Bicuculline blocks neuropeptide Y-induced phase advances when microinjected in the suprachiasmatic nucleus of Syrian-hamsters
Abstract
Microinjection of neuropeptide Y (NPY) into the suprachiasmatic nucleus of the hypothalamus (SCN) during the middle of the subjective day (i.e. circadian time 6) causes large phase advances in circadian rhythms. The present study demonstrates that microinjection of the gamma-aminobutyric acid (GABA) antagonist, bicuculline, completely blocks NPY-induced phase advances. These data indicate that GABAA activity within the SCN may mediate the phase shifting effects of some stimuli on the circadian pacemaker.
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Injection of AVP into several brain sites, including the anterior hypothalamus, lateral septum, and periaqueductal gray, induces robust bouts of flank marking in Syrian hamsters.
“Injection of AVP into several brain sites including the anterior hypothalamus (AH), the lateral septum (LS), and the periaqueductal gray (PAG), induce robust bouts of flank marking [55; 56; 57; 58].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [58]
Cites
A functional analysis of circadian pacemakers in nocturnal rodents
Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology A · doi:10.1007/bf01417856 · Cited by 2,129 · see citing works
Fuxé, K. (1965) · PubMed · Cited by 1,544 · see citing works
A retinohypothalamic projection in the rat
Moore, R. Y., & Lenn, N. J. (1972) · The Journal of Comparative Neurology · doi:10.1002/cne.901460102 · Cited by 1,263 · see citing works
A Functional analysis of circadian pacemakers in nocturnal rodents
Daan, S., & Pittendrigh, C. S. (1976) · Journal of Comparative Physiology A · doi:10.1007/bf01417857 · Cited by 683 · see citing works
GABA: A dominant neurotransmitter in the hypothalamus
Decavel, C., & van den Pol, A. N. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020423 · Cited by 571 · see citing works
GABA is the principal neurotransmitter of the circadian system
Moore, R. Y., & Speh, J. C. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90120-a · Cited by 555 · see citing works
An autoradiographic and electron microscopic study of retino-hypothalamic connections
Hendrickson, A. E., Wagoner, N. E., & Cowan, W. M. (1972) · Cell and Tissue Research · doi:10.1007/bf00307084 · Cited by 493 · see citing works
Neuropeptide Y: Role in light-dark cycle entrainment of hamster circadian rhythms
Albers, H. E., & Ferris, C. F. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90480-4 · Cited by 451 · see citing works
Self-citationSwanson, L. W., Cowan, W. M., & Jones, E. G. (1974) · The Journal of Comparative Neurology · doi:10.1002/cne.901560203 · Cited by 423 · see citing works
Organization of lateral geniculate‐hypothalamic connections in the rat
Card, J. P., & Moore, R. Y. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840110 · Cited by 299 · see citing works
A benzodiazepine used in the treatment of insomnia phase-shifts the mammalian circadian clock
Turek, F. W., & Losee-Olson, S. H. (1986) · Nature · doi:10.1038/321167a0 · Cited by 246 · see citing works
Serotonin distribution in the nuclei of the rat hypothalamus and preoptic region
Saavedra, J. M., Palkovits, M., Brownstein, M., & Axelrod, J. (1974) · Brain Research · doi:10.1016/0006-8993(74)90812-9 · Cited by 244 · see citing works
Neuropeptide Y immunoreactivity in the hamster geniculo-suprachiasmatic tract
Harrington, M. E., Nance, D. M., & Rusak, B. (1985) · Brain Research Bulletin · doi:10.1016/0361-9230(85)90037-1 · Cited by 236 · see citing works
Lateral geniculate lesions block circadian phase-shift responses to a benzodiazepine.
Johnson, R. F., Smale, L., Moore, R. Y., & Morin, L. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5301 · Cited by 181 · see citing works
Moore, R., Gustafson, E. L., & Card, J. P. (1984) · Cell and Tissue Research · doi:10.1007/bf00216511 · Cited by 174 · see citing works
Rusak, B., Meijer, J. H., & Harrington, M. E. (1989) · Brain Research · doi:10.1016/0006-8993(89)91163-3 · Cited by 171 · see citing works
Ralph, M., & Menaker, M. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02858.1989 · Cited by 149 · see citing works
Huhman, K. L., & Albers, H. E. (1994) · Peptides · doi:10.1016/0196-9781(94)90126-0 · Cited by 135 · see citing works
Self-citationElectron microscopy of degeneration within the serotonin pathway of rat brain
Aghajanian, G. K., Bloom, F. E., & Sheard, M. H. (1969) · Brain Research · doi:10.1016/0006-8993(69)90286-8 · Cited by 130 · see citing works
Okamura, H., Bérod, A., Julien, J.-F., Geffard, M., Kitahama, K., Mallet, J. J., & Bobillier, P. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90067-0 · Cited by 128 · see citing works
Effects of diazepam on circadian phase advances and delays
Ralph, M. R., & Menaker, M. (1986) · Brain Research · doi:10.1016/0006-8993(86)91154-6 · Cited by 113 · see citing works
Central administration of muscimol phase-shifts the mammalian circadian clock
Smith, R. D., Inouye, S.-I. T., & Turek, F. W. (1989) · Journal of Comparative Physiology A · doi:10.1007/bf00616752 · Cited by 98 · see citing works
François‐Bellan, A., Kachidian, P., Dusticier, G., Tonon, M., Vaudry, H., & Bosler, O. (1990) · Journal of Neurocytology · doi:10.1007/bf01186821 · Cited by 62 · see citing works
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Albus, H., Vansteensel, M. J., Michel, S. H., Block, G. D., & Meijer, J. H. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.051 · Cited by 328 · see citing works
Cole, R. L., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00959.2002 · Cited by 253 · see citing works
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244 · see citing works
Self-citationMarchant, E. G., Watson, N. V., & Mistlberger, R. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-20-07974.1997 · Cited by 155 · see citing works
Chen, G., & van den Pol, A. N. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07711.1996 · Cited by 121 · see citing works
Neurotransmitters of the suprachiasmatic nuclei
Reghunandanan, V., & Reghunandanan, R. (2006) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-4-2 · Cited by 118 · see citing works
Serotonergic regulation of circadian rhythms in Syrian hamsters
Mintz, E. M., Gillespie, C. F., Marvel, C. L., Huhman, K. L., & Albers, H. E. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00696-3 · Cited by 116 · see citing works
Self-citationAlbers, H. E., Walton, J. C., Gamble, K. L., McNeill, J. K., & Hummer, D. L. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.11.003 · Cited by 113 · see citing works
Self-citationGribkoff, V. K., Pieschl, R. L., Wisialowski, T. A., van den Pol, A. N., & Yocca, F. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-08-03014.1998 · Cited by 108 · see citing works
Neuropeptide Y and glutamate block each other's phase shifts in the suprachiasmatic nucleus in vitro
Biello, S. M., Golombek, D. A., & Harrington, M. E. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00547-7 · Cited by 106 · see citing works
Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability
Harvey, J. R. M., Plante, A. E., & Meredith, A. L. (2020) · Physiological Reviews · doi:10.1152/physrev.00027.2019 · Cited by 101 · see citing works
Gillespie, C. F., Mintz, E. M., Marvel, C. L., Huhman, K. L., & Albers, H. E. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00235-7 · Cited by 99 · see citing works
Self-citationGillette, M. U., Abbott, S. M., & Arnold, J. M. (2012) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2012.06.001 · Cited by 79 · see citing works
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Biello, S. M., Golombek, D. A., Schak, K. M., & Harrington, M. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08468.1997 · Cited by 78 · see citing works
Korbonits, M., Little, Forsling, M. L., Tringali, Costa, A. C., Navarra, Trainer, P. J., & Grossman (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00353.x · Cited by 78 · see citing works
Circadian clock resetting in the mouse changes with age
Biello, S. M. (2009) · AGE · doi:10.1007/s11357-009-9102-7 · Cited by 76 · see citing works
Challet, É., Scarbrough, K., Penev, P. D., & Turek, F. W. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000237 · Cited by 70 · see citing works
Cardinali, D. P., & Golombek, D. A. (1998) · Neurochemical Research · doi:10.1023/a:1022426519297 · Cited by 65 · see citing works
Obrietan, K. H., & van den Pol, A. N. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03521.1996 · Cited by 61 · see citing works
Mintz, E. M., Jasnow, A. M., Gillespie, C. F., Huhman, K. L., & Albers, H. E. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00519-x · Cited by 59 · see citing works
Self-citationImmunohistochemical localization of the neuropeptide Y Y1 receptor in rat central nervous system
Migita, K., Loewy, A. D., Ramabhadran, T. V., Krause, J. E., & Waters, S. M. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03092-4 · Cited by 55 · see citing works
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Self-citationNovak, C. M., & Albers, H. E. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00575.2003 · Cited by 47 · see citing works
Self-citationRhythms of Glutamic Acid Decarboxylase mRNA in the Suprachiasmatic Nucleus
Huhman, K. L., Hennessey, A. C., & Albers, H. E. (1996) · Journal of Biological Rhythms · doi:10.1177/074873049601100404 · Cited by 46 · see citing works
Self-citationMeyer-Bernstein, E. L., & Morin, L. P. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000327 · Cited by 46 · see citing works
Ehlen, J. C., Novak, C. M., Karom, M. C., Gamble, K. L., Paul, K. N., & Albers, H. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04857.x · Cited by 40 · see citing works
Self-citationPrimeaux, S. D., Holmes, P. V., Martin, R. J., Dean, R. G., & Edwards, G. L. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01137-x · Cited by 37 · see citing works
Schuhler, S., Pitrosky, B., Saboureau, M., Lakhdar‐Ghazal, N., & Pévet, P. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01914-9 · Cited by 34 · see citing works
Ehlen, J. C., & Paul, K. N. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90878.2008 · Cited by 33 · see citing works
The SCN is Comprised of a Population of Coupled Oscillators
Miller, J. D. (1998) · Chronobiology International · doi:10.3109/07420529808998704 · Cited by 33 · see citing works
Light and GABAA receptor activation alter Period mRNA levels in the SCN of diurnal Nile grass rats
Novak, C. M., Ehlen, J. C., Paul, K. N., Fukuhara, C., & Albers, H. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05166.x · Cited by 31 · see citing works
Self-citationNeuropeptide y, gaba and circadian phase shifts to photic stimuli
Lall, G. S., & Biello, S. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00396-8 · Cited by 31 · see citing works
Functional Significance of the Excitatory Effects of GABA in the Suprachiasmatic Nucleus
McNeill, J. K., Walton, J. C., & Albers, H. E. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418782820 · Cited by 27 · see citing works
Self-citationHuhman, K. L., Marvel, C. L., Gillespie, C. F., Mintz, E. M., & Albers, H. E. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00831-7 · Cited by 27 · see citing works
Self-citationHall, A. C., Earle‐Cruikshanks, G., & Harrington, M. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00761.x · Cited by 27 · see citing works
Walton, J. C., McNeill, J. K., Oliver, K. A., & Albers, H. E. (2017) · eNeuro · doi:10.1523/eneuro.0352-16.2017 · Cited by 25 · see citing works
Self-citationNovak, C. M., & Albers, H. E. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.3.498 · Cited by 21 · see citing works
Self-citationEhlen, J. C., Novak, C. M., Karom, M. C., Gamble, K. L., & Albers, H. E. (2008) · Journal of Biological Rhythms · doi:10.1177/0748730407310785 · Cited by 20 · see citing works
Self-citationGamble, K. L., Ehlen, J. C., & Albers, H. E. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.03.004 · Cited by 20 · see citing works
Self-citationGamble, K. L., Novak, C. M., & Albers, H. E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.018 · Cited by 19 · see citing works
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Self-citationResponses to neuropeptide Y in adult hamster suprachiasmatic nucleus neurones in vitro
Cutler, D. J., Piggins, H. D., SELBIE, L. A., & Mason, R. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00012-0 · Cited by 17 · see citing works
Photic and nonphotic inputs to the diurnal circadian clock
Novak, C. M., Ehlen, J. C., & Albers, H. E. (2008) · Biological Rhythm Research · doi:10.1080/09291010701683482 · Cited by 13 · see citing works
Self-citationGillette, M. U., & Abbott, S. M. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.01.005 · Cited by 12 · see citing works
A Role for Thalamic Projection GABAergic Neurons in Circadian Responses to Light
Brock, O., Gelegen, Ç., Salgarella, I., Sully, P., Jager, P., Menage, L., Mehta, I. S., Jeczmien‐Lazur, J. S., Djama, D. S., Strother, L. C., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0112-21.2022 · Cited by 10 · see citing works
Mikkelsen, J. D., Karle, J., & Madsen, T. M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00446-9 · Cited by 10 · see citing works
Basic Mechanisms of Circadian Rhythms and their Relation to the Sleep/Wake Cycle
Gillette, M. U., & Abbott, S. M. (2006) · Springer eBooks · doi:10.1007/0-387-23692-9_2 · Cited by 7 · see citing works
Neuropeptide Y blocks GABAB-induced phase-shifts of the suprachiasmatic circadian clock in vitro
Biggs, K. R., & Prosser, R. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01104-x · Cited by 7 · see citing works
Hormonal Modulation of Central Motivational States
Schulkin, J. A. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50012-3 · Cited by 5 · see citing works
Intercellular Interactions and the Physiology of Circadian Rhythms in Mammals
Piggins, H. D., & Rusak, B. (2019) · CRC Press eBooks · doi:10.1201/9780429114373-3 · Cited by 5 · see citing works
GABA Involvement in the Circadian Regulation of Sleep
Ehlen, J. C., Hummer, D. L., Paul, K. N., & Albers, H. E. (2010) · Springer eBooks · doi:10.1007/978-3-0346-0226-6_14 · Cited by 4 · see citing works
Self-citationGrowing evidence that some aspects of SCN function differ in nocturnal and diurnal rodents
Lee, T. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00024.2004 · Cited by 4 · see citing works
Peptidergic Mechanisms of Action in the Suprachiasmatic Nucleusa
Huhman, K. L., Gillespie, C. F., Marvel, C. L., & Albers, H. E. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb46168.x · Cited by 2 · see citing works
Self-citationEffects of Neonatal Clomipramine Treatment on Photic and Non-Photic Circadian Phase Shifting in Rats
Dwyer, S. M. (2000) · DigitalCommons (California Polytechnic State University)
Intercellular Interactions and the Physiology of Circadian Rhythms in Mammals
Piggins, H. D., & Rusak, B. (1998) · CRC Press eBooks · doi:10.1201/9780849331510.ch3
- Authors
- Huhman, K. L., Babagbemi, T. O., & Albers, H. E.
- Affiliations
- Georgia State University (US)
- Corresponding author
- Huhman, K.L.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-03
- Volume
- 675
- Issue
- 1-2
- Pages
- 333-336
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2147933292
- Cited by
- 56
- References
- 23
- Citations by year
- 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2012: 1
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NS30022)
- National Institute of Mental Health (MH10178)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- neuropeptide Y, bicuculline, suprachiasmatic nucleus, circadian phase shift, GABAA receptor, circadian pacemaker, hypothalamus, golden hamster
- MeSH terms
- Animals, Bicuculline, Cricetinae, Male, Mesocricetus, Microinjections, Neuropeptide Y, Receptors, GABA-A, Regression Analysis, Suprachiasmatic Nucleus, GABA-A Receptor Antagonists
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