognition. The roles of Avp in stress, anxiety, and depressive states are areas of active exploration. In this review, we concentrate on the scientific progress that has been made in understanding the role of Avp in regulating these and other behaviors across species. We also discuss the implications for human behavior.

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AVP has been implicated in a number of adult social behaviors.
“The neuropeptide arginine vasopressin (AVP) has been implicated in a number of adult social behaviors (reviewed in Caldwell et al., 2008).”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as Caldwell et al., 2008
OT has a single receptor (OTR); AVP has three receptors (V1aR, V1bR, V2R), with V1aR the principal receptor implicated in social processes.
“OT has a single receptor (OTR) both in the periphery and in the brain. AVP has three receptors (V1aR, V1bR, and V2R); V1bR and V2R are expressed primarily in the periphery, and while V1aR and V1bR are present in the brain, V1aR is the principal receptor implicated in social processes (Gainer and Wray 1994; Burbach et al 2005; for a review of the AVP system and behavior see Caldwell et al 2008; for”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Caldwell et al 2008
AVP ligand binding to V1aR activates two potential signaling cascades via Gq and Gi/o proteins, which can open nonspecific cationic channels or close K+ channels.
“AVP ligand binding to V1aR activates two potential signaling cascades via Gq and Gi/o proteins, which can open nonspecific cationic channels or close K+ channels (reviewed in Caldwell et al., 2008; Gimpl and Fahrenholz, 2001).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Caldwell et al., 2008
OT ligand binding to OTR activates multiple G proteins that can exert diverse effects on cell function, including stimulation of cAMP (Gs), inhibition of adenylyl cyclase (Gi/o), stimulation of potassium channel currents (Gi) and activation of phospholipase C (Gq).
“OT ligand binding to OTR activates multiple G proteins that can exert diverse effects on cell function, including stimulation of cAMP (Gs), inhibition of adenylyl cyclase (Gi/o), stimulation of potassium channel currents (Gi) and activation of phospholipase C (Gq).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Caldwell et al., 2008

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“HAB rats display greater depressive- and anxiety-like behaviors that are accompanied by enhanced stress-induced secretion of ACTH and corticosterone than LAB rats (Landgraf et al., 1999; Landgraf, 2006).”
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Orally active vasopressin V1a receptor antagonist, SRX251, selectively blocks aggressive behavior
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Circadian rhythms in vasopressin deficient rats
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Differential Transcriptional Regulation of Rat Vasopressin Gene Expression by Estrogen Receptor α and β**This work was supported by Public Health Service Grant NS20311 and the Alzheimer’s Disease Research Center of the University of Washington, AG-05136. These sequence data have been submitted to the DNA Database of Japan/European Molecular Biology Laboratory/GenBank databases under accession number AF112362.
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Chapter 14 Molecular pharmacology and modeling of vasopressin receptors
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Functional and Pharmacological Characterization of the First Specific Agonist and Antagonist for the V1b Receptor in Mammals
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Authors: Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S.
Affiliations: United States Department of Health and Human Services (US)
Corresponding author: Young, W. Scott
ORCID: Caldwell, Heather K.
Lee, Heon-Jin
Young, W. Scott
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2008-01
Volume: 84
Issue: 1
Pages: 1-24
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2007.10.007
PMC: PMC2292122
OpenAlex: W2007086728
Cited by: 504
References: 327
Citations by year: 2026: 13 · 2025: 22 · 2024: 29 · 2023: 12 · 2022: 16 · 2021: 25 · 2020: 31 · 2019: 19 · 2018: 19 · 2017: 31 · 2016: 21 · 2015: 22 · 2014: 39 · 2013: 43 · 2012: 42
FWCI: 3.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (Z01MH002498)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: vasopressin, neuropeptides, social behavior, aggression, pair bonding, social recognition memory, stress, anxiety, depression, vasopressin receptor, parvocellular neurons, magnocellular neurons, hypothalamus, suprachiasmatic nucleus, bed nucleus of the stria terminalis, medial amygdala, knockout mice
MeSH terms: Aggression, Animals, Behavior, Animal, Brain, Humans, Hypothalamo-Hypophyseal System, Memory, Social Behavior, Stress, Psychological, Vasopressins, Receptors, Vasopressin

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Vasopressin: Behavioral roles of an “original” neuropeptide

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