Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 459

The DOI matches its Crossref record.

Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims

Open access
Arango, Victoria, Underwood, Mark D., Gubbi, Ananda V., Mann, J. John·1995·Brain Research
DOI 10.1016/0006-8993(95)00523-s
Open this paper in CoChat — free account

Abstract

Altered serotonin indices have been reported in the brain of suicide victims. We sought to localize the changes in presynaptic and postsynaptic serotonin receptors and identify an area of prefrontal cortex that may influence suicide risk. Quantitative autoradiography was performed in coronal sections of prefrontal cortex to determine whether serotonin 5-HT1A receptor (postsynaptic in cortex) and serotonin transporter (presynaptic) binding are different in suicide victims compared to matched controls. 5-HT1A receptor binding was higher in 85 of the 103 sampled areas in the suicide group (n = 18 pairs; P < 0.0001). The increase ranged from 17 to 30%. The increase was more pronounced in the ventrolateral prefrontal cortex. Serotonin transporter binding was found to be lower in the suicide group in all but one of the 43 sampled regions (n = 22 pairs; P < 0.0001). The reduction in binding was most pronounced in the ventrolateral prefrontal cortex, where the difference between suicides and controls ranged between 15 and 27%. Serotonin transporter and 5-HT1A binding were negatively correlated (r = -0.35 to -0.44, P = 0.04 to 0.007) within the same brain areas, suggesting common regulatory factors with opposite effects on binding to the two receptors. We conclude that suicide victims have an abnormality in the serotonin system involving predominantly the ventrolateral prefrontal cortex, and hypothesize that the serotonergic dysfunction in this brain region contributes to the risk for suicidal behavior.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/0006-8993(95)00523-s

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 75

  1. Arango, 1990, Autoradiographic demonstration of increased serotonin 5-HT2 and β-adrenergic receptor binding sites in the brain of suicide victims, Arch. Gen. Psychiatry, 47, 1038, 10.1001/archpsyc.1990.01810230054009 · DOI · Paper page
  2. Arango, 1992, Relevance of serotonergic postmortem studies to suicidal behavior, Int. Rev. Psychiatry, 4, 131, 10.3109/09540269209066310 · DOI
  3. Arango, 1991, Quantitative autoradiography of 5-HT1A binding in suicide, Soc. Neurosci. Abstr., 17, 1472
  4. Arango, 1994, Localized alterations in pre-and postsynaptic serotonin binding sites in prefrontal cortex of suicide victims, Soc. Neurosci. Abstr., 20, 26
  5. Arató, 1987, Serotonergic split brain and suicide, Psychiatry Res., 21, 355, 10.1016/0165-1781(87)90019-9 · DOI
  6. Arató, 1991, Reversed hemispheric asymmetry of imipramine binding in suicide victims, Biol. Psychiatry, 29, 699, 10.1016/0006-3223(91)90143-A · DOI
  7. Arora, 1989, 3H-imipramine binding in the frontal cortex of suicides, Psychiatry Res., 30, 125, 10.1016/0165-1781(89)90154-6 · DOI
  8. Arora, 1991, Laterality and 3H-imipramine binding: Studies in the frontal cortex of normal controls and suicide victims, Biol. Psychiatry, 29, 1016, 10.1016/0006-3223(91)90358-S · DOI
  9. Ågren, 1980, Symptom patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid. II. Suicide, Psychiatry Res., 3, 225, 10.1016/0165-1781(80)90039-6 · DOI · Paper page
  10. Åsberg, 1976, 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor?, Arch. Gen. Psychiatry, 33, 1193, 10.1001/archpsyc.1976.01770100055005 · DOI · Paper page
  11. Banki, 1984, Biochemical markers in suicidal patients. Investigations with cerebrospinal fluid amine metabolites and neuroendocrine tests, J. Affect. Disord., 6, 341, 10.1016/S0165-0327(84)80012-9 · DOI · Paper page
  12. Beskow, 1976, Determination of monoamine and monoamine metabolites in the human brain: post mortem studies in a group of suicides and in a control group, Acta Psychiat. Scand., 53, 7, 10.1111/j.1600-0447.1976.tb00054.x · DOI · Paper page
  13. Bourne, 1968, Noradrenalin, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in hindbrain of suicidal patients, Lancet, ii, 805, 10.1016/S0140-6736(68)92459-8 · DOI · Paper page
  14. Bradley, 1986, Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine, Neuropharmacology, 25, 563, 10.1016/0028-3908(86)90207-8 · DOI · Paper page
  15. Branchek, 1993, Receptor diversity: more serotonin receptors, Curr. Biol., 3, 315, 10.1016/0960-9822(93)90190-Y · doi:10.1016/0960-9822(93)90190-y
  16. Brousseau, 1991, 5-HT depletion alters the levels of 5-HT1a receptor mRNA, Soc. Neurosci., 17, 719
  17. Brown, 1982, Human aggression and suicide: their relationship to neuropsychiatric diagnoses and serotonin metabolism, Adv. Biochem. Psychopharmacol., 34, 287
  18. Carpenter, 1993, Strong inference, theory testing, and the neuroanatomy of schizophrenia, Arch. Gen. Psychiatry, 50, 825, 10.1001/archpsyc.1993.01820220081009 · DOI · Paper page
  19. Cash, 1985, High and low affinity [3H]imipramine binding sites in control and Parkinsonian brains, Eur. J. Pharmacol., 117, 71, 10.1016/0014-2999(85)90473-X · DOI
  20. Center for Disease Control and Prevention, 1993, Advance report of final mortality statistics, 1990, Mthly Vital Stat. Report, 41, 1
  21. Cheetham, 1990, Brain 5-HT1 binding sites in depressed suicides, Psychopharmacology (Berlin), 102, 544, 10.1007/BF02247138 · DOI · Paper page
  22. Coccaro, 1989, Serotonergic studies in patients with affective and personality disorders, Arch. Gen. Psychiatry, 46, 587, 10.1001/archpsyc.1989.01810070013002 · DOI · Paper page
  23. Crow, 1984, Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides, Neuropharmacology, 23, 1561, 10.1016/0028-3908(84)90100-X · DOI · Paper page
  24. D'Amato, 1987, Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine, J. Pharmacol. Exp. Ther., 242, 364, 10.1016/S0022-3565(25)39080-4 · DOI · Paper page
  25. Damasio, 1994, The return of Phineas Gage: clues about the brain from the skull of famous patient, Science, 264, 1102, 10.1126/science.8178168 · DOI · Paper page
  26. Dillion, 1991, Autoradiography analysis of serotonin 5-HT1A receptor binding in the human brain postmortem: Effects of age and alcohol, Brain Res., 554, 56, 10.1016/0006-8993(91)90171-Q · DOI · Paper page
  27. Dumbrille-Ross, 1983, Binding of [3H]Ro 11-2465. Possible identification of a subclass of [3H]imipramine binding sites, Mol. Pharmacol., 23, 607, 10.1016/S0026-895X(25)14306-X · DOI
  28. Dumuis, 1989, The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons, Naunyn Schmiedebergs Arch. Pharmacol., 340, 403, 10.1007/BF00167041 · DOI · Paper page
  29. Frazer, 1990, 5-HT1A receptors and 5-HT1A-mediated responses: effect of treatments that modify serotonergic neurotransmission, Ann. NY Acad. Sci., 600, 460, 10.1111/j.1749-6632.1990.tb16902.x · DOI
  30. Fuster, 1985, The prefrontal cortex and temporal integration, 151, 10.1007/978-1-4757-9619-3_4 · DOI
  31. Gozlan, 1983, Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT, Nature, 305, 140, 10.1038/305140a0 · DOI · Paper page
  32. Gross-Isseroff, 1989, Autoradiographic analysis of tritated imipramine binding in the human brain post mortem: effects of suicide, Arch. Gen. Psychiatry, 46, 237, 10.1001/archpsyc.1989.01810030043006 · DOI
  33. Habert, 1985, Characterization of 3H-paroxetine binding to rat cortical membranes, Eur. J. Pharmacol., 118, 107, 10.1016/0014-2999(85)90668-5 · DOI · Paper page
  34. Hensler, 1994, Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus, Synapse, 17, 1, 10.1002/syn.890170102 · DOI
  35. Henteleff, 1991, Binding to serotonin uptake sites in prefrontal and temporal cortex of suicide victims, Soc. Neurosci. Abstr., 17, 1472
  36. Hrdina, 1984, Differentiation of two components of specific [3]imipramine binding in rat brain, Eur. J. Pharmacol., 102, 481, 10.1016/0014-2999(84)90569-7 · DOI
  37. Joyce, 1993, Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics, Neuropsychopharmacology, 8, 315, 10.1038/npp.1993.32 · DOI · Paper page
  38. Juorio, 1990, The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain, Gen. Pharmacol., 21, 759, 10.1016/0306-3623(90)91030-U · DOI
  39. Kilpatrick, 1988, The distribution of specific binding of the 5-HT3 receptor ligand [3H]GR65630 in rat brain using quantitative autoradiography, Neurosci. Lett., 94, 156, 10.1016/0304-3940(88)90287-X · DOI
  40. Korpi, 1986, Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. Comparison in chronic schizophrenic patients with suicide as cause of death, Arch. Gen. Psychiatry, 43, 594, 10.1001/archpsyc.1986.01800060088011 · DOI
  41. Kovachich, 1988, Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimpramine, Brain Res., 454, 78, 10.1016/0006-8993(88)90805-0 · DOI
  42. Lagattuta, 1992, Reduction in cortical serotonin transporter site number in suicide victims in the absence of altered levels of serotonin, its precursors or metabolite, Soc. Neurosci. Abstr., 18, 1598
  43. Laruelle, 1993, Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: a postmortem study, Arch. Gen. Psychiatry, 50, 810, 10.1001/archpsyc.1993.01820220066007 · DOI · Paper page
  44. Lawrence, 1990, Symmetrical hemispheric distribution of 3H-paroxetine binding sites in postmortem human brain from controls and suicides, Biol. Psychiatry, 28, 544, 10.1016/0006-3223(90)90492-K · DOI
  45. Lawrence, 1990, Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides, Brain Res., 526, 17, 10.1016/0006-8993(90)90244-6 · DOI
  46. Lloyd, 1974, Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients, Adv. Biochem. Psychopharmacol., 11, 387
  47. Lowry, 1951, Protein measurement with the folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI · Paper page
  48. Mann, 1989, Evidence for the 5-HT hypothesis of suicide: a review of post-mortem studies, Br. J. Psychiatry, 155, 7, 10.1192/S000712500029171X · DOI · Paper page
  49. Mann, 1992, Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients, Arch. Gen. Psychiatry, 49, 442, 10.1001/archpsyc.1992.01820060022003 · DOI · Paper page
  50. Mann, J.J., McBride, P.A., Malone, K.M., DeMeo, M.D. and Keilp, J., Blunted serotonergic responsivity in depressed patients, Neuropsychopharmacology, in press.
  51. Mann, 1986, Increased serotonin2 and β-adrenergic receptor binding in the frontal cortices of suicide victims, Arch. Gen. Psychiatry, 43, 954, 10.1001/archpsyc.1986.01800100048007 · DOI · Paper page
  52. Mann, J.J., Underwood, M.D. and Arango, V., Postmortem studies of suicide victims. In S.J. Watson (Ed.) Biology of Schizophrenia and Affective Disorders, Raven Press, New York, in press.
  53. Matsubara, 1991, Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims, J. Neural Transm., 85, 181, 10.1007/BF01244944 · DOI
  54. Meyerson, 1982, Human brain receptor alterations in suicide victims, Pharmacol. Biochem. Behav., 17, 159, 10.1016/0091-3057(82)90279-9 · DOI · Paper page
  55. Owen, 1986, Serotonergic mechanisms in brains of suicide victims, Brain Res., 362, 185, 10.1016/0006-8993(86)91415-0 · DOI · Paper page
  56. Owen, 1983, Brain 5-HT2 receptors and suicide, Lancet, ii, 1256, 10.1016/S0140-6736(83)91310-7 · DOI
  57. Pare, 1969, 5-Hydroxytryptamine, noradrenaline, and dopamine in brainstem, hypothalamus, and caudate nucleus of controls and of patients committing suicide by coal-gas poisoining, Lancet, ii, 133, 10.1016/S0140-6736(69)92442-8 · DOI · Paper page
  58. Patel, T.D., Azmitia, E.C. and Zhou, F.C., Increased 5-HT1A receptor immunoreactivity in the rat hippocampus following 5,7-DHT lesions in the cingulum bundle and fimbria-fornix, Behav. Brain Res., in press.
  59. Pazos, 1987, Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors, Neurosciece, 21, 97, 10.1016/0306-4522(87)90326-5 · DOI · Paper page
  60. Pedigo, 1981, Discrimination of multiple [3H]5-hydroxytryptamine binding sites by the neuroleptic spiperone in rat brain, J. Neurochem., 36, 220, 10.1111/j.1471-4159.1981.tb02397.x · DOI · Paper page
  61. Peroutka, 1979, Multiple serotonin receptors: differential binding to 3H-5-hydroxytryptamine, 3H-lysergic acid diethylamide and 3H-spiroperidol, Mol. Pharmacol., 16, 687, 10.1016/S0026-895X(25)13812-1 · DOI · Paper page
  62. Robinson, 1984, Mood disorders in stroke patients. Importance of location of lesion, Brain, 107, 81, 10.1093/brain/107.1.81 · DOI · Paper page
  63. Sackeim, 1982, Hemispheric asymmetry in the expression of positive and negative emotions, Arch. Neurol., 39, 210, 10.1001/archneur.1982.00510160016003 · DOI · Paper page
  64. Shaw, 1967, 5-Hydroxytryptamine in the hind-brain of depressive suicides, Br. J. Psychiatry, 113, 1407, 10.1192/bjp.113.505.1407 · DOI · Paper page
  65. Smith, 1992, 3H-cyanoimipramine binding is reduced in suicide victims, Soc. Neurosci. Abstr., 18, 1599
  66. Stanley, 1983, Alterations in pre- and postsynaptic serotonergic neurons in suicide victims, Psychopharmacol. Bull., 19, 684
  67. Stanley, 1982, Triated imipramine binding sites are decreased in the frontal cortex of suicides, Science, 216, 1337, 10.1126/science.7079769 · DOI · Paper page
  68. Starkstein, 1988, Depressive disorders following posterior circulation as compared with middle cerebral artery infarcts, Brain, 111, 375, 10.1093/brain/111.2.375 · DOI
  69. Stockmeier, 1986, In vivo regulation of serotonin-2 receptor in rat brain, Life Sci., 38, 117, 10.1016/0024-3205(86)90003-2 · DOI
  70. Taylor, 1990, Serotonin agents in anxiety, Ann. NY Acad. Sci., 600, 545, 10.1111/j.1749-6632.1990.tb16909.x · DOI
  71. Tecott, 1993, A new wave of serotonin receptors, Curr. Opin. Neurobiol., 3, 310, 10.1016/0959-4388(93)90122-F · DOI
  72. Träskman, 1981, Monoamine metabolites in CSF and suicidal behavior, Arch. Gen. Psychiatry, 38, 631, 10.1001/archpsyc.1981.01780310031002 · DOI · Paper page
  73. Underwood, 1992, Effect of lesions of the dorsal raphe nucleus on serotonin transporter, 5-HT1A and 5-HT2 binding sites in rat, Soc. Neurosci. Abstr., 18, 928
  74. van Woerkom, 1977, Difference in neurotransmitter metabolism in frontomporal-lobe contusion and diffuse cerebral contusion, Lancet, i, 812, 10.1016/S0140-6736(77)93008-2 · DOI · Paper page
  75. Welker, 1990, Why does cerebral cortex fissure and fold? A review of determinants of gyri and sulci, 3, 10.1007/978-1-4615-3824-0_1 · DOI · Paper page

Cited by

See all 459

Metadata

Authors
Arango, V., Underwood, M. D., Gubbi, A. V., & Mann, J. J.
Venue
Brain Research
Publisher
Elsevier BV
Published
1995-08
Volume
688
Issue
1-2
Pages
121-133
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(95)00523-s
OpenAlex
W2075327466
Cited by
459
References
0
FWCI
14.11
Type
journal article
Language
en
Open access
hybrid
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. https://app.cochat.ai/papers/10.1016/0006-8993(95)00523-s
The paper
Arango, V., Underwood, M. D., Gubbi, A. V., & Mann, J. J. (1995). Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research. https://doi.org/10.1016/0006-8993(95)00523-s

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.