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Pontine respiratory neurons in anesthetized cats

Dick, Thomas E., Bellingham, Mark C., Richter, Diethelm W.·1994·Brain Research
DOI 10.1016/0006-8993(94)91025-1
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Abstract

The pontine respiratory neurons (PRG) in the 'pneumotaxic centre' have been hypothesized to contribute to phase-switching of neural respiratory activity, especially in terminating inspiration. To define the neural elements involved in phase-switching, we recorded respiratory neurons extra- and intracellularly in anesthetized cats with an intact central nervous system. In total, 54 neurons were recorded: 49 neurons with activity modulated by central respiratory rhythm (20 inspiratory, 17 postinspiratory and 12 expiratory) and 5 neurons with activity correlated to tracheal pressure. The recorded neurons were clustered in dorsolateral pontine tegmentum within the Kölliker-Fuse (KF) subnucleus of the parabrachial nuclei. Stable intracellular membrane potential was recorded in 11 of the 49 respiratory neurons (8 postinspiratory, 1 early inspiratory and 2 inspiratory). During continuous injection of chloride ions (n = 6), synaptic noise increased and IPSPs reversed, including a wave of IPSPs during stage-2 expiration in postinspiratory neurons. Further, relative input resistance varied through the respiratory cycle such that the least input resistance occurred during the neuron's (n = 5) quiescent period. No IPSPs nor EPSPs were evoked in pontine respiratory neurons by vagal stimulation. In conclusion, various types of respiratory neurons were recorded in the KF nucleus. Prominent excitatory and inhibitory postsynaptic activities were similar to those described for medullary neuron…

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Research works printed but not linked: 49

  1. Bertrand, 1971, Respiratory synchronizing function of nucleus parabrachialis medialis: pneumotaxic mechanisms, J. Neurophysiol., 34, 189, 10.1152/jn.1971.34.2.189 · DOI
  2. Bertrand, 1974, A stereologic model of pneumotaxic oscillator based on spatial and temporal distributions of neuronal bursts, J. Neurophysiol., 37, 91, 10.1152/jn.1974.37.1.91 · DOI
  3. Bianchi, 1981, Pontile axonal projections of medullary respiratory neurons, Resp. Physiol., 45, 167, 10.1016/0034-5687(81)90058-X · DOI
  4. Bianchi, 1982, Medullary axonal projections of respiratory neurons of pontile pneumotaxic center, Resp. Physiol., 48, 357, 10.1016/0034-5687(82)90039-1 · DOI
  5. Caille, 1981, Apneusis and apnea after parabrachial of Ko¨lliker-Fuse N. lesion: influence of wakefulness, Resp. Physiol., 45, 79, 10.1016/0034-5687(81)90051-7 · DOI · Paper page
  6. Cohen, 1971, Switching of the respiratory phases and evoked phrenic responses produced by rostral pontine electrical stimulation, J. Physiol., 217, 133, 10.1113/jphysiol.1971.sp009563 · DOI
  7. Cohen, 1979, Neurogenesis of respiratory rhythm in the mammal, Physiol. Rev., 59, 1105, 10.1152/physrev.1979.59.4.1105 · DOI
  8. Cohen, 1981, Central determinants of respiratory rhythm, Annu. Rev. Physiol., 43, 91, 10.1146/annurev.ph.43.030181.000515 · DOI
  9. Cohen, 1981, Pulmonary afferent and central influences on respiratory phase-switching in the cat, Can. J. Physiol. Pharmacol., 59, 675, 10.1139/y81-103 · DOI
  10. Cohen, 1959, Respiratory neuronal activity in pons of cat, J. Neurophysiol., 22, 33, 10.1152/jn.1959.22.1.33 · DOI
  11. Euler, 1976, Effects of lesioning the parabrachial nucleus on the mechanisms for central and reflex termination of inspiration in the cat, Acta Physiol. Scand., 96, 324, 10.1111/j.1748-1716.1976.tb10203.x · DOI
  12. Ezure, 1990, Synaptic connections between medullary respiratory neurons and considerations on the genesis of respiratory rhythm, Prog. Neurobiol., 35, 429, 10.1016/0301-0082(90)90030-K · DOI
  13. Feldman, 1976, A network model for control of inspiratory cutoff by the pneumotaxic center with supportive experimental data in cats, Biol. Cybern., 21, 131, 10.1007/BF00337420 · DOI
  14. Feldman, 1976, The interaction of pulmonary afferents and pneumotaxic center in control of respiratory pattern in cats, J. Neurophysiol., 39, 31, 10.1152/jn.1976.39.1.31 · DOI
  15. Feldman, 1976, Powerful inhibition of pontine respiratory neurons by pulmonary afferent activity, Brain Res., 104, 341, 10.1016/0006-8993(76)90629-6 · DOI
  16. Feldman, 1992, Synaptic interaction between medullary respiratory neurones during apneus is induced by NMDA-receptor blockade in cat, J. Physiol., 450, 303, 10.1113/jphysiol.1992.sp019128 · DOI
  17. Foutz, 1988, N-Methyl-d-aspartate (NMDA) receptors control respiratory off-switch in cat, Neurosci. Lett., 87, 221, 10.1016/0304-3940(88)90452-1 · DOI
  18. Glogowska, 1988, Respiratory activity of the pons and its influence on breathing in the guinea pig, Acta Neurobiol. Exp., 48, 125
  19. Herbert, 1990, Connections of the parabrachial nucleus with the nucleus of the solitary tract and medullary reticular formation in the rat, J. Comp. Neurol., 293, 540, 10.1002/cne.902930404 · DOI
  20. Huang, 1993, Cerebellar control of expiratory activities of medullary neurons and spinal nerves, J. Appl. Physiol., 74, 1934, 10.1152/jappl.1993.74.4.1934 · DOI
  21. Hukuhara, 1981, Localization and functional organization of bulbar and pontine respiratory neurons in the rabbit, Adv. Physiol. Sci., 10, 579
  22. Karius, 1991, Brain Res., 559, 22, 10.1016/0006-8993(91)90282-Z · DOI
  23. King, 1980, Topology of ascending brainstem projections to nucleus parabrachialis in the cat, J. Comp. Neurol., 191, 615, 10.1002/cne.901910408 · DOI
  24. Ling, 1993, Pontine-evoked inspiratory inhibitions after antagonism of NMDA, GABAA, or glycine receptor, J. Appl. Physiol., 74, 1265, 10.1152/jappl.1993.74.3.1265 · DOI
  25. Lumsden, 1923, Observations on the respiratory centers in the cat, J. Physiol., 57, 153, 10.1113/jphysiol.1923.sp002052 · DOI
  26. Lutherer, L.O. and Williams, J.L., Stimulating fastigial nucleus pressor region elicits patterned respiratory responses,Am. J. Physiol., 250. · DOI
  27. Lydic, 1979, Respiratory neurons of the pneumotaxic center during sleep and wakefulness, Neurosci. Lett., 15, 187, 10.1016/0304-3940(79)96111-1 · DOI
  28. Monteau, 1989, Pneumotaxic centre and apneustic breathing: interspecies differences between rat and cat, Neurosci. Lett., 99, 311, 10.1016/0304-3940(89)90465-5 · DOI
  29. Netick, 1981, Erroneous classification of neuronal activity by the respiratory modulation index, Neurosci. Lett., 21, 301, 10.1016/0304-3940(81)90221-4 · DOI
  30. Oku, 1992, Phase resetting of the respiratory cycle before and after unilateral pontine lesion in cat, J. Appl. Physiol., 72, 721, 10.1152/jappl.1992.72.2.721 · DOI
  31. Panneton, 1991, Primary afferent projections from the upper respiratory tract in the muskrat, J. Comp. Neurol., 308, 51, 10.1002/cne.903080106 · DOI
  32. Paton, J.F.R., Cerebellar control of cardiovascular activity. In A.D. Loewy and K.M. Spyer, (Eds.),Central Control of the Autonomic Nervous System, Oxford University Press, Oxford, in press.
  33. Remmers, 1986, Reflex prolongation of stage I of expiration, Pflu¨gers Arch., 407, 190, 10.1007/BF00580675 · DOI
  34. Richter, 1982, Generation of maintenance of the respiratory rhythm, J. Exp. Biol., 100, 93, 10.1242/jeb.100.1.93 · DOI
  35. Richter, 1975, Intracellular recordings from different types of medullary respiratory neurons of the cat, J. Neurophysiol., 38, 1162, 10.1152/jn.1975.38.5.1162 · DOI
  36. Richter, 1979, Studies on the synaptic interconnection between bulbar respiratory neurones of cats, Pflu¨gers Arch., 380, 245, 10.1007/BF00582903 · DOI
  37. Richter, 1986, How is the respiratory rhythm generated? A model, News Physiol. Sci., 1, 109
  38. Richter, 1987, The differential organization of medullary postinspiratory activities, Pflu¨gers Arch., 410, 420, 10.1007/BF00586520 · DOI
  39. Richter, 1992, Mechanisms of respiratory rhythm generation, Curr. Opin. Neurobiol., 2, 788, 10.1016/0959-4388(92)90135-8 · DOI
  40. Segers, 1985, Interaction between rostral pontine and ventral medullary respiratory neurons, J. Neurophysiol., 54, 318, 10.1152/jn.1985.54.2.318 · DOI
  41. Shannon, 1983, Intercostal and abdominal muscle afferent influence on pneumotaxic center respiratory neurons, Resp. Physiol., 52, 85, 10.1016/0034-5687(83)90138-X · DOI
  42. Shaw, 1989, Inspiratory-modulated neurons of the rostrolateral pons: effects of pulmonary afferent input, Brain Res., 485, 179, 10.1016/0006-8993(89)90681-1 · DOI
  43. Sieck, 1980, Pneumotaxic area neuronal discharge during sleep-waking states in the cat, Exp. Neurol., 67, 79, 10.1016/0014-4886(80)90162-4 · DOI
  44. Sieck, 1981, Absence of high-frequency oscilation in the discharge of pneumotaxic neurons in intact unanesthetized cats, Brain Res., 221, 397, 10.1016/0006-8993(81)90790-3 · DOI
  45. Smith, 1989, Brainstem projections to the major respiratory neuron populations in the medulla of the cat, J. Comp. Neurol., 281, 69, 10.1002/cne.902810107 · DOI
  46. Smith, 1991, Pre-Bo¨tzinger Complex: a brainstem region that may generate respiratory rhythm in mammals, Science, 254, 726, 10.1126/science.1683005 · DOI
  47. St. John, 1987, Influence of pulmonary inflations on discharge of pontile respiratory neurons, J. Appl. Physiol., 63, 2231, 10.1152/jappl.1987.63.6.2231 · DOI
  48. St. John, 1985, Genesis of rhythmic respiratory activity in pons independent of medulla, J. Appl. Physiol., 59, 684, 10.1152/jappl.1985.59.3.684 · DOI
  49. Takagi, 1958, Respiratory discharge of the pons, Sci., 128, 1206, 10.1126/science.128.3333.1206 · DOI

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Metadata

Authors
Dick, T. E., Bellingham, M. C., & Richter, D. W.
Venue
Brain Research
Publisher
Elsevier BV
Published
1994-02
Volume
636
Issue
2
Pages
259-269
ISSN
0006-8993
DOI
10.1016/0006-8993(94)91025-1
Cited by
109
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Pontine respiratory neurons in anesthetized cats. https://app.cochat.ai/papers/10.1016/0006-8993(94)91025-1
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Dick, T. E., Bellingham, M. C., & Richter, D. W. (1994). Pontine respiratory neurons in anesthetized cats. Brain Research. https://doi.org/10.1016/0006-8993(94)91025-1